Abstract:
:In the conscious dog migrating and nonmigrating colonic motor complexes (CMC) were recorded by means of chronically implanted strain gauge force transducers. Intravenous injection of a synthetic enkephalin analogue immediately induced a premature CMC at all three recording sites of the colon. Naloxone inhibited the enkephalin- but not motilin-induced CMC. We therefore exclude that motilin acts by release of endogenous enkephalins. The two peptides stimulate CMC in the canine colon by different pathways. Naloxone alone had no effect on normal colonic motility, suggesting strongly that endogenous enkephalins do not modulate regular CMC in the dog.
journal_name
Peptidesjournal_title
Peptidesauthors
Bickel M,Belz Udoi
10.1016/0196-9781(88)90155-6subject
Has Abstractpub_date
1988-05-01 00:00:00pages
501-7issue
3eissn
0196-9781issn
1873-5169pii
0196-9781(88)90155-6journal_volume
9pub_type
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