Cardiorenovascular effects of urotensin II and the relevance of the UT receptor.

abstract：:Catestatin (CST) is an endogenous neuropeptide with multiple cardiovascular activities. The study is to investigate circulating CST levels in heart failure (HF) patients and to evaluate the role of CST as a biomarker for HF. Plasma CST concentrations were measured by enzyme-linked immunosorbent assay in 228 HF patient...

journal_title：Peptides

authors： Liu L,Ding W,Li R,Ye X,Zhao J,Jiang J,Meng L,Wang J,Chu S,Han X,Peng F

更新日期：2013-08-01 00:00:00

abstract：:Nociceptin/orphanin FQ (NC), the endogenous ligand of the opioid receptor-like1 (ORL1) receptor, has been reported to stimulate feeding in rats. The present article reviews the studies so far published on the effect of NC on food intake and reports new findings concerning the sensitivity of brain regions to the hyperp...

journal_title：Peptides

authors： Polidori C,de Caro G,Massi M

更新日期：2000-07-01 00:00:00

abstract：:The chronic hyperglycemia measured alongside diabetes development is associated with significant long-term damage and failure of various organs. In the present study it was shown that hyperglycemia induced early and long term increases in nitric oxide (NO) levels, kallikrein activity and vascular capillary permeabilit...

journal_title：Peptides

authors： Catanzaro O,Labal E,Andornino A,Capponi JA,Di Martino I,Sirois P

更新日期：2012-04-01 00:00:00

abstract：:Selective GLP-1 secretagogues represent a novel potential therapy for type 2 diabetes mellitus. This study examined the GLP-1 secretory activity of the ethnomedicinal plant, Fagonia cretica, which is postulated to possess anti-diabetic activity. After extraction and fractionation extracts and purified compounds were t...

journal_title：Peptides

authors： Jafri L,Saleem S,Calderwood D,Gillespie A,Mirza B,Green BD

更新日期：2016-04-01 00:00:00

abstract：:The Y5 receptor has been postulated to be the main receptor mediating NPY-induced food intake in rats, based on its pharmacological profile and mRNA distribution. To further characterize this important receptor subtype, we isolated the Y5 gene in the guinea pig, a widely used laboratory animal in which all other known...

journal_title：Peptides

authors： Lundell I,Eriksson H,Marklund U,Larhammar D

更新日期：2001-03-01 00:00:00

abstract：:Heparin-binding EGF-like growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, can protect intestinal epithelial cells from various forms of injury in vitro and attenuate intestinal ischemia/reperfusion damage in vivo. With the goal of eventual clinical use of HB-EGF to protect the intestines f...

journal_title：Peptides

authors： Feng J,Mehta VB,El-Assal ON,Wu D,Besner GE

更新日期：2006-06-01 00:00:00

abstract：:Osmotic stress stimulates the release of the avian hypothalamic neuropeptide arginine vasotocin (AVT) into the peripheral circulation. We conducted the present study to investigate the effects of salt-loading on AVT secretion and AVT gene expression in specific hypothalamic nuclei in chickens. White Leghorn chickens w...

journal_title：Peptides

authors： Chaturvedi CM,Cornett LE,Koike TI

更新日期：1997-01-01 00:00:00

abstract：:The effects of amiloride on ANF binding and ANF stimulation of cGMP were evaluated in rat glomeruli. Amiloride increased ANF binding to whole glomeruli and to glomerular membrane preparations. In contrast, amiloride enhanced ANF-stimulated cGMP accumulation only at 37 degrees C in whole glomeruli, but not at 4 degrees...

journal_title：Peptides

authors： Iwata T,Hardee E,Frohlich ED,Cole FE

更新日期：1989-05-01 00:00:00

abstract：:The presence of atrial natriuretic peptide (ANP) binding sites in the thymic cortex, medulla, and splenic white pulp suggests that this peptide may have immunoregulatory activity. We examined the effect of ANP on human natural killer (NK) cell activity. ANP significantly augmented NK cell cytotoxicity after twenty-fou...

journal_title：Peptides

authors： Moss RB,Golightly MG

更新日期：1991-07-01 00:00:00

abstract：:Previous reports have demonstrated that systemic injection of cholecystokinin (CCK) in rats produces dose-related decreases in food intake, increases in neurohypophyseal secretion of oxytocin (OT), and decreases in gastric emptying. The present studies determined whether systemic injection of bombesin (BBS), another p...

journal_title：Peptides

authors： Verbalis JG,McCann MJ,Stricker EM

更新日期：1988-11-01 00:00:00

abstract：:Quantitative receptor autoradiography using Bolton-Hunter iodinated substance P (SP) was used to localize specific sites in the rat hypothalamus. The amount of SP and neurokinin A (NkA) in extracts from discrete areas of the hypothalamus was measured using specific radioimmunoassays. A high density of SP binding sites...

journal_title：Peptides

authors： Larsen PJ,Jessop DS,Chowdrey HS,Mikkelsen JD,Lightman SL

更新日期：1992-07-01 00:00:00

abstract：:WH1fungin, a surfactin cyclopeptide from Bacillus amyloliquefaciens WH1, is firstly reported as a novel immunoadjuvant, which can markedly enhance the immune response when given in mixture with antigens. After intramuscular or subcutaneous immunization, WH1fungin can help to induce both of durable humoral and cellular...

journal_title：Peptides

authors： Gao Z,Wang S,Qi G,Pan H,Zhang L,Zhou X,Liu J,Zhao X,Wu J

更新日期：2012-11-01 00:00:00

abstract：:Cardiac hypertrophy, an adaptive process to an increased hemodynamic overload, includes not only an increase in cell size but also qualitative changes in constituent proteins. Although swelling-activated chloride channels (I(Cl,swell)) chronically activate in hypertrophied atrial myocytes, the role of I(Cl,swell) in r...

journal_title：Peptides

authors： Bai GY,Yuan K,Park WH,Kim SZ,Kim SH

更新日期：2008-09-01 00:00:00

abstract：:In non-pregnant goats, ovariectomy on day 12 of oestrous cycle resulted in parallel decrease of oxytocin and progesterone jugular concentration. Similarly, luteolysis, indicated by decreasing progesterone concentration, was accompanied by simultaneous release of oxytocin and oxytocin-associated neurophysins (mean of n...

journal_title：Peptides

authors： Homeida AM

更新日期：1987-09-01 00:00:00

abstract：:Originally characterized in terms of its gastric acid inhibitory properties, GIP (gastric inhibitory polypeptide) expressed in the upper small intestine, was subsequently shown to exert strong glucose-dependent insulin-releasing properties. This action is generally attributed to GIP(1-42) and, so far, no evidence for ...

journal_title：Peptides

authors： Fehmann HC,Göke B

更新日期：1995-01-01 00:00:00

abstract：:The definitive function of pancreatic polypeptide in mammalian physiology remains unknown. The identification of specific PP target tissues should be helpful to further investigations into the possible regulatory actions of this peptide. An in vivo radioreceptor assay was used in the rat to locate potential binding si...

journal_title：Peptides

authors： Shetzline MA,Zipf WB,Nishikawara MT

更新日期：1998-01-01 00:00:00

abstract：:The family of natriuretic peptides (NPs) discovered in mammalian tissues including cardiac atrium and brain consists of three members, namely, atrial, B- and C-type natriuretic peptides (ANP, BNP, CNP). Since the discovery, basic and clinical studies have been vigorously performed to explore the biological functions a...

journal_title：Peptides

authors： Kato J

更新日期：2020-10-01 00:00:00

abstract：:Previous corticotropin releasing factor 1 (CRF1) receptor characterization has been performed using radiolabeled agonists, which bind predominantly the receptor-G-protein complex. The pharmacological profile of other receptor states, and their abundance, remain poorly characterized. Here we investigated the affinity s...

journal_title：Peptides

authors： Hoare SR,Sullivan SK,Pahuja A,Ling N,Crowe PD,Grigoriadis DE

更新日期：2003-12-01 00:00:00

abstract：:N-hydroxysuccinimide (NHS) esters of biotin are reported to react specifically with amino groups of peptides and proteins. However, we have found that these reagents can readily acylate other functional groups in specific peptide sequences under relatively mild conditions. We have extended our inquiry of sequence-depe...

journal_title：Peptides

authors： Miller BT,Collins TJ,Rogers ME,Kurosky A

更新日期：1997-01-01 00:00:00

abstract：:Female Zucker lean and obese rats were treated for 14 days with 3.5 micromol/kg oleoyl-estrone (OE) in liposomes (Merlin-2). After 0, 3, 6, 10, and 14 days of treatment, the rats were killed and hypothalamic nuclei (lateral preoptic, median preoptic, paraventricular, ventromedial and arcuate) were used for neuropeptid...

journal_title：Peptides

authors： Cabot C,Grasa MM,Adán C,Pérez-Clausell J,Virgili J,Estruch J,Fernández-Löpez JA,Remesar X,Alemany M

更新日期：1998-01-01 00:00:00

abstract：:A sparse to moderate supply of nerve fibers containing neuropeptide Y-like immunoreactivity (NPY-LI), vasoactive intestinal polypeptide (VIP-LI), substance P (SP-LI), and calcitonin gene-related peptide (CGRP-LI) was demonstrated in the walls of human middle meningeal arteries. Comparison with similar studies on human...

journal_title：Peptides

authors： Jansen I,Uddman R,Ekman R,Olesen J,Ottosson A,Edvinsson L

更新日期：1992-05-01 00:00:00

abstract：:The teleost salmon calcitonin (sCT), but not mammalian CT, shows similar biologic actions in the skeletal muscle as amylin and calcitonin gene-related peptide (CGRP). The peptides have also been shown to reduce food intake in rams. Because sCT, but not amylin, binds irreversibly to amylin binding sites, the aim of the...

journal_title：Peptides

authors： Lutz TA,Tschudy S,Rushing PA,Scharrer E

更新日期：2000-02-01 00:00:00

abstract：:Milk is the best, complete food important for the development and nourishment of a neonate. Except for nutrients, milk contains biologically active opioid peptides derived from beta-casein, named beta-casomorphins (BCMs), which can exert effects in the gastrointestinal tract as well as in the whole body of neonates. T...

journal_title：Peptides

authors： Jarmołowska B,Sidor K,Iwan M,Bielikowicz K,Kaczmarski M,Kostyra E,Kostyra H

更新日期：2007-10-01 00:00:00

abstract：:Humanin (HN) and its analogues have been shown to protect cells against death induced by various Alzheimer's disease (AD) genes and amyloid-beta-peptides in vitro; the analogues [Gly(14)]-HN and colivelin have also been shown to be potent in reversing learning and memory impairment induced by scopolamine or quinuclidi...

journal_title：Peptides

authors： Kunesová G,Hlavácek J,Patocka J,Evangelou A,Zikos C,Benaki D,Paravatou-Petsotas M,Pelecanou M,Livaniou E,Slaninova J

更新日期：2008-11-01 00:00:00

abstract：:We measured the concentration of beta-endorphin (beta-End) in plasma, as well as in aqueous humor and crystalline lens removed during cataract surgery. beta-End was detected both in the aqueous humor and in the crystalline lens. The concentration of beta-End in the aqueous humor corresponded to almost the half of the ...

journal_title：Peptides

authors： Bender T,Török I,Barna I,Géher P

更新日期：2001-04-01 00:00:00

abstract：:The prothoracicotropic hormones (PTTH) are cerebral peptides that control insect postembryonic development by stimulating the prothoracic glands to synthesize ecdysteroids. Using immunoaffinity chromatography and SDS-PAGE, a 25.5 kDa big PTTH has been purified from Manduca sexta. Based upon SDS-PAGE and Western blot a...

journal_title：Peptides

authors： Muehleisen DP,Gray RS,Katahira EJ,Thomas MK,Bollenbacher WE

更新日期：1993-05-01 00:00:00

abstract：:A neuropeptide F (NPF) was isolated from the fruit fly, Drosophila mellanogaster, based on a radioimmunoassay for a gut peptide from the corn earworm, Helicoverpa zea. A partial sequence was obtained from the fly peptide, and a genomic sequence coding for NPF was cloned after inverse polymerase chain reaction and show...

journal_title：Peptides

authors： Brown MR,Crim JW,Arata RC,Cai HN,Chun C,Shen P

更新日期：1999-01-01 00:00:00

abstract：:CRF injected into the third cerebral ventricle (0.5-2.5 micrograms) caused dose-related reductions in fever induced in rabbits by IV administration of leukocytic pyrogen. Control injections of CRF when the same animals were afebrile did not alter normal body temperature. Intravenous injections of 5 and 20 micrograms C...

journal_title：Peptides

authors： Bernardini GL,Richards DB,Lipton JM

更新日期：1984-01-01 00:00:00

abstract：:Immunohistochemical studies were conducted on sections of cat hypothalamus in order to determine the distribution of neurons containing alpha-melanocyte stimulating hormone and beta-endorphin immunoreactivity. A large number of neurons in the arcuate nucleus were stained after incubation of sections with antisera to e...

journal_title：Peptides

authors： Micevych PE,Elde RP

更新日期：1982-07-01 00:00:00

abstract：:Urocortin is a newly identified member of the CRF neuropeptide family. Urocortin has been found to bind with high affinity to CRF receptors. The present study investigated urocortin and CRF receptor expression in human colonic mucosa. Non-pathologic sections of adult colorectal tissues were obtained from patients with...

journal_title：Peptides

authors： Muramatsu Y,Fukushima K,Iino K,Totsune K,Takahashi K,Suzuki T,Hirasawa G,Takeyama J,Ito M,Nose M,Tashiro A,Hongo M,Oki Y,Nagura H,Sasano H

更新日期：2000-12-01 00:00:00