Abstract:
:The typical cardiovascular response to polymicrobial sepsis is characterized by an early, hyperdynamic phase followed by a late, hypodynamic phase. Although the factors and/or mediators responsible for producing the transition from the hyperdynamic to the hypodynamic stage are not fully understood, recent studies have suggested that adrenomedullin (AM), a potent vasodilatory peptide, appears to play an important role in initiating the hyperdynamic response following the onset of sepsis. In addition, the reduced vascular responsiveness to AM may result in the transition from the early, hyperdynamic phase to the late, hypodynamic phase of sepsis. It is possible that changes in newly reported AM receptors calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein-2 or -3 (RAMP2, RAMP3) as well as AM binding protein-1 (AMBP-1) may also play distinct roles in the biphasic cardiovascular response observed during sepsis. Although it remains unknown whether AM gene delivery or a chronic increase in vascular AM production in transgenic animals attenuates the development of hypodynamic sepsis and septic shock, it has been shown that modulation of AM vascular responsiveness with pharmacologic agents reduces sepsis-induced mortality. It has been recently demonstrated that AMBP-1 enhances AM's physiologic effects and plasma levels of AMBP-1 decrease following infections. We therefore propose that downregulation of AMBP-1 and the reduced AM receptor responsiveness are crucial factors responsible for the transition from the hyperdynamic phase to the hypodynamic phase of sepsis.
journal_name
Peptidesjournal_title
Peptidesauthors
Wang Pdoi
10.1016/s0196-9781(01)00534-4subject
Has Abstractpub_date
2001-11-01 00:00:00pages
1835-40issue
11eissn
0196-9781issn
1873-5169pii
S0196-9781(01)00534-4journal_volume
22pub_type
杂志文章,评审相关文献
PEPTIDES文献大全abstract::Sympathetic neurotransmitter neuropeptide Y (NPY) is associated with vascular remodelling, neointimal hyperplasia and atherosclerosis in experimental animal models and clinical studies. In order to study the role of sympathetic nerve-produced NPY in vascular diseases, transgenic mouse model overexpressing NPY in centr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.12.009
更新日期:2009-04-01 00:00:00
abstract::The presence of immunoreactive endothelin (IR-ET) in human saliva and rat parotid gland was investigated by radioimmunoassay. The IR-ET concentration (mean +/- SEM) in saliva taken from normal volunteers was 2.0 +/- 0.2 pmol/l (n = 15). The IR-ET concentration in rat parotid gland was 19.2 +/- 2.2 fmol/g wet weight (n...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90151-e
更新日期:1991-07-01 00:00:00
abstract::Both diapause hormone (DH) and ecdysone (E) are capable of terminating pupal diapause in members of the Helicoverpa/Heliothis complex. In this study we examine how the transcript encoding prothoracicotropic hormone (PTTH), the neuropeptide that stimulates the prothoracic gland to produce E, and the transcript encoding...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.05.019
更新日期:2012-03-01 00:00:00
abstract::This study determined the long-term influence of prenatal nicotine exposure (PN) on blood pressure and vascular functions in the aged offspring rats. PN did not affect body weight and plasma adrenocorticotropic hormone level; however, it significantly reduced plasma angiotensin I and angiotensin II in both sexes. Syst...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.02.019
更新日期:2013-06-01 00:00:00
abstract::The major amyloid-beta (Abeta) peptides found in the brain of familial and late onset Alzheimer's disease include the full-length Abeta1-42 and N-terminally truncated, pyroglutamylated peptides Abetap3-42 and Abetap11-42. The biophysical properties of Abeta1-42 have been extensively studied, yet little is known about ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.01.027
更新日期:2009-05-01 00:00:00
abstract::This paper reviews aspects of our research, focusing on the role of the melanocortin system in the central regulation of feeding and energy balance, which was begun in 1997. It describes data from successive physiological studies, concerning the identity of the appetite-regulating melanocortin receptor, melanocortin-4...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2005.01.030
更新日期:2006-02-01 00:00:00
abstract::Neuropeptide Y-containing nerve fibers have previously been demonstrated to innervate the mammalian ovary. These nerve fibers innervate primarily the vasculature. In this study we have developed a method for in vivo measurement of the ovary blood flow rate by means of the 133Xe method. Using this technique we measured...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90041-3
更新日期:1990-05-01 00:00:00
abstract::Neurotensin exerts its actions in the central nervous system and the periphery through three identified receptors. Two of them, the NTS2 and NTS3, display unusual properties either because of their complex signal transduction mechanisms (NTS2) or because of their structural composition as a non-G-protein-coupled recep...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2006.04.026
更新日期:2006-10-01 00:00:00
abstract::Peptic digestion of bovine hemoglobin at low degree of hydrolysis yields an intermediate peptide fraction exhibiting antibacterial activity against Micrococcus luteus A270, Listeria innocua, Escherichia coli and Salmonella enteritidis after separation by reversed-phase HPLC. From this fraction a pure peptide was isola...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.12.008
更新日期:2005-05-01 00:00:00
abstract::Recent studies have provided evidence for the dense localization of atrial natriuretic factor (ANF) in the anteroventral third ventricle (AV3V) region of the rat brain. This area is currently thought to be involved in the regulation of blood pressure and fluid and electrolyte balance. To investigate whether ANF may pl...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90425-5
更新日期:1985-11-01 00:00:00
abstract::We have developed a specific and sensitive radioimmunoassay for the hydra head activator neuropeptide (HHAP). The antibody recognizes the C-terminal portion of HHAP and shows no cross-reactivity with other neuropeptides. The assay allows measurement of HHAP-like material in tissue extracts with a minimum detectable co...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90081-f
更新日期:1990-03-01 00:00:00
abstract::C-type natriuretic peptide (CNP) is expressed in the vascular endothelium. It is not known whether CNP is specifically increased in patients with idiopathic left ventricular systolic dysfunction (ILVDys) with or without overt heart failure, and whether in these patients it is related with indicators of myocardial and/...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.03.002
更新日期:2007-05-01 00:00:00
abstract::Effects of spantide ([D-Arg1,D-Trp7,9,Leu11]substance P) on coronary resistance vessels were studied in isolated guinea pig hearts perfused at constant rate with isotonic buffer containing 20 or 40 mM KCl. Spantide (1 microM) caused a 20-fold rightward shift of the substance P (SP) dose-response curve for vasodilation...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90047-s
更新日期:1991-09-01 00:00:00
abstract::Angiotensin(1-7) had a compound effect on blood pressure of pithed Sprague-Dawley rats. The initial phase of the response consisted of an increase in MAP of short duration and independent of injected dose, followed by a decline of arterial pressure to values below baseline. Both the magnitude (range: -4 +/- 1 to -13 +...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90097-z
更新日期:1993-07-01 00:00:00
abstract::Intracerebroventricular administration of NPY suppresses ethanol intake in selectively bred alcohol-preferring rat lines, but not in rats selectively bred for low ethanol drinking or in unselected Wistar rats, when access to ethanol is limited to 2h/day. However, when rats undergo chronic (24h/day) ethanol drinking (o...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2006.07.028
更新日期:2007-02-01 00:00:00
abstract::The aim of this study was to investigate peripheral and central roles of corticotropin-releasing factor (CRF) in endocrinological and behavioral changes. Plasma adrenocorticotropin (ACTH) concentration was measured as an activity of hypothalamic-pituitary-adrenal (HPA) axis. As behavioral changes, locomotion and anxie...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.06.009
更新日期:2017-09-01 00:00:00
abstract::CART (cocaine- and amphetamine-regulated transcript) peptides are neuropeptides abundant in the central nervous system and periphery found to be involved in the regulation of food intake behavior and other physiological processes. Recently, we reported specific binding of (125)I-CART(61-102) to the rat adrenal pheochr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.07.022
更新日期:2007-10-01 00:00:00
abstract::Ceratotoxin A (CtxA), a 36-residue alpha-helical cationic peptide isolated from the medfly Ceratitis capitata, exhibits strong antibacterial activity. To determine its mode of action against bacteria, we investigated the behavior of ceratotoxin A by incorporating it into planar lipid bilayers. Macroscopic and single c...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.09.015
更新日期:2003-11-01 00:00:00
abstract::Peptides spanning the range of human parathyroid hormone-related protein (PTHrP) have been shown to bind heat shock protein-70 expressed on the surface of cancer cells with cytoprotective consequences in vitro. The present study focused on identification of intracellular proteins that interact with the carboxy-termina...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.01.015
更新日期:2006-07-01 00:00:00
abstract::Scorpion venoms are rich sources of biologically active peptides that are classified into disulfide-bridged peptides (DBPs) and non-disulfide-bridged peptides (NDBPs). DBPs are the main scorpion venom components responsible for the neurotoxic effects observed during scorpion envenomation as they usually target membran...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2013.10.021
更新日期:2014-01-01 00:00:00
abstract::The leucosulfakinins (LSKs), isolated from head extracts of the cockroach Leucophaea maderae, are sulfated neuropeptides with homology to gastrin and cholecystokinin. The undecapeptide LSK and decapeptide LSK-II stimulate contractions of the isolated cockroach hindgut. Several structural aspects of the two gastrin/CCK...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90237-9
更新日期:1988-01-01 00:00:00
abstract::The effects of hypergravity on the gene expression of the hypothalamic feeding-related neuropeptides in sham-operated (Sham) and vestibular-lesioned (VL) mice were examined by in situ hybridization histochemistry. Corticotrophin-releasing hormone (CRH) in the paraventricular nucleus was increased significantly in Sham...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.05.004
更新日期:2018-07-01 00:00:00
abstract::Endogenous hemorphins, derived from degradation of the beta-chain of hemoglobin, lower arterial blood pressure and exert an antinociceptive action in experimental models of nociception. Hemopressin, derived from the alpha-chain of hemoglobin, also decreases blood pressure, but its effects on pain have not been studied...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.10.026
更新日期:2005-03-01 00:00:00
abstract::Two cDNAs, size 969 bp and 1146 bp respectively, encoding goldfish gamma-preprotachykinin (gamma-PPT) were identified. Both cDNAs contain the same 345 bp open reading frame. The deduced 114-amino acid gamma-PPT contains the sequence of substance P, carassin and neurokinin A. sequence analysis of the two cDNA 5'-untran...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00013-2
更新日期:1997-01-01 00:00:00
abstract::To characterize the endothelin (ET) receptor that mediates the contraction induced by ET-1 in the porcine myometrium, we carried out a contraction study, radioligand binding study and molecular study (reverse transcription polymerase chain reaction) for detection of ET receptor-coding genes (mRNA). ET-1 (1 nM-1 microM...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00169-8
更新日期:2000-04-01 00:00:00
abstract::Recent refinements in methodology now permit the study of endogenous peptide hormones in their individual target cells. The investigations reported here deal with the question of whether endogenous ACTH can be detected in its target cells in the highly active adrenal gland of the normally lactating rat. This question ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(80)90062-5
更新日期:1980-10-01 00:00:00
abstract::Calcitonin gene-related peptide (CGRP) immunoreactive material has been found in extracts of the intestine, however, the structure of intestinal CGRP is not known. Analytical reverse phase HPLC and ion-exchange FPLC revealed one predominant immunoreactive CGRP peak in rabbit intestinal extracts. This material was puri...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90014-g
更新日期:1991-03-01 00:00:00
abstract::In the adrenal gland all components of the renin-angiotensin system (RAS) are expressed in both the adrenal cortex and the adrenal medulla. In this review evidence shall be presented that a local secretory RAS exists in the adrenal cortex that stimulates aldosterone production and serves as an amplification system for...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2012.01.023
更新日期:2012-04-01 00:00:00
abstract::VIP stimulates adenylate cyclase activity of male and female rat anterior pituitaries and human prolactinomas, while dopamine inhibits the enzyme activity of female rat pituitaries and prolactinomas. A dopamine inhibited cyclase can be detected also in male rats provided the enzyme activity is increased by VIP. The an...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90172-4
更新日期:1984-11-01 00:00:00
abstract::Immunocytochemistry using an antiserum to the C-terminal octapeptide of synenkephalin, proenkephalin(63-70), was performed throughout the rat brain and revealed numerous immunopositive fibers and some cell bodies. The morphology and distribution of synenkephalin immunoreactivity was extremely similar to that of a comm...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90018-1
更新日期:1989-11-01 00:00:00