Abstract:
:Low-density lipoprotein (LDL) concentrations have been linked to altered responses to endogenous vasodilators and vasoconstrictors. We evaluated retrospectively the relationship between LDL and vasoconstrictor (endothelin-1, phenylephrine) responsiveness of the forearm vasculature in 15 elderly healthy volunteers with apolipoprotein B and LDL levels in the normal range. In contrast to phenylephrine, changes in forearm vascular resistance induced by endothelin-1 were correlated with apolipoprotein B, LDL, and total cholesterol concentrations in women but not in men. These findings might suggest that lipids may increase vascular tone through both impaired endothelial vasodilation and increased vasoconstriction to endothelin-1 at least in women.
journal_name
Peptidesjournal_title
Peptidesauthors
Romerio SC,Linder L,Flammer J,Haefeli WEdoi
10.1016/s0196-9781(00)00221-7subject
Has Abstractpub_date
2000-06-01 00:00:00pages
871-4issue
6eissn
0196-9781issn
1873-5169pii
S0196-9781(00)00221-7journal_volume
21pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::[125I]beta-endorphin bound to high affinity (Kd = 0.25 nM) receptors in the caudal dorsomedial medulla of rats with a Bmax of 97 fmol/mg protein. The relative potency for displacement of [125I]beta-endorphin binding was: beta-endorphin(1-31) > beta-endorphin(1-27) > DAMGO > naloxone > N-acetyl-beta-endorphin(1-31) > U...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00024-2
更新日期:1998-01-01 00:00:00
abstract::C-type natriuretic peptide (CNP) is expressed in the vascular endothelium. It is not known whether CNP is specifically increased in patients with idiopathic left ventricular systolic dysfunction (ILVDys) with or without overt heart failure, and whether in these patients it is related with indicators of myocardial and/...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.03.002
更新日期:2007-05-01 00:00:00
abstract::We labeled substance P (SP), neurokinin A (NKA), and [Lys0]gastrin-releasing peptide-27 (GRP) with cyanine 3.18 (cy3). Cy3-peptides purified by HPLC were fully active, determined by [Ca2+]i mobilization. Binding was specific because it was abolished by unlabeled peptides and receptor antagonists. Transfected cells yie...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)00042-i
更新日期:1995-01-01 00:00:00
abstract::Leptin has recently been discussed as a novel biomarker for the clinical outcome of critical illness. This study aims to investigate the prognostic value of leptin with regard to long-term clinical outcomes in patients with intracerebral hemorrhage. In 50 healthy controls and 92 patients with acute spontaneous basal g...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.03.010
更新日期:2013-05-01 00:00:00
abstract::The present study purifies two T. serrulatus non-disulfide-bridged peptides (NDBPs), named venom peptides 7.2 (RLRSKG) and 8 (KIWRS) and details their synthesis and biological activity, comparing to the synthetic venom peptide 7.1 (RLRSKGKK), previously identified. The synthetic replicate peptides were subjected to a ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2016.05.008
更新日期:2016-08-01 00:00:00
abstract::In the present review we reevaluated the experimental and clinical evidence that there is a local renin angiotensin system in the heart as well as the presence of a functional intracrine component which is activated during pathological conditions like heart failure and hypertension. The implications of these findings ...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2011.06.018
更新日期:2011-08-01 00:00:00
abstract::High affinity 125I-angiotensin II (Ang II) binding sites were characterized in the canine pancreas. Total binding increased with protein concentration and equilibrium was reached within 60-90 min at 22 degrees C. Specific binding was saturable and averaged 70% of total. Scatchard analysis of binding yielded a KD of 0....
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90114-i
更新日期:1992-03-01 00:00:00
abstract::Both diapause hormone (DH) and ecdysone (E) are capable of terminating pupal diapause in members of the Helicoverpa/Heliothis complex. In this study we examine how the transcript encoding prothoracicotropic hormone (PTTH), the neuropeptide that stimulates the prothoracic gland to produce E, and the transcript encoding...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.05.019
更新日期:2012-03-01 00:00:00
abstract::It is well known that neuropeptide Y (NPY) and gamma-aminobutyric acid (GABA) exert antiepileptic effects in animal models. It has recently been shown that ghrelin neurons increase the activities of GABA and NPY in the brain. Therefore it can be said that ghrelin is an antiepileptic agent. In this study we aimed to in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.04.003
更新日期:2007-06-01 00:00:00
abstract::Neuropeptide S (NPS), the endogenous ligand of NPS receptor (NPSR), regulates many biological functions, including arousal, anxiety, locomotion and food intake. NPSR mRNA is expressed in several regions of central autonomic network through which the brain controls visceromotor and other responses essential for surviva...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.03.012
更新日期:2009-07-01 00:00:00
abstract::Angiotensin (Ang)--a peptide that is part of the renin-angiotensin system-induces vasoconstriction and a subsequent increase in blood pressure; Ang peptides, especially AngII, can also act as potent pro-inflammatory mediators. Platelet-activating factor (PAF) is a potent phospholipid mediator that is implicated in man...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2015.09.002
更新日期:2015-11-01 00:00:00
abstract::One major cause for discrepancies in results from animal experimental studies is the use of different animal strains and suppliers. We have previously reported that Wistar rats from five different suppliers display profound differences in ethanol intake and behavior. One of the neurobiological processes that could be ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.04.016
更新日期:2012-07-01 00:00:00
abstract::Female Sprague-Dawley rat pups were injected SC with either ACTH(1-24) (0.5 mg/kg) or saline vehicle once daily from postnatal day 1 (day of birth) to day 7. Plasma corticosterone (CORT) levels were recorded via radioimmunoassay (RIA) on day 4 to measure adrenal response to these treatments. Hypothalamic 5-HT and DA f...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90056-m
更新日期:1993-03-01 00:00:00
abstract::Neuropeptide Y (NPY) injected into the hypothalamus stimulates feeding and affects pituitary secretion. Insulin-deficient diabetes and food deprivation markedly increase hypothalamic NPY and NPY mRNA levels, suggesting increased activity of NPYergic pathways in the hypothalamus, which could account for hyperphagia and...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90070-w
更新日期:1993-09-01 00:00:00
abstract::The incretin hormones, glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), potentiate insulin secretion and are responsible for the majority of insulin secretion that occurs after a meal. They may also, however, have a fundamental role in pancreatic beta cell development and functio...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2016.03.012
更新日期:2016-05-01 00:00:00
abstract::Radioautographic determinations of 125I-[Tyr0,D-Trp8]somatostatin-14 (125I-SRIF) binding sites were performed on frozen serial sections of the locus coeruleus (LC) of control rats and of rats subjected to either bilateral microinjections of 6 hydroxydopamine (6-OHDA) into the LC or unilateral microinjection into the a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90104-d
更新日期:1990-01-01 00:00:00
abstract::Orexin is one of the orexigenic neuropeptides in the hypothalamus. Orexin neurons in the lateral hypothalamus (LH) project into the cerebral cortex and hippocampus in which the receptors are distributed in high concentrations. Therefore, to elucidate the actions of orexin in the cerebral cortex, we examined its effect...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.05.002
更新日期:2008-09-01 00:00:00
abstract::Synthetic peptides containing a phosphorylation site for protein kinase CK2 were used to investigate their binding properties to other peptides/proteins. The aim of this work was to find an efficient procedure to search for these peptide/protein ligands. The goal was successfully achieved through screening of random p...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.12.017
更新日期:2004-02-01 00:00:00
abstract::Antimicrobial peptides (AMPs) secreted by amphibian skin represent an important innate immune defense strategy. There are more than 340 species in the family of Ranidae worldwidely, and from which nearly 100 families of AMPs comprising between 8 and 48 amino acid (aa) residues have been characterized. In current work,...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.01.014
更新日期:2012-02-01 00:00:00
abstract::Antimicrobial peptides (AMPs) are believed to be a promising class of antimicrobial agents against bacteria and fungi. To promote the clinical use of AMPs, their antimicrobial activity and susceptibility to protease degradation should be further improved. The antimicrobial peptide Jelleine-I was originally isolated fr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.11.006
更新日期:2019-02-01 00:00:00
abstract::We have previously reported that hypoxia activates corticotrophin-releasing hormone (CRH) and the expression of its type-1 receptor (CRHR1) and induces disorders of the brain-endocrine-immune network. p53 is activated by hypoxia and involved in tumorigenesis and apoptosis. Whether CRHR1 regulates p53 transactivation t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.03.023
更新日期:2013-06-01 00:00:00
abstract::Substance P (SP) is known to be involved in processes related to learning and memory, fear, anxiety and stress. SP and NK1 receptors are localized in the hippocampus, a brain structure involved in learning and memory as well as emotional processes. As there is evidence for differential functions of the ventral (VH) an...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.02.014
更新日期:2008-07-01 00:00:00
abstract::It is well known that glucoprivation induces the release of counterregulatory hormones such as glucagon, and that the response is attenuated when the stimuli are repeated. Glucoprivation also activates orexigenic neurons and induces hyperphagic responses, although it remains unclear whether these responses are attenua...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.12.009
更新日期:2011-04-01 00:00:00
abstract::Bacillus thuringiensis Cry toxins recognizes their target cells in part by the binding to glycosyl-phosphatidyl-inositol (GPI) anchored proteins such as aminopeptidase-N (APN) or alkaline phosphatases (ALP). Treatment of Tenebrio molitor brush border membrane vesicles (BBMV) with phospholipase C that cleaves out GPI-a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.05.019
更新日期:2013-03-01 00:00:00
abstract::Glucagon-like peptide-1 (GLP-1) is a proglucagon-derived hormone with cellular protective actions. We hypothesized that GLP-1 would protect the endothelium from injury during inflammation. Our aims were to determine the: (1) effect of GLP-1 on basal microvascular permeability, (2) effect of GLP-1 on increased microvas...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.06.019
更新日期:2009-09-01 00:00:00
abstract::There is a well-documented association between cyclic changes to food intake and the changing ovarian hormone levels of the reproductive cycle in female mammals. Limited research on appetite-controlling gastrointestinal peptides has taken place in females, simply because regular reproductive changes in steroid hormone...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.02.010
更新日期:2017-04-01 00:00:00
abstract::The effects of proadrenomedullin N-terminal 20 peptide (PAMP) and adrenotensin (ADT) on adrenomedullin (ADM)-induced vasodilation were investigated in aortic rings from rat. ADM (10(-9) to 10(-7)M) relaxed the aorta preconstricted with phenylephrine in a concentration-dependent manner. Denudation of endothelium or pre...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(03)00109-8
更新日期:2003-04-01 00:00:00
abstract::Two cDNAs, size 969 bp and 1146 bp respectively, encoding goldfish gamma-preprotachykinin (gamma-PPT) were identified. Both cDNAs contain the same 345 bp open reading frame. The deduced 114-amino acid gamma-PPT contains the sequence of substance P, carassin and neurokinin A. sequence analysis of the two cDNA 5'-untran...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00013-2
更新日期:1997-01-01 00:00:00
abstract::The biological activities of alpha-MSH des-acetyl MSH, gamma-MSH and LPH37-58 were compared using the Anolis rate method of bioassay. Dose-response data showed LPH37-58 to be equipotent with alpha-MSH, but des-acetyl MSH and gamma-MSH were found to be much less active. The effect of LPH37-58 was additive to that of al...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90134-6
更新日期:1982-01-01 00:00:00
abstract::Despite the high impact of the antimicrobial peptide hepcidin in iron homeostasis, the regulation of this hormone is still not completely understood. Studies concerning hepcidin regulation are performed at the mRNA level. For the first time we analyzed the regulation of hepcidin not only at mRNA, but also at protein l...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.01.016
更新日期:2007-05-01 00:00:00