Tachykinin- and leucokinin-related peptides in the nervous system of the blowfly: immunocytochemical and chromatographical diversity.

abstract：:High affinity 125I-angiotensin II (Ang II) binding sites were characterized in the canine pancreas. Total binding increased with protein concentration and equilibrium was reached within 60-90 min at 22 degrees C. Specific binding was saturable and averaged 70% of total. Scatchard analysis of binding yielded a KD of 0....

journal_title：Peptides

authors： Chappell MC,Diz DI,Jacobsen DW

更新日期：1992-03-01 00:00:00

abstract：:Tissue inhibitor of metalloproteinases-2 (TIMP-2) inhibits angiogenesis by several mechanisms involving either MMP inhibition or direct endothelial cell binding. The primary aim of this study was to identify the TIMP-2 region involved in binding to the previously identified receptor integrin α3β1, and to determine whe...

journal_title：Peptides

authors： Seo DW,Saxinger WC,Guedez L,Cantelmo AR,Albini A,Stetler-Stevenson WG

更新日期：2011-09-01 00:00:00

abstract：:The elevated T-maze was combined with a free exploration protocol, which, in contrast to the conventional procedure, dispenses with handling of the animals during the experimental sessions. This allows measurement of fear indexes derived from the elevated plus-maze as well as assessment of acquisition of open arm avoi...

journal_title：Peptides

authors： Echeverry MB,Hasenöhrl RU,Huston JP,Tomaz C

更新日期：2001-07-01 00:00:00

abstract：:The synthesis, purification, and characterization of biotinylated analogues of motilin are reported. The C-terminal of canine motilin was extended by the addition of a cysteine residue, and then biotinylated. Biotinyl motilin was purified by following HPLC and characterized by amino acid analysis. Biotinylation of the...

journal_title：Peptides

authors： Sakai T,Satoh M,Hayashi H,Fujikura K,Sano I,Koyama H,Tatemoto K,Itoh Z

更新日期：1994-01-01 00:00:00

abstract：:Numerous substance P (SP) immunoreactive nerve fibers were located around submucosal glands in the guinea pig nasal mucosa. Since these SP positive nerve fibers were also positive for vasoactive intestinal polypeptide, and to a lessor extent for neuropeptide Y, they were presumed to be parasympathetic fibers. SP recep...

journal_title：Peptides

authors： Shibano A,Kawai Y,Senba E

更新日期：1998-01-01 00:00:00

abstract：:Several studies have documented cardiovascular effects of apelin, including enhanced inotropy and vasodilation. However, these cardiovascular effects are short lived due to the predicted short circulating half-life of the apelin peptide. To address this limitation of apelin, we pursued N-terminal PEGylation of apelin ...

journal_title：Peptides

authors： Jia ZQ,Hou L,Leger A,Wu I,Kudej AB,Stefano J,Jiang C,Pan CQ,Akita GY

更新日期：2012-11-01 00:00:00

abstract：:The reperfusion injury salvage kinase (RISK) pathway is a fundamental signal transduction cascade in the cardioprotective mechanism of ischemic postconditioning. In the present study, we examined the cardioprotective role of oxytocin as a postconditioning agent via activation of the RISK pathway (PI3K/Akt and ERK1/2)....

journal_title：Peptides

authors： Polshekan M,Jamialahmadi K,Khori V,Alizadeh AM,Saeidi M,Ghayour-Mobarhan M,Jand Y,Ghahremani MH,Yazdani Y

更新日期：2016-12-01 00:00:00

abstract：:A novel 6.6 kDa antifungal peptide (NFAP) from the culture supernatant of the mold, Neosartorya fischeri (anamorf: Aspergillus fischerianus), and its encoding gene were isolated in this study. NFAP is a small, basic and cysteine-rich protein consisting of 57 amino acid residues. It shows 37.9-50% homology to similar p...

journal_title：Peptides

authors： Kovács L,Virágh M,Takó M,Papp T,Vágvölgyi C,Galgóczy L

更新日期：2011-08-01 00:00:00

abstract：:Antisauvagine-30 (aSVG) is the only high-affinity antagonist for the corticotropin-releasing factor (CRF) type 2 (CRF(2)) receptor. A structure-activity relationship study was performed to pinpoint residues conferring aSVG's selectivity. The aSVG-analogues being N-terminally extended by one or two residues or containi...

journal_title：Peptides

authors： Brauns O,Brauns S,Jenke M,Zimmermann B,Dautzenberg FM

更新日期：2002-10-01 00:00:00

abstract：:Angiotensin(1-7) had a compound effect on blood pressure of pithed Sprague-Dawley rats. The initial phase of the response consisted of an increase in MAP of short duration and independent of injected dose, followed by a decline of arterial pressure to values below baseline. Both the magnitude (range: -4 +/- 1 to -13 +...

journal_title：Peptides

authors： Benter IF,Diz DI,Ferrario CM

更新日期：1993-07-01 00:00:00

abstract：:Spasmolytic polypeptide (SP) and intestinal trefoil factor (ITF) are trefoil peptides expressed by gut mucus cells. Using specific antisera we have quantified and characterized the molecular forms and distribution of these peptides in the rat gut. SP predominates in the gastric antrum as a 12 kDa form. ITF (7 kDa) is ...

journal_title：Peptides

authors： Taupin DR,Pang KC,Green SP,Giraud AS

更新日期：1995-01-01 00:00:00

abstract：:Atriopeptins are circulating peptide hormones which are secreted by atrial tissue and act at the kidney. Because the atriopeptins survive passage through the pulmonary circulation, they also may be involved in the modulation of airway or pulmonary vascular smooth muscle tone. Using in vitro organ bath techniques, atri...

journal_title：Peptides

authors： O'Donnell M,Garippa R,Welton AF

更新日期：1985-07-01 00:00:00

abstract：:Antimicrobial peptides, molecules produced in many different organisms, have high biocidal activity against several microorganisms. However, several questions about these molecules remain unclear. Therefore, this report details a systematic survey of the literature on the use of antimicrobial peptides against oral pat...

journal_title：Peptides

authors： da Silva BR,de Freitas VA,Nascimento-Neto LG,Carneiro VA,Arruda FV,de Aguiar AS,Cavada BS,Teixeira EH

更新日期：2012-08-01 00:00:00

abstract：:Increasing evidence suggests a role for ghrelin in the control of articular inflammatory diseases like osteoarthritis (OA). In the present study we examined the ability of ghrelin to counteract LPS-induced necrosis and apoptosis of chondrocytes and the involvement of GH secretagogue receptor (GHS-R)1a in the protectiv...

journal_title：Peptides

authors： Ceriotti S,Consiglio AL,Casati L,Cremonesi F,Sibilia V,Ferrucci F

更新日期：2018-05-01 00:00:00

abstract：:A newly developed system of isolated rat colonic epithelial cells was utilized for a comprehensive study of protein synthesis influenced by gastrin. We found that synthetic human gastrin (0.01-100 nM) increased the incorporation of [35S]methionine into proteins within 2 hours. Peak incorporation was observed with 10 n...

journal_title：Peptides

authors： Yassin RR,Clearfield HR,Katz SM,Murthy SN

更新日期：1991-01-01 00:00:00

abstract：:The heptadecapeptide, orphanin FQ or nociceptin (Phe-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln), originally isolated from rat brain has been identified as an endogenous ligand for the orphan opioid-like receptor. Although orphanin FQ shares some sequence and structural homology with kappa-opioid pept...

journal_title：Peptides

authors： Kavaliers M,Choleris E,Saucier DM

更新日期：1997-01-01 00:00:00

abstract：:The emergence of new and resistant viruses is a serious global burden. Conventional antiviral therapy with small molecules has led to the development of resistant mutants. In the case of hand, foot and mouth disease (HFMD), the absence of a US-FDA approved vaccine calls for urgent need to develop an antiviral that cou...

journal_title：Peptides

authors： Lalani S,Gew LT,Poh CL

更新日期：2020-11-07 00:00:00

abstract：:To further characterize the structure and function of calcitonin gene-related peptide (CGRP) related peptides in fish, we have cloned cDNA sequences for CGRP, amylin, adrenomedullin (AM) and adrenomedullin-2/intermedin (IMD) in goldfish (Carassius auratus) and examined their tissue distribution. CGRP, amylin, AM and I...

journal_title：Peptides

authors： Martínez-Alvarez RM,Volkoff H,Cueto JA,Delgado MJ

更新日期：2008-09-01 00:00:00

abstract：:A novel conotoxin, pc16a, was isolated from the venom of Conus pictus. This is the first peptide characterized from this South-African cone snail and it has only 11 amino acid residues, SCSCKRNFLCC*, with the rare cysteine framework XVI and a monoisotopic mass of 1257.6Da. Two peptides were synthesized with two possib...

journal_title：Peptides

authors： Van Der Haegen A,Peigneur S,Dyubankova N,Möller C,Marí F,Diego-García E,Naudé R,Lescrinier E,Herdewijn P,Tytgat J

更新日期：2012-03-01 00:00:00

abstract：:The present study demonstrates the occurrence of substance P (SP)- and calcitonin gene related peptide (CGRP)-immunoreactive nerve fibres in bone, bone marrow, periosteum, synovial membrane and soft tissues adjacent to the bone. The distribution pattern of the two types of nerves was similar, although the CGRP-positiv...

journal_title：Peptides

authors： Bjurholm A,Kreicbergs A,Brodin E,Schultzberg M

更新日期：1988-01-01 00:00:00

abstract：:Ghrelin is a 28 amino acid peptide, primarily produced by the oxyntic mucosa X/A like neuroendocrine cells in the stomach. It is also found in the small intestine, hypothalamus, pituitary gland, pancreas, heart, adipose tissue, and immune system. In gastrointestinal neuroendocrine tumors (NETs) ghrelin release has bee...

journal_title：Peptides

authors： Vu JP,Wang HS,Germano PM,Pisegna JR

更新日期：2011-11-01 00:00:00

abstract：:TRH and PS-24 (a TRH peptidase resistant analogue) induce different effects on body temperature and motor activity in rats kept at 4 degrees C. PS-24 induced hypothermia, but TRH did not. PS-24 induced hypermotility, while TRH induced slight hypomotility. The thermal effect of TRH in hypophysectomized rats was similar...

journal_title：Peptides

authors： Yehuda S,Youdim MB

更新日期：1981-07-01 00:00:00

abstract：:The relationship between gallbladder (GB) bile concentration and motility was studied in conscious dogs. The 12-h GB bile concentrations between meals could be divided into three periods: diluting, minimum, and concentrating periods. During the diluting period, inhibition of GB contractions by a CCKA receptor antagoni...

journal_title：Peptides

authors： Muramatsu S,Sonobe K,Mizumoto A,Yamada T,Itoh Z

更新日期：1997-01-01 00:00:00

abstract：:The effect and mode of action of pituitary adenylate cyclase activating polypeptide (PACAP) were studied in rat ileal strips. PACAP relaxed, concentration dependently, rat ileum and was 50 times more potent than the structurally related vasoactive intestinal polypeptide (VIP). The inhibitory action of PACAP was not mo...

journal_title：Peptides

authors： Katsoulis S,Clemens A,Schwörer H,Creutzfeldt W,Schmidt WE

更新日期：1993-05-01 00:00:00

abstract：:Vasopressin is one of the key regulators of the body's water and solute balance. When this balance is pathologically disturbed, determination of serum vasopressin concentrations might be a helpful tool for guiding therapy. However, due to its instability and considerable association to platelets, reliable measurement ...

journal_title：Peptides

authors： Struck J,Morgenthaler NG,Bergmann A

更新日期：2005-12-01 00:00:00

abstract：:Adrenocorticotropic Hormone (ACTH), Melanocyte-Stimulating Hormone (MSH), and related peptides have been shown to have several neurogenic effects: alteration of cerebral protein synthesis, RNA synthesis, protein phosphorylation, and neurotransmitter turnover. Furthermore, there appears to be an ACTH containing circuit...

journal_title：Peptides

authors： Beckwith BE,Sandman CA

更新日期：1982-05-01 00:00:00

abstract：:The neuropeptide Y system is known to have expanded in early vertebrate evolution. Three neuropeptide Y receptors have been proposed to have existed before the two basal vertebrate tetraploidizations, namely a Y1-like, a Y2-like, and a Y5-like receptor, with their genes in the same chromosomal region. Previously we ha...

journal_title：Peptides

authors： Xu B,Sundström G,Kuraku S,Lundell I,Larhammar D

更新日期：2013-01-01 00:00:00

abstract：:Two novel peptides, neuromedin U-8 and U-25, eliciting a potent uterus stimulating activity, have been purified and identified in porcine spinal cord. Sequence analyses and syntheses revealed that neuromedin U-8 is a novel octapeptide with a C-terminal amide structure, while U-25 contains the U-8 sequence at its C-ter...

journal_title：Peptides

authors： Minamino N,Sudoh T,Kangawa K,Matsuo H

更新日期：1985-01-01 00:00:00

abstract：:Many neuroendocrine peptides that are distributed in amphibian gastrointestinal tract and central nervous system are also found in amphibian skins, and these peptides are classified into skin-gut-brain triangle peptides, such as bombesins, gastrin-releasing peptides. Cholecystokinins (CCKs) are neuroendocrine peptides...

journal_title：Peptides

authors： Liu X,Wang Y,Cheng L,Song Y,Lai R

更新日期：2007-08-01 00:00:00

abstract：:Obestatin is a recently discovered peptide hormone that appears to be involved in reducing food intake, gut motility and body weight. Obestatin is a product of the preproghrelin gene and appears to oppose several physiological actions of ghrelin. This study investigated the acute effects of obestatin (1-23) and the tr...

journal_title：Peptides

authors： Green BD,Irwin N,Flatt PR

更新日期：2007-05-01 00:00:00