Abstract：
:Nociceptin/orphanin FQ (NC), the endogenous ligand of the opioid receptor-like1 (ORL1) receptor, has been reported to stimulate feeding in rats. The present article reviews the studies so far published on the effect of NC on food intake and reports new findings concerning the sensitivity of brain regions to the hyperphagic effect of NC in rats. The results obtained indicate that the hypothalamic arcuate nucleus is the most sensitive site among the brain regions so far investigated. On the basis of these findings and of the neurochemical and electrophysiological effects of NC, possible mechanisms of action and possible interactions with other neurotransmitter systems affecting feeding are discussed.
journal_name
Peptidesjournal_title
Peptidesauthors
Polidori C,de Caro G,Massi Mdoi
10.1016/s0196-9781(00)00243-6subject
Has Abstractpub_date
2000-07-01 00:00:00pages
1051-62issue
7eissn
0196-9781issn
1873-5169pii
S0196-9781(00)00243-6journal_volume
21pub_type
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