Abstract:
:A short neuropeptide F (sNPF) precursor and a sNPF receptor (sNPFR) were characterized for the mosquito, Anopheles gambiae. The sNPFR was expressed in CHO-K1 cells, and it exhibited high affinity binding, IC(50) approximately 3-5 nM, for specific sNPFs. sNPF1 potently inhibited forskolin-stimulated cAMP production by transfected cells, suggesting sNPFR acts via G(i/o). Transcripts for sNPF and sNPFR were present in all body regions of larvae, pupae, and adults, and immunoblots for sNPFR confirmed this distribution in females. Membranes from female heads and thoraces exhibited prototypical high affinity binding for radiolabeled sNPF, indicating sNPFR is a bona fide endogenous receptor.
journal_name
Peptidesjournal_title
Peptidesauthors
Garczynski SF,Crim JW,Brown MRdoi
10.1016/j.peptides.2006.09.019subject
Has Abstractpub_date
2007-01-01 00:00:00pages
109-18issue
1eissn
0196-9781issn
1873-5169pii
S0196-9781(06)00485-2journal_volume
28pub_type
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