Abstract：
:MPF is a tetrapeptide (structure Lys-Lys-Gly-Glu) that elicits a variety of neurotrophic effects in vivo consistent with a role in neuronal regeneration. In support of this role, we now show that MPF stimulates the proliferation of cultured astrocytes and neurite outgrowth from cultures of neocortical cholinergic and mesenchephalic dopaminergic neurons. The dose-response relationships are biphasic ("bell shaped"), maximal responses being obtained with 10(-6) M concentrations of MPF. MPF and nerve growth factor seem to act on different receptors, because their effects on cholinergic neurons are synergistic.
journal_name
Peptidesjournal_title
Peptidesauthors
Owen DB,Morley JS,Ensor DM,Allen YS,Miles JBdoi
10.1016/s0196-9781(97)00043-0subject
Has Abstractpub_date
1997-01-01 00:00:00pages
1015-21issue
7eissn
0196-9781issn
1873-5169pii
S0196-9781(97)00043-0journal_volume
18pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:An important role for angiotensin IV (Ang IV) in the processes of learning and memory has now been well established. We have previously found that intracerebroventricular (ICV) administration of Ang IV as well as des-Phe6-Ang IV enhances learning of conditioned avoidance responses (CARs), facilitates recall of a passi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.04.014
更新日期：2004-07-01 00:00:00
abstract：:Antibodies to the extreme C-terminal pentapeptide of procholecystokinin, YEYPS (in the single letter notation), have been used in radioimmunoassay and immunohistochemistry to characterize the material in rat intestine. There is a single major immunoreactive peptide in intestinal extracts that has the properties of the...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(87)90170-7
更新日期：1987-01-01 00:00:00
abstract：:Pea albumin 1F (PA1F), a plant peptide isolated from pea seeds, can dramatically increase blood glucose concentration by subcutaneous injection with a dosage of 5 or 10 microg/g (body weight) in normal and type II diabetic mice (KK/upj-Ay). The voltage-dependent anion channel 1 (VDAC-1) has been identified as the PA1F...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.01.013
更新日期：2008-06-01 00:00:00
abstract：:A comparison of the conformational characteristics of the related hormones [Nle(15)] gastrin-17 and [Tyr(9)-SO(3)] cholecystokinin-15, in membrane-mimetic solutions of dodecylphosphocholine micelles and water, was undertaken using NMR spectroscopy to investigate the possibility of a structural motif responsible for th...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.09.008
更新日期：2007-11-01 00:00:00
abstract：:NPFF receptors are expressed in several brain regions directly or indirectly involved in cognition and behavior. However, the cognitive effects of the NPFF system have been poorly studied. Therefore, the aim of our study was to analyze the effects of i.c.v. injections of 1 DMe, a stable agonist of NPFF receptors, on b...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.11.009
更新日期：2010-02-01 00:00:00
abstract：:Prolactin (PRL) is known to exert neuroprotective effects against excitotoxic damage in the hippocampus of female rats, both in vitro and in vivo. It is still unknown whether this effect can be seen in the male hippocampus and intracellular signaling mediating such action. To assess this, adult male CD-1 mice were sub...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2020.170425
更新日期：2021-01-01 00:00:00
abstract：:Bombesin is a tetradecapeptide heterogenously distributed in the mammalian brain. Bombesin (45 micrograms) given intracisternally (IC) to unanesthetized rats increased the accumulation of dihydroxyphenylalanine (DOPA) in striatum, olfactory tubercles and hypothalamus after DOPA-decarboxylase inhibition, thus indicatin...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90081-0
更新日期：1984-05-01 00:00:00
abstract：:In addition to wasp kinins, the wasp venom contains a series of hydrophobic peptides, mastoparans and chemotactic peptides as major peptidergic components. The first major component in the venom is mastoparam. The peptides in the mastoparan family are tetradecapeptide amides which cause degranulation of the mast cells...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90409-7
更新日期：1985-01-01 00:00:00
abstract：:VIP stimulates adenylate cyclase activity of male and female rat anterior pituitaries and human prolactinomas, while dopamine inhibits the enzyme activity of female rat pituitaries and prolactinomas. A dopamine inhibited cyclase can be detected also in male rats provided the enzyme activity is increased by VIP. The an...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90172-4
更新日期：1984-11-01 00:00:00
abstract：:A novel protease inhibitor, designated mungoin, with both antifungal and antibacterial activities, and exhibiting a molecular mass of 10kDa in SDS-polyacrylamide gel electrophoresis, was isolated from mung bean (Phaseolus mungo) seeds. The isolation procedure involved a combination of extraction, ammonium sulfate prec...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.07.013
更新日期：2006-12-01 00:00:00
abstract：:By using specific antibodies and radioimmunological and immunohistochemical methods, we here show that neuropeptide FF (NPFF) occurs in cervical and lumbar dorsal root ganglia cells. Levels in the ganglia were low because they were detectable only after colchicine treatment or after unilateral dorsal rhizotomy. Simila...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00039-x
更新日期：1999-01-01 00:00:00
abstract：:The effect of arginine vasopressin (AVP) on rat antinociception was investigated. Intraventricular injection of 50 or 100 ng AVP dose-dependently increased the pain threshold; in contrast, intraventricular injection of 10 microl anti-AVP serum decreased the pain threshold; both intrathecal injection of 200 ng AVP or 1...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.08.019
更新日期：2006-12-01 00:00:00
abstract：:The present study demonstrates the occurrence of substance P (SP)- and calcitonin gene related peptide (CGRP)-immunoreactive nerve fibres in bone, bone marrow, periosteum, synovial membrane and soft tissues adjacent to the bone. The distribution pattern of the two types of nerves was similar, although the CGRP-positiv...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(88)90023-x
更新日期：1988-01-01 00:00:00
abstract：:Urotensin II (U-II) is a vasoactive peptide with many potent effects in the cardiorenovascular system. U-II activates a G-protein-coupled receptor termed UT. UT and U-II are highly expressed in the cardiovascular and renal system. Patients with various cardiovascular diseases show high U-II plasma levels. It was demon...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2007.08.029
更新日期：2008-05-01 00:00:00
abstract：:Bradykinin (BK) has been proposed as the principal mediator of hypersensitivity reactions (HSR) in patients dialyzed using negatively charged membranes and concomitantly treated with angiotensin-converting enzyme (ACE) inhibitors. We investigated the metabolism of exogenous BK added to the sera of 13 patients dialyzed...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00020-0
更新日期：1999-01-01 00:00:00
abstract：:Tachykinins are multifunctional neuropeptides that have been identified in vertebrates as well as invertebrates. The C-terminal FXGXRa-motif constitutes the consensus active core region of invertebrate tachykinins. In Drosophila, two putative G protein-coupled tachykinin receptors have been cloned: DTKR and NKD. This ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.06.014
更新日期：2007-01-01 00:00:00
abstract：:Large species differences have been previously observed in the pharmacology of bradykinin (BK) B2 receptor antagonists. We investigated the effect of two novel non-peptide antagonists, compound 9 (a benzodiazepine peptidomimetic related to icatibant) and the thiosemicarbazide bradyzide on the rabbit B2 receptor (contr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(01)00481-8
更新日期：2001-09-01 00:00:00
abstract：:Obestatin is purported to be a peptide hormone encoded in preproghrelin. We studied the metabolic effects of continuous infusion of obestatin via subcutaneously implanted osmotic mini-pumps. Administration of up to 500nmol/kg body weight/day obestatin did not change 24h cumulative food intake or body weight in rats. S...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.03.023
更新日期：2008-08-01 00:00:00
abstract：:Prolactin releasing peptide (PrRP) was originally reported to act in the anterior lobe of the pituitary gland to stimulate prolactin (PRL) release; however, numerous other pharmacologic actions of PrRP have been described. In the central nervous system PrRP inhibits food intake, stimulates sympathetic tone, and activa...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.01.008
更新日期：2006-05-01 00:00:00
abstract：:Smooth muscle cells isolated by enzymatic digestion were used to determine the direct effects of galanin on circular and longitudinal muscle layers from dog proximal colon and to investigate the intracellular pathways involved in these effects. Effects of galanin were compared to those observed with other contracting ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90088-4
更新日期：1994-01-01 00:00:00
abstract：:Glucagon-like peptide-1 (GLP-1) is a proglucagon-derived hormone with cellular protective actions. We hypothesized that GLP-1 would protect the endothelium from injury during inflammation. Our aims were to determine the: (1) effect of GLP-1 on basal microvascular permeability, (2) effect of GLP-1 on increased microvas...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.06.019
更新日期：2009-09-01 00:00:00
abstract：:An immunohistochemical mapping study in the brain and upper spinal cord of the turtle Testudo hermanni Gmelin revealed a wide distribution of somatostatin perikarya and fibres. Within the telencephalon, somatostatin perikarya are present in the anterior olfactory nucleus, in the medial, dorsomedial and dorsal cortex, ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90268-7
更新日期：1984-01-01 00:00:00
abstract：:The emergence of multidrug-resistant strains of Neisseria gonorrhoeae constitutes a serious threat to public health and necessitates the discovery of new types of antimicrobial agents. Among the 18 clinical isolates of N. gonorrhoeae with susceptible to spectinomycin, ceftriaxone and cefixime, 14 isolates were resista...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.10.020
更新日期：2014-03-01 00:00:00
abstract：:The teleost salmon calcitonin (sCT), but not mammalian CT, shows similar biologic actions in the skeletal muscle as amylin and calcitonin gene-related peptide (CGRP). The peptides have also been shown to reduce food intake in rams. Because sCT, but not amylin, binds irreversibly to amylin binding sites, the aim of the...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00208-9
更新日期：2000-02-01 00:00:00
abstract：:To investigate possible influences of growth hormone-releasing hormone (GHRH) and somatostatin (SRIF) on auditory perceptional processes, 12 subjects received either placebo (sodium chloride 0.9%), GHRH (50 micrograms), or SRIF (100 micrograms) on different days. Late auditory evoked potentials (AEP) were computed and...
journal_title：Peptides
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0196-9781(95)00024-e
更新日期：1995-01-01 00:00:00
abstract：:The presence of alpha-hANP immunoreactive material in human heart and plasma was investigated with a specific and sensitive radioimmunoassay and immunohistochemical method. It was found that alpha-hANP immunoreactive staining of specific atrial granules was located around the nucleus of atrial cardiocytes. No immunore...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90057-4
更新日期：1986-01-01 00:00:00
abstract：:Brain-derived neurotrophic factor-like neuropeptide is produced in the brain of the silk moth, Bombyx mori. Immunocytochemical studies of brain and retrocerebral complex of larvae, prepupae, pupae and adults showed that four pairs of median neurosecretory cells and six pairs of lateral neurosecretory cells which had d...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.07.005
更新日期：2004-11-01 00:00:00
abstract：:The identification and characterization of hypothetical membrane proteins from Mycobacterium tuberculosis have led to a better understanding of the mechanisms used by this pathogen to invade and survive inside host cells. This study assessed the presence, transcription, localization and possible biological activity of...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.09.017
更新日期：2011-01-01 00:00:00
abstract：:The in vitro interaction between five polycationic peptides, buforin II, cecropin P1, indolicidin, magainin II, and ranalexin, and several clinically used antimicrobial agents was evaluated against several clinical isolates of Gram-positive and Gram-negative aerobic bacteria, using the microbroth dilution method. The ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00254-0
更新日期：2000-08-01 00:00:00
abstract：:Calcification-associated peptide (CAP)-1 is considered to play an important role in calcification of the exoskeleton of the crayfish, Procambarus clarkii. In this study, in order to clarify the molecular mechanism of calcification, we constructed expression systems of recombinant molecules of CAP-1 and its related pep...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.12.005
更新日期：2007-03-01 00:00:00
