Abstract:
:Two cDNAs, size 969 bp and 1146 bp respectively, encoding goldfish gamma-preprotachykinin (gamma-PPT) were identified. Both cDNAs contain the same 345 bp open reading frame. The deduced 114-amino acid gamma-PPT contains the sequence of substance P, carassin and neurokinin A. sequence analysis of the two cDNA 5'-untranslated regions shows that the two cDNAs may represent different PPT-A gene transcripts resulting from the alternative transcriptional start sites. Expression of gamma-PPT mRNA was detected in a wide range of brain areas from the olfactory bulbs to the posterior brain region, as well as in the intestine, testis and pituitary.
journal_name
Peptidesjournal_title
Peptidesauthors
Lin XW,Peter REdoi
10.1016/s0196-9781(97)00013-2subject
Has Abstractpub_date
1997-01-01 00:00:00pages
817-24issue
6eissn
0196-9781issn
1873-5169pii
S0196-9781(97)00013-2journal_volume
18pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::The distribution of neurokinin B (NKB) was determined by immunocytochemistry with antisera directed toward its amino terminus. Immunoreactive perikarya were detected in the main and accessory olfactory bulbs, cortical regions, the olfactory tubercle, the bed nucleus of the stria terminalis, the diagonal band of Broca,...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90192-6
更新日期:1992-07-01 00:00:00
abstract::Cationic lytic-type peptides have been studied for clinical application in various infections and cancers. This study aimed to determine the functions of our specially designed lytic peptide. To investigate the functional mechanism at the cell membrane level, we used giant unilayer vesicles (GUVs) mimicking cell membr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.09.015
更新日期:2013-12-01 00:00:00
abstract::Milk is one of the main source of biologically-active peptides that may function as regulatory substances called food hormones. After passing the gut-blood barrier, the μ-opioid receptor agonist and antagonist peptides may become the new factors influencing various functions of the human organism. The aim of the condu...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.12.003
更新日期:2011-04-01 00:00:00
abstract::Histidyl-proline diketopiperazine (cyclo(His-Pro), a metabolite of the neuropeptide thyrotropin releasing hormone, has been shown to possess intrinsic biological activities. The binding of this peptide to various tissue particulate preparations was investigated. While the peptide showed no apparent binding to particul...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90172-9
更新日期:1983-01-01 00:00:00
abstract::The gut-derived hormone peptide YY (PYY) is most commonly known for its effect on satiety, decreasing food intake and body weight in animals and humans. However, PYY is also involved in a wide range of digestive functions including regulating insulin secretion and glucose homeostasis. Over the last few years, there ha...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2006.07.031
更新日期:2007-02-01 00:00:00
abstract::Immunoreactive alpha-MSH was found in human skin and the skin of numerous other mammals. After hypophysectomy the concentration of alpha-MSH in rat skin showed little change suggesting that the pituitary is not the source of this MSH. In human skin the highest concentration was found in the epidermis and HPLC revealed...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90072-4
更新日期:1983-11-01 00:00:00
abstract::To study the effects of inducing stereo-chemical modifications in the structure of dermorphin (DM) so as to improve its mu-opioid receptor affinity and its resistance to C-terminal enzymatic degradation, in the Institute of Molecular Genetics of Moscow, we synthesized a new DM analogue ([DPro(6)]DM) and analyzed the c...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(03)00057-3
更新日期:2003-03-01 00:00:00
abstract::Vestibular compensation is a process of CNS plasticity that is correlated to a return of resting activity in medial vestibular nucleus (MVN) neurons ipsilateral to a peripheral vestibular deafferentation. Systemic administration of melanocortin peptides accelerates the compensation process; the ACTH/MSH(4-9) analogue,...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00021-6
更新日期:1996-01-01 00:00:00
abstract::Endocrine tumor cells in culture and in vitro cleavage assays have shown that PC1 and PC2 are capable of processing pro-CCK into smaller, intermediate and final, bioactive forms. Similar studies have shown that PC5 has the ability to process a number of propeptides. Here, we use GT1-7 (mouse hypothalamic) and SK-N-MC ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00451-x
更新日期:2001-08-01 00:00:00
abstract::alpha-MSH immunoreactive peptides were fractionated and characterized in rat and human brain and rat pituitary by reversed phase high pressure liquid chromatographic techniques. alpha-MSH and deacetylated alpha-MSH were two major naturally existing peptides in both brain and pituitary gland. Subsequent experiments exa...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(81)80126-x
更新日期:1981-10-01 00:00:00
abstract::The neuropharmacological basis for d-amphetamine induced paradoxical behavioral thermoregulation remains unclear. This study examined thermoregulatory behavior of rats in a runway device that housed a heat source at one end and in which locomotion along the length of the runway could be observed. Sprague Dawley rats w...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90038-5
更新日期:1985-03-01 00:00:00
abstract::Strips of lower esophageal sphincter (LES) from rabbits were tested for their responses to several peptides, and to electrical field stimulation (EFS) under the presence of some peptides. Substance P (SP), motilin, and bombesin induced contraction, and vasoactive intestinal peptide (VIP) induced relaxation. SP- and bo...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00137-4
更新日期:1996-01-01 00:00:00
abstract::The temporins are a family of hydrophobic, C-terminally alpha-amidated antimicrobial peptides that are synthesized in the skins of a wide range of species of frogs belonging to the genus Rana. In the present study, we investigated using RT-PCR the expression of preprotemporin mRNAs in extradermal tissues of Tago's bro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.03.023
更新日期:2006-09-01 00:00:00
abstract::VIP and secretin control the secretory function of the normal pancreas. We analysed their regulatory functions in a human pancreatic cancer cell line: Capan-1. Saturation binding experiments with 125I-VIP showed the existence of one class of binding sites of very high affinity: KD 6.4 +/- 3.0 X 10(-11) M and a low Bma...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90200-7
更新日期:1986-01-01 00:00:00
abstract::Echinometra lucunter is an abundant sea urchin found in Brazilian waters. Accidents caused by this animal are common and are characterized by the penetration of the spines in the skin, which raises an inflammatory reaction through mechanical trauma as well as by the presumable action of toxins. Additionally, there hav...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.07.031
更新日期:2014-03-01 00:00:00
abstract::Cholecystokinin (CCK) and met-enkephalin (MEK) related peptides have been shown to alter feeding behavior subsequent to their injection into the peripheral circulation or directly into the brains of several species. To evaluate the potential role of endogenous brain pools of these peptides in feeding, groups of sheep ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90325-0
更新日期:1985-09-01 00:00:00
abstract::We found that neurokinin A (NKA) and neurokinin B (NKB) induce an increase in the concentration of intracellular free Ca2+ ([Ca2+]i) in murine neuroblastoma C1300 cells (EC50: NKA 87 +/- 13 nM, NKB 97 +/- 15 nM). Substance P (SP) also caused a transient Ca2+ increase, although the potency of SP was much less than that...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)00166-9
更新日期:1995-01-01 00:00:00
abstract::C-type natriuretic peptide (CNP) stimulates endochondrial ossification by activating the transmembrane guanylyl cyclase, natriuretic peptide receptor-B (NPR-B). Recently, a spontaneous autosomal recessive mutation that causes severe dwarfism in mice was identified. The mutant, called long bone abnormality (lbab), cont...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.04.020
更新日期:2008-09-01 00:00:00
abstract::Neuropeptide Y (NPY) induces feeding in previously satiated animals after injection into the hypothalamus, especially the perifornical region (PFH). NPY also appears to have rewarding properties as evidenced by its ability to produce a conditioned place preference following injection into the nucleus accumbens (N.Acc)...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00117-x
更新日期:1998-01-01 00:00:00
abstract::Marine snails of the genus Conus (∼500 species) are tropical predators that produce venoms for capturing prey, defense and competitive interactions. These venoms contain 50-200 different peptides ("conotoxins") that generally comprise 7-40 amino acid residues (including 0-5 disulfide bridges), and that frequently cont...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2014.01.018
更新日期:2014-03-01 00:00:00
abstract::Receptor binding analysis was performed in the renal medulla from 2-month-old rats, an extrapituitary tissue containing the highest level of GHRH receptor mRNA. At 4 degrees C, in the presence of a cocktail of protease inhibitors, binding of [125I-Tyr(10)]hGHRH (1-44)NH(2) to medullary homogenates was specific, time-d...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00029-3
更新日期:2002-06-01 00:00:00
abstract::MPF is a tetrapeptide (structure Lys-Lys-Gly-Glu) that elicits a variety of neurotrophic effects in vivo consistent with a role in neuronal regeneration. In support of this role, we now show that MPF stimulates the proliferation of cultured astrocytes and neurite outgrowth from cultures of neocortical cholinergic and ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00043-0
更新日期:1997-01-01 00:00:00
abstract::Brazilian freshwater stingrays, Potamotrygon gr. orbigyni, are relatively common in the middle-western regions of Brazil, where they are considered an important public health threat. In order to identify some of their naturally occurring toxin peptides available in very low amounts, we combine analytical protocols suc...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.08.004
更新日期:2009-12-01 00:00:00
abstract::In a previous study, we found that calcitonin gene-related peptide (CGRP) could be induced by proinflammatory factor IL-1beta in A549 human type II alveolar (AEII) epithelial cells. We investigated the mechanism of IL-1beta-induced CGRP secretion and found that the PKC-p38 MAPK-NF-kappaB pathway was involved. In the p...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.03.021
更新日期:2007-06-01 00:00:00
abstract::Members of the neprilysin family of neutral endopeptidases (M13) are typically membrane-bound enzymes known to be involved in the extra-cellular metabolism of signalling peptides and have important roles during mammalian embryogenesis. In this study we show that membranes prepared from embryos of Drosophila melanogast...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.08.032
更新日期:2007-01-01 00:00:00
abstract::C-type natriuretic peptide (CNP) significantly increases in chronic heart failure (CHF) patients as a function of clinical severity. Aim of this study was to evaluate in CHF patients the relationship between circulating CNP concentrations and echo-Doppler conventional indices of left ventricular (LV) function as well ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.10.022
更新日期:2008-01-01 00:00:00
abstract::The synthesis is described of an analogue of the locust CRF-like diuretic peptide in which methionine in positions 1,3, and 13 is replaced by isosteric methyl-homoserine residues. This analogue has been tested for biological activity on Malpighian tubules in vitro, and feeding behavior in vivo. It is highly active in ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.09.010
更新日期:2003-10-01 00:00:00
abstract::Arginine-vasopressin (AVP) is a hypothalamic hormone that, like CRH, stimulates the pituitary release of ACTH, thereby activating adrenal glucocorticoid secretion. Evidence indicates that rat adrenal medulla contains a CRH-ACTH system duplicating that existing at the hypothalamo-pituitary level and involved in the par...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(96)00294-x
更新日期:1997-01-01 00:00:00
abstract::Peptic digestion of bovine hemoglobin at low degree of hydrolysis yields an intermediate peptide fraction exhibiting antibacterial activity against Micrococcus luteus A270, Listeria innocua, Escherichia coli and Salmonella enteritidis after separation by reversed-phase HPLC. From this fraction a pure peptide was isola...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.12.008
更新日期:2005-05-01 00:00:00
abstract::Neurotensin has been demonstrated to be analgesic in rodents. This study used intrathecal injection of neurotensin in unanesthetized mice to evaluate the effect of the peptide at the spinal level on unconditioned behavior. Intrathecal administration of neurotensin produced dose-related inhibition of locomotor activity...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90057-8
更新日期:1983-07-01 00:00:00