Abstract:
:The Manduca allatotropin (Mas-AT) gene is expressed as at least three mRNA isoforms that differ from each other by alternative splicing. The location at which the alternative exons are included in the mature mRNAs occur within the open reading frame, so that three different propeptides are predicted as translation products. In the pharate adult insect, the major mRNA isoform expressed in the brain and frontal ganglion differs from that expressed in the nerve cord. Examination of the deduced translations of the alternative exons reveals the presence of three additional Mas-AT-like sequences that are flanked by basic amino acid residues. Therefore, the Mas-AT-like sequences present within the gene may be derived from a duplication of an ancestral Mas-AT-like sequence followed by divergence.
journal_name
Peptidesjournal_title
Peptidesauthors
Horodyski FM,Bhatt SR,Lee KYdoi
10.1016/s0196-9781(00)00378-8subject
Has Abstractpub_date
2001-02-01 00:00:00pages
263-9issue
2eissn
0196-9781issn
1873-5169pii
S0196-9781(00)00378-8journal_volume
22pub_type
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