Pharmacological evidence for neurokinin receptors in murine neuroblastoma C1300 cells.

abstract：:Increasing evidence suggests a role for ghrelin in the control of articular inflammatory diseases like osteoarthritis (OA). In the present study we examined the ability of ghrelin to counteract LPS-induced necrosis and apoptosis of chondrocytes and the involvement of GH secretagogue receptor (GHS-R)1a in the protectiv...

journal_title：Peptides

authors： Ceriotti S,Consiglio AL,Casati L,Cremonesi F,Sibilia V,Ferrucci F

更新日期：2018-05-01 00:00:00

abstract：:We applied computational biology to identify the linear amino acid sequence recognized by a mouse monoclonal antibody raised against the full length HPV16 E7 oncoprotein. Computer-assisted search for the epitopic peptide used two parameters: the capability of E7 peptides to bind to MHC class II molecules, and the simi...

journal_title：Peptides

authors： Kanduc D,Lucchese A,Mittelman A

更新日期：2001-12-01 00:00:00

abstract：:Investigators studying the primary culprit responsible for Alzheimer disease have, for the past two decades, primarily focused on amyloid-beta (Abeta). Here, we put Abeta on trial and review evidence amassed by the prosecution that implicate Abeta and also consider arguments and evidence gathered by the defense team w...

journal_title：Peptides

authors： Rottkamp CA,Atwood CS,Joseph JA,Nunomura A,Perry G,Smith MA

更新日期：2002-07-01 00:00:00

abstract：:Opioid receptor binding properties of [3H]Tyr-D-Ala-Phe-Phe-NH2 (TAPP) were characterized in rat brain and Chinese hamster ovary (CHO) cells expressing the rat mu-receptor. In rat brain, [3H]TAPP labeled a single class of opioid sites with a dissociation constant (Kd) of 0.31 nM and maximal number of binding sites (Bm...

journal_title：Peptides

authors： Spetea M,Otvös F,Tóth G,Nguyen TM,Schiller PW,Vogel Z,Borsodi A

更新日期：1998-01-01 00:00:00

abstract：:In recent years our knowledge of the nervous control of the cerebral circulation has increased. The use of denervations and retrograde tracing in combination with immunohistochemical techniques has demonstrated that cerebral vessels are supplied with sympathetic, parasympathetic, and sensory nerve fibers and possibly ...

journal_title：Peptides

authors： Gulbenkian S,Uddman R,Edvinsson L

更新日期：2001-06-01 00:00:00

abstract：:Selective GLP-1 secretagogues represent a novel potential therapy for type 2 diabetes mellitus. This study examined the GLP-1 secretory activity of the ethnomedicinal plant, Fagonia cretica, which is postulated to possess anti-diabetic activity. After extraction and fractionation extracts and purified compounds were t...

journal_title：Peptides

authors： Jafri L,Saleem S,Calderwood D,Gillespie A,Mirza B,Green BD

更新日期：2016-04-01 00:00:00

abstract：:Orexin (ORX) plays a critical role in reward-seeking behavior for natural rewards and drugs of abuse. The mesolimbic dopamine (DA) pathway that projects into the nucleus accumbens (NAc) from the ventral tegmental area is deeply involved in the neural mechanisms underlying reward, drug abuse and motivation. A recent st...

journal_title：Peptides

authors： Mori K,Kim J,Sasaki K

更新日期：2011-02-01 00:00:00

abstract：:Neural membrane fractions, prepared from brain-subesophageal ganglion complexes of the adult lepidopteran Lymantria dispar, contain at least two peptidases capable of metabolizing locust adipokinetic hormone-I in vitro. The initial fragments, pGlu1-Leu2-Asn3 and Phe4-Thr5-Pro6-Asn7-Trp8-Gly9-Thr10, result from the act...

journal_title：Peptides

authors： Masler EP,Wagner RM,Kovaleva ES

更新日期：1996-01-01 00:00:00

abstract：:Central nervous systems of the pond snail Lymnaea stagnalis were incubated in vitro in different concentrations of ORG 2766 (10(-9)-2.5 x 10(-4) M) for 10 and 20 h. Quantitative ultrastructural study of cross sections of the cerebral commissure showed that the number of microtubules in large axons had increased after ...

journal_title：Peptides

authors： Müller LJ,Moorer-van Delft CM,Boer HH

更新日期：1992-07-01 00:00:00

abstract：:In sheep, arginine vasopressin (AVP) and corticotropin-releasing factor (CRF) stimulate adrenocorticotropic hormone (ACTH) secretion. Increased hypothalamic secretion of these peptides at the end of gestation initiates parturition in this species. We hypothesized that CRF and/or AVP content in the fetal hypothalamus i...

journal_title：Peptides

authors： Saoud CJ,Wood CE

更新日期：1996-01-01 00:00:00

abstract：:The effects of infusion of low concentrations of the synthetic opioid peptide D-Pro4-beta-casomorphin-5(deprolorphin) on electrical field responses in the in vitro hippocampal slice preparation of mice were investigated. Deprolorphin (0.01-10 microM) causes a large enhancement of the population spike (PS) and appearan...

journal_title：Peptides

authors： Reymann KG,Chepkova AN,Matthies H

更新日期：1983-05-01 00:00:00

abstract：:We administered prolactin-releasing peptide (PrRP) or anti-PrRP antiserum to goldfish in fresh water and analyzed their effects on prolactin and osmoregulatory mechanisms. The pituitary mRNA level of prolactin increased by PrRP but decreased by anti-PrRP. The rate of water inflow in the gills decreased by PrRP and inc...

journal_title：Peptides

authors： Fujimoto M,Sakamoto T,Kanetoh T,Osaka M,Moriyama S

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Visfatin is a novel adipokine and proinflammatory cytokine which is implicated in breast cancer progression. The exact proliferative and anti-apoptotic mechanisms of visfatin are still under debate. In this study, the effect of extracellular visfatin on proliferation and apoptosis of breast cancer cells were...

journal_title：Peptides

authors： Gholinejad Z,Kheiripour N,Nourbakhsh M,Ilbeigi D,Behroozfar K,Hesari Z,Golestani A,Shabani M,Einollahi N

更新日期：2017-06-01 00:00:00

abstract：:The effects of atrial natriuretic factor (ANF) on [3H]norepinephrine ([3H]NE) release evoked by a sodium-free medium (SFM) were studied. Experiments were performed in rat adrenal medulla slices incubated in vitro. Results showed that [3H]NE release evoked by the omission of Na+ was decreased by 10 nM ANF. In addition,...

journal_title：Peptides

authors： Vatta MS,Papouchado ML,Bianciotti LG,Fernandez BE

更新日期：1994-01-01 00:00:00

abstract：:The hypophysiotrophic hormone corticotropin releasing factor (CRF) stimulates the anterior pituitary corticotroph to export stress hormones such as adrenocorticotrophic hormone (ACTH). In rat anterior pituitary cells, CRF-induced elevation of cyclic AMP was profoundly potentiated (by an order of magnitude) by stimulat...

journal_title：Peptides

authors： Cronin MJ,Zysk JR,Baertschi AJ

更新日期：1986-09-01 00:00:00

abstract：:The teleost salmon calcitonin (sCT), but not mammalian CT, shows similar biologic actions in the skeletal muscle as amylin and calcitonin gene-related peptide (CGRP). The peptides have also been shown to reduce food intake in rams. Because sCT, but not amylin, binds irreversibly to amylin binding sites, the aim of the...

journal_title：Peptides

authors： Lutz TA,Tschudy S,Rushing PA,Scharrer E

更新日期：2000-02-01 00:00:00

abstract：:A 41 amino acid peptide, probably identical in structure to human corticotropin releasing factor, was isolated from 70 equine hypothalami by methanol extraction, immunoaffinity chromatography and single step of reverse phase HPLC. The amino acid sequence was determined by gas phase sequence analysis. Probable carboxyl...

journal_title：Peptides

authors： Livesey JH,Carne A,Irvine CH,Ellis J,Evans MJ,Smith R,Donald RA

更新日期：1991-11-01 00:00:00

abstract：:Beta-amyloid (Aβ) peptides are secreted from neurons, resulting in extracellular accumulation of Aβ and neurodegeneration of Alzheimer's disease. Because neuronal secretion is fundamental for the release of neurotransmitters, this study assessed the hypothesis that Aβ undergoes co-release with neurotransmitters. Model...

journal_title：Peptides

authors： Toneff T,Funkelstein L,Mosier C,Abagyan A,Ziegler M,Hook V

更新日期：2013-08-01 00:00:00

abstract：:CGRP has potent cardiovascular effects but its role in heart failure is unclear. Effects of CGRP on calcium concentrations in fresh adult rat cardiomyocytes, cultured adult cardiomyocytes and neonatal cardiomyocytes were determined by real time fluorescence spectrophotometry. Treatment of cultured adult cardiomyocytes...

journal_title：Peptides

authors： Schiess MC,Poindexter BJ,Brown BS,Bick RJ

更新日期：2005-03-01 00:00:00

abstract：:The effects of third ventricular (IVT) injection of 25 micrograms of bradykinin (BK) upon plasma levels of LH, FSH, TSH, GH and prolactin were investigated in conscious ovariectomized female rats bearing indwelling jugular cannulae. Some animals were pretreated with bradykinin potentiating factor (BPF). Intravenous ad...

journal_title：Peptides

authors： Steele MK,Negro-Vilar A,McCann SM

更新日期：1980-10-01 00:00:00

abstract：:BMAP-27, a member of cathelicidin family, plays an important role against microorganisms, including bacteria and fungi. BMAP-27 may exert antimicrobial effects through membrane integrity disruption, but the exact molecular mechanism remains unclear. To identify the structural features important for antimicrobial activ...

journal_title：Peptides

authors： Yang S,Lee CW,Kim HJ,Jung HH,Kim JI,Shin SY,Shin SH

更新日期：2019-08-01 00:00:00

abstract：:High levels of neuropeptide Y (NPY) are found in the hypothalamus, median eminence, pituitary portal blood, and the pituitary in a number of species. Neuropeptide Y may influence the synthesis and secretion of a variety of hormones by interacting with specific receptors in the hypothalamus and/or the pituitary. To fur...

journal_title：Peptides

authors： Gehlert DR,Gackenheimer SL,Millington WR,Manning AB,Chronwall BM

更新日期：1994-01-01 00:00:00

abstract：:Ceratotoxin A (CtxA), a 36-residue alpha-helical cationic peptide isolated from the medfly Ceratitis capitata, exhibits strong antibacterial activity. To determine its mode of action against bacteria, we investigated the behavior of ceratotoxin A by incorporating it into planar lipid bilayers. Macroscopic and single c...

journal_title：Peptides

authors： Saint N,Marri L,Marchini D,Molle G

更新日期：2003-11-01 00:00:00

abstract：:A linear peptide containing two reduced cysteine residues can be rapidly converted to its oxidized cyclic form containing an intramolecular disulfide bond by adding an excess of 2,2'-bispyridyl disulfide (2,2'-dipyridyl disulfide or 2,2'-dithiodipyridine) to conventional buffer solutions. The reactants and products ar...

journal_title：Peptides

authors： Maruyama K,Nagasawa H,Suzuki A

更新日期：1999-01-01 00:00:00

abstract：:Ureases (EC 3.5.1.5) are metalloenzymes that hydrolyze urea into ammonia and CO(2). These proteins have insecticidal and fungicidal effects not related to their enzymatic activity. The insecticidal activity of urease is mostly dependent on the release of internal peptides after hydrolysis by insect digestive cathepsin...

journal_title：Peptides

authors： Postal M,Martinelli AH,Becker-Ritt AB,Ligabue-Braun R,Demartini DR,Ribeiro SF,Pasquali G,Gomes VM,Carlini CR

更新日期：2012-11-01 00:00:00

abstract：:Neuropeptide S (NPS), the endogenous ligand of NPS receptor (NPSR), regulates many biological functions, including arousal, anxiety, locomotion and food intake. NPSR mRNA is expressed in several regions of central autonomic network through which the brain controls visceromotor and other responses essential for surviva...

journal_title：Peptides

authors： Han RW,Chang M,Peng YL,Qiao LY,Yin XQ,Li W,Wang R

更新日期：2009-07-01 00:00:00

abstract：:The Manduca allatotropin (Mas-AT) gene is expressed as at least three mRNA isoforms that differ from each other by alternative splicing. The location at which the alternative exons are included in the mature mRNAs occur within the open reading frame, so that three different propeptides are predicted as translation pro...

journal_title：Peptides

authors： Horodyski FM,Bhatt SR,Lee KY

更新日期：2001-02-01 00:00:00

abstract：:The 41-residue corticotropin releasing factor (CRF) was synthesized by the solid phase method. The synthetic CRF and arginine vasopressin (AVP) were examined for ACTH releasing activity and effects on the release of 5 other pituitary hormones in vivo and in vitro. Injection of the CRF into pharmacologically blocked ra...

journal_title：Peptides

authors： Turkelson CM,Arimura A,Culler MD,Fishback JB,Groot K,Kanda M,Luciano M,Thomas CR,Chang D,Chang JK,Shimizu M

更新日期：1981-01-01 00:00:00

abstract：:Adrenocorticotropic Hormone (ACTH), Melanocyte-Stimulating Hormone (MSH), and related peptides have been shown to have several neurogenic effects: alteration of cerebral protein synthesis, RNA synthesis, protein phosphorylation, and neurotransmitter turnover. Furthermore, there appears to be an ACTH containing circuit...

journal_title：Peptides

authors： Beckwith BE,Sandman CA

更新日期：1982-05-01 00:00:00

abstract：:Neurotensin (NT) produces behavioral and physiological effects, including analgesia and hypotheria, when administered into the CNS. Fischer and Lewis rats exhibit differential behavioral responses to central NT receptor activation. To further characterize these differences, we assessed central NT-induced analgesia and...

journal_title：Peptides

authors： Bauco P,Rompré PP

更新日期：2003-08-01 00:00:00