Abstract:
:We studied the effects of calcitonin gene-related peptide (CGRP) on ciliary beat frequency (CBF) and electrical properties of canine tracheal epithelium by a photoelectric method and Ussing's short-circuit technique, respectively. CGRP dose dependently increased CBF, an effect that was accompanied by elevation of intracellular cyclic AMP but not affected by blockade of either Ca2+-influx or arachidonic acid metabolism. In contrast, CGRP elicited only a small and transient increase in short-circuit current without significant alterations in transepithelial potential difference or tissue conductance. These results suggest that CGRP may play a role in regulating airway mucociliary transport function.
journal_name
Peptidesjournal_title
Peptidesauthors
Tamaoki J,Kanemura T,Kobayashi K,Sakai N,Takizawa Tdoi
10.1016/0196-9781(89)90183-6subject
Has Abstractpub_date
1989-09-01 00:00:00pages
1007-11issue
5eissn
0196-9781issn
1873-5169pii
0196-9781(89)90183-6journal_volume
10pub_type
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