Antipyretic effect of centrally administered CRF.

abstract：:N-hydroxysuccinimide (NHS) esters of biotin are reported to react specifically with amino groups of peptides and proteins. However, we have found that these reagents can readily acylate other functional groups in specific peptide sequences under relatively mild conditions. We have extended our inquiry of sequence-depe...

journal_title：Peptides

authors： Miller BT,Collins TJ,Rogers ME,Kurosky A

更新日期：1997-01-01 00:00:00

abstract：:Motilin-immunopositive cells (Mo cells) are known to be present in the upper small intestine of various species, including man. However, whether Mo cells are present in the rabbit gastrointestinal tract remained to be elucidated. Therefore, this study was designed to investigate the distribution of Mo cells in the rab...

journal_title：Peptides

authors： Satoh M,Sakai T,Koyama H,Shiba Y,Itoh Z

更新日期：1995-01-01 00:00:00

abstract：:The discovery of several adipokines with diverse activities and their involvement in regulation of various pathophysiological functions of human body has challenged the researchers. In the family of adipokine, chemerin is a novel and unique addition. Ever since the first report on chemerin as a chemo-attractant protei...

journal_title：Peptides

authors： Fatima SS,Rehman R,Baig M,Khan TA

更新日期：2014-12-01 00:00:00

abstract：:Mastoparan (MP) peptides, distributed in insect venoms, induce a local inflammatory response post envenomation. Most endogenous MPs share common structural elements within a tetradecapeptide sequence that adopts an amphipathic helix whilst traversing biological membranes and when bound to an intracellular protein targ...

journal_title：Peptides

authors： Howl J,Howl L,Jones S

更新日期：2018-03-01 00:00:00

abstract：:CART (cocaine- and amphetamine-regulated transcript) peptides are neuropeptides abundant in the central nervous system and periphery found to be involved in the regulation of food intake behavior and other physiological processes. Recently, we reported specific binding of (125)I-CART(61-102) to the rat adrenal pheochr...

journal_title：Peptides

authors： Maixnerová J,Hlavácek J,Blokesová D,Kowalczyk W,Elbert T,Sanda M,Blechová M,Zelezná B,Slaninová J,Maletínská L

更新日期：2007-10-01 00:00:00

abstract：:Hymenochirin-1B (IKLSPETKDN(10)LKKVLKGAIK(20)GAIAVAKMV.NH2) is a cationic, amphipathic, α-helical, host-defense peptide, first isolated from skin secretions of the Congo clawed frog Hymenochirus boettgeri (Pipidae). Structure-activity relationships were investigated by synthesizing analogs in which the Pro(5), Glu(6) ...

journal_title：Peptides

authors： Mechkarska M,Prajeep M,Radosavljevic GD,Jovanovic IP,Al Baloushi A,Sonnevend A,Lukic ML,Conlon JM

更新日期：2013-12-01 00:00:00

abstract：:Of twelve dipeptides tested, only the Trp containing peptides Val-Trp and its reverse peptide Trp-Val showed a xanthine oxidase (XO) inhibitory activity. Studies with Val and Trp revealed that XO inhibition was mainly attributed to the Trp residue. No significant difference (P ≥ 0.05) was found for the XO inhibitory p...

journal_title：Peptides

authors： Nongonierma AB,Fitzgerald RJ

更新日期：2012-10-01 00:00:00

abstract：:We investigated the plasma concentration of ghrelin peptide during pregnancy and lactation in rats. Plasma ghrelin levels on days 10 and 15 of pregnancy were significantly lower than those of the non-pregnant rats. Thereafter, the plasma ghrelin levels on day 20 of pregnancy sharply increased to levels comparable with...

journal_title：Peptides

authors： Shibata K,Hosoda H,Kojima M,Kangawa K,Makino Y,Makino I,Kawarabayashi T,Futagami K,Gomita Y

更新日期：2004-02-01 00:00:00

abstract：:Parathyroid hormone (PTH) has been shown to have actions within the brain, suggesting the presence of central PTH receptors. This possibility was examined by determining the binding of 125I-labeled [Nle8,18,Tyr34]bovine PTH to the plasma membranes of rat and rabbit brains. Specific binding of the tracer to membranes o...

journal_title：Peptides

authors： Harvey S,Hayer S

更新日期：1993-11-01 00:00:00

abstract：:Recent refinements in methodology now permit the study of endogenous peptide hormones in their individual target cells. The investigations reported here deal with the question of whether endogenous ACTH can be detected in its target cells in the highly active adrenal gland of the normally lactating rat. This question ...

journal_title：Peptides

authors： Nolin JM

更新日期：1980-10-01 00:00:00

abstract：:The presence of the proenkephalin A-derived peptide Met5-enkephalin-Arg6-Gly7-Leu8 was demonstrated throughout the human gastrointestinal tract. Highest concentrations of Met5-enkephalin-Arg6-Gly7-Leu8, as assessed by radioimmunoassay, were measured in the separated muscularis externa, while lower levels were found in...

journal_title：Peptides

authors： Ferri GL,Morreale RA,Dockray GJ

更新日期：1986-09-01 00:00:00

abstract：:Corticotropin releasing hormone (CRH) stimulates pituitary ACTH secretion through type-1 CRH (CRH1) receptors. Stimulation of the hypothalamic pituitary adrenal (HPA) axis as well as increased corticotroph responsiveness during stress and adrenalectomy are associated with marked pituitary CRH binding downregulation. T...

journal_title：Peptides

authors： Aguilera G,Rabadan-Diehl C,Nikodemova M

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Since short bowel syndrome (SBS) patients face life-threatening conditions, the development of therapeutic strategies to induce intestinal adaptation has been investigated. Ghrelin, a ligand of growth hormone (GH) secretagogue-receptor that stimulates the release of GH and insulin like growth factor-1 (IGF-1...

journal_title：Peptides

authors： Onishi S,Kaji T,Yamada W,Nakame K,Machigashira S,Kawano M,Yano K,Harumatsu T,Yamada K,Masuya R,Kawano T,Mukai M,Hamada T,Souda M,Yoshioka T,Tanimoto A,Ieiri S

更新日期：2018-08-01 00:00:00

abstract：:The effect of intraplantarly (i.pl.)-injected methionine-enkephalin (ME) on Concanavalin A (Con A)-induced paw edema in Dark Agouti (DA) and Albino Oxford (AO) rats was investigated. ME suppressed edema in DA rats, which was antagonized with naloxone (non-selective opioid receptor antagonist) and naltrindole (delta op...

journal_title：Peptides

authors： Stanojević S,Radulović J,Kovacević-Jovanović V,Vujić V,Dimitrijević M

更新日期：2002-09-01 00:00:00

abstract：:Interdigestive migrating contractions (IMC) were analyzed for their occurrence interval, duration, migrating velocity, and frequently in long term records obtained by means of chronically implanted force transducers in the main stomach and the extrinsically denervated fundic pouches or in the intact jejunum and the ex...

journal_title：Peptides

authors： Itoh Z,Nakaya M,Suzuki T

更新日期：1981-01-01 00:00:00

abstract：:We studied the effects of calcitonin gene-related peptide (CGRP) on ciliary beat frequency (CBF) and electrical properties of canine tracheal epithelium by a photoelectric method and Ussing's short-circuit technique, respectively. CGRP dose dependently increased CBF, an effect that was accompanied by elevation of intr...

journal_title：Peptides

authors： Tamaoki J,Kanemura T,Kobayashi K,Sakai N,Takizawa T

更新日期：1989-09-01 00:00:00

abstract：:This work determined Plasmodium falciparum merozoite surface protein-8 (MSP-8) regions specifically binding to membrane surface receptors on human erythrocytes. Five high activity binding peptides (HABPs), whose binding to erythrocytes became saturable and sensitive on being treated with neuraminidase and chymotrypsin...

journal_title：Peptides

authors： Puentes A,García J,Ocampo M,Rodríguez L,Vera R,Curtidor H,López R,Suarez J,Valbuena J,Vanegas M,Guzman F,Tovar D,Patarroyo ME

更新日期：2003-07-01 00:00:00

abstract：:The neuropeptide Y system is known to have expanded in early vertebrate evolution. Three neuropeptide Y receptors have been proposed to have existed before the two basal vertebrate tetraploidizations, namely a Y1-like, a Y2-like, and a Y5-like receptor, with their genes in the same chromosomal region. Previously we ha...

journal_title：Peptides

authors： Xu B,Sundström G,Kuraku S,Lundell I,Larhammar D

更新日期：2013-01-01 00:00:00

abstract：:A non-specific lipid transfer peptide (nsLTP) with antimicrobial activity was isolated from the mung bean (Phaseolus mungo) seeds. The procedure entailed aqueous extraction, ion exchange chromatography on CM-Sephadex and high performance liquid chromatography (HPLC) on POROS-HS-20. The peptide exhibited a molecular ma...

journal_title：Peptides

authors： Wang SY,Wu JH,Ng TB,Ye XY,Rao PF

更新日期：2004-08-01 00:00:00

abstract：:Structurally unique, synthetic prion peptides provide the basis of a simple assay to serve as both a detection and signal amplification system that distinguishes the normal prion protein, PrPC, from the misfolded prion protein, PrPSc, that is associated with the occurrence of transmissible spongiform encephalopathies ...

journal_title：Peptides

authors： Grosset A,Moskowitz K,Nelsen C,Pan T,Davidson E,Orser CS

更新日期：2005-11-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) is a hypothalamic peptide that plays a critical role in the regulation of food intake and energy metabolism. In this study, we investigated the potential role of dense hippocampal MCH innervation in the spatially oriented food-seeking component of feeding behavior. Rats were trained...

journal_title：Peptides

authors： Sita LV,Diniz GB,Canteras NS,Xavier GF,Bittencourt JC

更新日期：2016-02-01 00:00:00

abstract：:Intrathecal injection of mice with substance P (SP) or its C-terminal fragments results in a behavioral syndrome characterized by reciprocal caudally directed biting and scratching. Repeated injection of SP, but not SP C-terminal fragments, results in a decrease in the intensity of, or desensitization to, these SP-ind...

journal_title：Peptides

authors： Igwe OJ,Sun X,Larson AA

更新日期：1990-07-01 00:00:00

abstract：:Vascular permeability and endothelial cell damage has been shown to occur in rats subjected to trauma with hemorrhagic-shock. Although the factors responsible for the endothelial cell injury are unknown, it has been hypothesized that toxic factors produced in response to hemorrhagic-shock originate in the gut and are ...

journal_title：Peptides

authors： Kaiser VL,Sifri ZC,Senthil M,Dikdan GS,Lu Q,Xu DZ,Deitch EA

更新日期：2005-12-01 00:00:00

abstract：:The effects of amiloride on ANF binding and ANF stimulation of cGMP were evaluated in rat glomeruli. Amiloride increased ANF binding to whole glomeruli and to glomerular membrane preparations. In contrast, amiloride enhanced ANF-stimulated cGMP accumulation only at 37 degrees C in whole glomeruli, but not at 4 degrees...

journal_title：Peptides

authors： Iwata T,Hardee E,Frohlich ED,Cole FE

更新日期：1989-05-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) is a potent anti-inflammatory agent. In addition to the deactivation of macrophages, dendritic cells, and microglia, VIP shifts the Th1/Th2 balance, promoting the preferential differentiation and survival of Th2 cells, to the detriment of the proinflammatory Th1 effectors. Several m...

journal_title：Peptides

authors： Liu L,Yen JH,Ganea D

更新日期：2007-09-01 00:00:00

abstract：:Heparin-binding EGF-like growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, can protect intestinal epithelial cells from various forms of injury in vitro and attenuate intestinal ischemia/reperfusion damage in vivo. With the goal of eventual clinical use of HB-EGF to protect the intestines f...

journal_title：Peptides

authors： Feng J,Mehta VB,El-Assal ON,Wu D,Besner GE

更新日期：2006-06-01 00:00:00

abstract：:Several studies have documented cardiovascular effects of apelin, including enhanced inotropy and vasodilation. However, these cardiovascular effects are short lived due to the predicted short circulating half-life of the apelin peptide. To address this limitation of apelin, we pursued N-terminal PEGylation of apelin ...

journal_title：Peptides

authors： Jia ZQ,Hou L,Leger A,Wu I,Kudej AB,Stefano J,Jiang C,Pan CQ,Akita GY

更新日期：2012-11-01 00:00:00

abstract：:Dissociated neurointermediate lobe cells (75%) bound [biotinyl-Ser1]corticotropin releasing hormone (bio-CRH) and secreted adrenocorticotropin [ACTH(25-39)] in a reverse hemolytic plaque assay (RHPA). The bio-CRH was rapidly internalized (less than 1 min) in vesicles and scattered vacuoles. Plaque percentages increase...

journal_title：Peptides

authors： Childs GV

更新日期：1990-07-01 00:00:00

abstract：:The melanocortin 4 receptor (MC4R) plays an essential role in weight regulation. Recently we could show that the MC4R is able to form receptor dimers. In the present study we investigated the role of extracellular cysteine residues and the structure of the third extracellular loop for receptor dimerization. None of th...

journal_title：Peptides

authors： Elsner A,Tarnow P,Schaefer M,Ambrugger P,Krude H,Grüters A,Biebermann H

更新日期：2006-02-01 00:00:00

abstract：:Using a biologically active radioligand, [Tyr(125I)10]VIP, we have identified and characterized receptors for vasoactive intestinal peptide (VIP) on membranes prepared from the rat superior mesenteric artery and bovine coronary arteries. Binding was specific, saturable, reversible and dependent on time and temperature...

journal_title：Peptides

authors： Huang M,Rorstad OP

更新日期：1987-05-01 00:00:00