Secretory pathways and processing of human proopiomelanocortin (POMC) using transformed mouse cultured fibroblasts (L cells) and AtT20 cells by human POMC gene--preembedding immunoelectron microscopic studies.

abstract：:We examined the mechanism through which leptin increases Na(+), K(+)-ATPase activity in the rat kidney. Leptin was infused under anaesthesia into the abdominal aorta proximally to the renal arteries and then Na(+), K(+)-ATPase activity was measured in the renal cortex and medulla. Leptin (1mug/kgmin) increased Na(+), ...

journal_title：Peptides

authors： Bełtowski J,Wójcicka G,Trzeciak J,Marciniak A

更新日期：2006-12-01 00:00:00

abstract：:The hypothalamic neuropeptide orexin A (hypocretin-1) is a key signal in sleep/wake regulation and promotes food intake. We investigated the relationship between cerebrospinal fluid orexin A concentrations and body composition in non-narcoleptic human subjects with a wide range of body weight to gain insight into the ...

journal_title：Peptides

authors： Santiago JCP,Otto M,Kern W,Baier PC,Hallschmid M

更新日期：2018-04-01 00:00:00

abstract：:The effects of amiloride on ANF binding and ANF stimulation of cGMP were evaluated in rat glomeruli. Amiloride increased ANF binding to whole glomeruli and to glomerular membrane preparations. In contrast, amiloride enhanced ANF-stimulated cGMP accumulation only at 37 degrees C in whole glomeruli, but not at 4 degrees...

journal_title：Peptides

authors： Iwata T,Hardee E,Frohlich ED,Cole FE

更新日期：1989-05-01 00:00:00

abstract：:The in vitro activity of six polycationic peptides, buforin II, cecropin P1, indolicidin, magainin II, nisin, and ranalexin, were evaluated against several clinical isolates of gram-positive and gram-negative aerobic bacteria, yeasts, Pneumocystis carinii and Cryptosporidium parvum, by using microbroth dilution method...

journal_title：Peptides

authors： Giacometti A,Cirioni O,Barchiesi F,Del Prete MS,Scalise G

更新日期：1999-11-01 00:00:00

abstract：:Prader-Willi syndrome is characterized by dramatic hyperphagia and morbid obesity, and is associated with a deficiency in basal and meal-stimulated serum pancreatic polypeptide (PP) levels. Intravenous infusions of pancreatic polypeptide (90 min, 50 pmol/kg/h) restored normal serum PP levels, and a regimen of morning ...

journal_title：Peptides

authors： Berntson GG,Zipf WB,O'Dorisio TM,Hoffman JA,Chance RE

更新日期：1993-05-01 00:00:00

abstract：:Cardiac preconditioning represents the most potent and consistently reproducible method of rescuing heart tissue from undergoing irreversible ischemic damage. One of the major goals of the current cardiovascular research is to identify a reliable cardioprotective intervention that can salvage ischemic myocardium. The ...

journal_title：Peptides

authors： Alizadeh AM,Faghihi M,Sadeghipour HR,Mohammadghasemi F,Imani A,Houshmand F,Khori V

更新日期：2010-07-01 00:00:00

abstract：:The distributions of neuropeptides in paraffin-embedded tissue sections (PETS) of the eyestalk, brain, and thoracic ganglia of the shrimp Penaeus monodon were visualized by imaging mass spectrometry (IMS). Peptide signals were obtained from PETS without affecting morphological features. Twenty-nine neuropeptides compr...

journal_title：Peptides

authors： Chansela P,Goto-Inoue N,Zaima N,Sroyraya M,Sobhon P,Setou M

更新日期：2012-03-01 00:00:00

abstract：:To confirm and extend the results of previous studies which demonstrated central cardiovascular effects of vasopressin in anesthetized rats, we determined blood pressure and heart rate changes for 30 minutes after intracerebroventricular injections of arginine vasopressin, arginine vasotocin and oxytocin in conscious ...

journal_title：Peptides

authors： Zerbe RL,Kirtland S,Faden AI,Feuerstein G

更新日期：1983-09-01 00:00:00

abstract：:Age-related changes in NPY-driven angiogenesis were investigated using Matrigel and aortic sprouting assays in young (2 months.) and aged (18 months.) mice. In both assays, NPY-induced vessel growth decreased significantly with age. In parallel, aged mice showed reduced expression (RT-PCR) of Y2 receptors and the NPY ...

journal_title：Peptides

authors： Kitlinska J,Lee EW,Movafagh S,Pons J,Zukowska Z

更新日期：2002-01-01 00:00:00

abstract：:Most small peptide hormones and neurotransmitters are highly flexible, conformationally labile molecules in aqueous and other environments. Thus efforts to determine the relationships between conformational properties of these peptides in aqueous and other solvents and their biological activities at membrane receptors...

journal_title：Peptides

authors： Hruby VJ,Mosberg HI

更新日期：1982-05-01 00:00:00

abstract：:Scorpion venoms are rich sources of biologically active peptides that are classified into disulfide-bridged peptides (DBPs) and non-disulfide-bridged peptides (NDBPs). DBPs are the main scorpion venom components responsible for the neurotoxic effects observed during scorpion envenomation as they usually target membran...

journal_title：Peptides

authors： Almaaytah A,Albalas Q

更新日期：2014-01-01 00:00:00

abstract：:There have been few reports on the effects of the brain-gut peptide motilin on the central nervous system (CNS). We administered motilin intracerebroventricularly to mice and investigated the effect of motilin on anxiety using an elevated plus-maze. Motilin produced a significant decrease in anxiety with an inverted U...

journal_title：Peptides

authors： Momose K,Inui A,Asakawa A,Ueno N,Nakajima M,Kasuga M

更新日期：1998-01-01 00:00:00

abstract：:Using a biologically active radioligand, [Tyr(125I)10]VIP, we have identified and characterized receptors for vasoactive intestinal peptide (VIP) on membranes prepared from the rat superior mesenteric artery and bovine coronary arteries. Binding was specific, saturable, reversible and dependent on time and temperature...

journal_title：Peptides

authors： Huang M,Rorstad OP

更新日期：1987-05-01 00:00:00

abstract：:CRF injected into the third cerebral ventricle (0.5-2.5 micrograms) caused dose-related reductions in fever induced in rabbits by IV administration of leukocytic pyrogen. Control injections of CRF when the same animals were afebrile did not alter normal body temperature. Intravenous injections of 5 and 20 micrograms C...

journal_title：Peptides

authors： Bernardini GL,Richards DB,Lipton JM

更新日期：1984-01-01 00:00:00

abstract：:We assessed the plasma acyl ghrelin (AG), unacyl ghrelin (UAG), and total ghrelin (TGhr) levels in Chinese adults with pre-diabetes and newly diagnosed diabetes mellitus (NDDM) after an oral glucose tolerance test (OGTT), and abdominal subcutaneous fat area and visceral fat area (VFA) were measured. Fasting AG level w...

journal_title：Peptides

authors： Huang L,Tong Y,Zhang F,Yang Q,Li D,Xie S,Li Y,Cao H,Tang L,Zhang X,Tong N

更新日期：2014-10-01 00:00:00

abstract：:Heparin-binding EGF-like growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, can protect intestinal epithelial cells from various forms of injury in vitro and attenuate intestinal ischemia/reperfusion damage in vivo. With the goal of eventual clinical use of HB-EGF to protect the intestines f...

journal_title：Peptides

authors： Feng J,Mehta VB,El-Assal ON,Wu D,Besner GE

更新日期：2006-06-01 00:00:00

abstract：:Endocrine regulation in vertebrates is critical for the adaptation and regulation of homeostasis. The G protein-coupled receptor (GPCR) signaling transduction system represents one of the most ancient forms of cell surface signaling. Recently, comparative sequence analysis has aided in the identification and pairing o...

journal_title：Peptides

authors： Chang CL,Roh J,Hsu SY

更新日期：2004-10-01 00:00:00

abstract：:A putative genome duplication event within the Silurana lineage has given rise to the tetraploid Cameroon clawed frog Silurana epitropicalis (Fischberg, Colombelli, and Picard, 1982). Peptidomic analysis of norepinephrine-stimulated skin secretions of S. epitropicalis led to identification of 10 peptides with varying ...

journal_title：Peptides

authors： Conlon JM,Mechkarska M,Prajeep M,Sonnevend A,Coquet L,Leprince J,Jouenne T,Vaudry H,King JD

更新日期：2012-09-01 00:00:00

abstract：:The emergence of new and resistant viruses is a serious global burden. Conventional antiviral therapy with small molecules has led to the development of resistant mutants. In the case of hand, foot and mouth disease (HFMD), the absence of a US-FDA approved vaccine calls for urgent need to develop an antiviral that cou...

journal_title：Peptides

authors： Lalani S,Gew LT,Poh CL

更新日期：2020-11-07 00:00:00

abstract：:Pea albumin 1F (PA1F), a plant peptide isolated from pea seeds, can dramatically increase blood glucose concentration by subcutaneous injection with a dosage of 5 or 10 microg/g (body weight) in normal and type II diabetic mice (KK/upj-Ay). The voltage-dependent anion channel 1 (VDAC-1) has been identified as the PA1F...

journal_title：Peptides

authors： Dun XP,Li FF,Wang JH,Chen ZW

更新日期：2008-06-01 00:00:00

abstract：:The hypophysiotrophic hormone corticotropin releasing factor (CRF) stimulates the anterior pituitary corticotroph to export stress hormones such as adrenocorticotrophic hormone (ACTH). In rat anterior pituitary cells, CRF-induced elevation of cyclic AMP was profoundly potentiated (by an order of magnitude) by stimulat...

journal_title：Peptides

authors： Cronin MJ,Zysk JR,Baertschi AJ

更新日期：1986-09-01 00:00:00

abstract：:Food deprivation inhibits estrous behavior in several species of rodents, but little is known about the neurotransmitter systems mediating this phenomenon. We determined whether partial blockade of opioid receptors by continuous infusion of naltrexone and/or acute peripheral injection of cholecystokinin (CCK) administ...

journal_title：Peptides

authors： Jones JE,Corp ES,Wade GN

更新日期：2001-04-01 00:00:00

abstract：:Several studies have documented cardiovascular effects of apelin, including enhanced inotropy and vasodilation. However, these cardiovascular effects are short lived due to the predicted short circulating half-life of the apelin peptide. To address this limitation of apelin, we pursued N-terminal PEGylation of apelin ...

journal_title：Peptides

authors： Jia ZQ,Hou L,Leger A,Wu I,Kudej AB,Stefano J,Jiang C,Pan CQ,Akita GY

更新日期：2012-11-01 00:00:00

abstract：:Cationic lytic-type peptides have been studied for clinical application in various infections and cancers. This study aimed to determine the functions of our specially designed lytic peptide. To investigate the functional mechanism at the cell membrane level, we used giant unilayer vesicles (GUVs) mimicking cell membr...

journal_title：Peptides

authors： Ohara K,Kohno M,Hamada T,Kawakami K

更新日期：2013-12-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) was recently found in the myocardium, but possible insights into differences between atrium and ventricle production are so far lacking. Our aim was to evaluate, in an experimental model of pacing-induced heart failure (HF), plasma and tissue levels of CNP and mRNA expression of the pe...

journal_title：Peptides

authors： Del Ry S,Cabiati M,Lionetti V,Emdin M,Recchia FA,Giannessi D

更新日期：2008-12-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) is a potent orexigenic and sleep-promoting neuropeptide in mammals produced predominately by hypothalamic neurons which project to a wide variety of brain areas. Several MCH producing neurons contain MCH as the only neuropeptide, while others comprise cocaine- and amphetamine regula...

journal_title：Peptides

authors： Jancsik V,Bene R,Sótonyi P,Zachar G

更新日期：2018-01-01 00:00:00

abstract：:We have previously developed an in vitro model of rat brainstem explants. The latter release sizable amounts of calcitonin gene-related peptide (CGRP); basal release can be stimulated by such secretagogues as high KCl concentrations, veratridine or capsaicine. In this paradigm we investigated the activity of the analg...

journal_title：Peptides

authors： Greco MC,Lisi L,Currò D,Navarra P,Tringali G

更新日期：2014-06-01 00:00:00

abstract：:The rat central and peripheral nervous system contains a widespread distribution of BPP-like immunoreactive neurons. Some of these neurons coexist with a catecholamine, probably mostly NE. This peptide appears to be releaseable by nerve stimulation. Catecholamine releasing agents such as reserpine do not appear to dep...

journal_title：Peptides

authors： Jacobowitz DM,Olschowka JA

更新日期：1982-05-01 00:00:00

abstract：:Food deprivation and adrenalectomy are associated with low concentrations of leptin in blood and the absence of obesity. Because leptin is known to cross the blood-brain barrier (BBB) by a saturable transport system, we examined whether fasting and adrenalectomy (ADX) also act at the BBB. Multiple-time regression anal...

journal_title：Peptides

authors： Kastin AJ,Akerstrom V

更新日期：2000-05-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) has attracted considerable attention because of its effects on food intake and body weight and the MCH receptor (MCHR1) remains one of the viable targets for obesity therapy. This review summarizes the literature examining the effects of MCH on body weight, food intake and energy ex...

journal_title：Peptides

authors： Pissios P

更新日期：2009-11-01 00:00:00