Abstract：
:Female Sprague-Dawley rat pups were injected SC with either ACTH(1-24) (0.5 mg/kg) or saline vehicle once daily from postnatal day 1 (day of birth) to day 7. Plasma corticosterone (CORT) levels were recorded via radioimmunoassay (RIA) on day 4 to measure adrenal response to these treatments. Hypothalamic 5-HT and DA fiber densities were assessed using high-affinity specific 3H-5-HT and 3H-DA uptake at days 7, 25, and at adulthood (80-90 days). Animals were checked daily for vaginal opening (starting on day 30) as a sign of sexual maturation and later tested for sexual behavior as virgins (60-70 days of age). Plasma estradiol and progesterone levels were measured via RIA. Plasma CORT levels were greatly increased among ACTH-treated animals during the treatment period. The 5-HT uptake was significantly increased in ACTH-treated animals at day 7 (p < 0.01) and at adulthood (p < 0.02) compared to controls. The DA uptake was significantly higher among ACTH-treated animals at day 7 (p < 0.01). The sexual maturation of ACTH-treated animals was delayed when compared to control animals (p < 0.01). The ACTH-treated animals displayed slight deficits in female sexual behavior compared to control animals (p < 0.05). No significant changes in plasma sex steroid levels were found. Based on this study, we suggest that monoamine innervation into the developing female hypothalamus is susceptible to early postnatal manipulation with ACTH and CORT, and that the resulting changes in these monoamine fiber densities may be responsible for the observed deficits in reproductive maturation and behavior.
journal_name
Peptidesjournal_title
Peptidesauthors
Alves SE,Akbari HM,Azmitia EC,Strand FLdoi
10.1016/0196-9781(93)90056-msubject
Has Abstractpub_date
1993-03-01 00:00:00pages
379-84issue
2eissn
0196-9781issn
1873-5169pii
0196-9781(93)90056-Mjournal_volume
14pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:Osmotic stress stimulates the release of the avian hypothalamic neuropeptide arginine vasotocin (AVT) into the peripheral circulation. We conducted the present study to investigate the effects of salt-loading on AVT secretion and AVT gene expression in specific hypothalamic nuclei in chickens. White Leghorn chickens w...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00190-3
更新日期：1997-01-01 00:00:00
abstract：:C-type natriuretic peptide (CNP) is assuming increasing importance in cardiovascular disease, and in adults its plasma levels are related to clinical and functional disease severity. Data are scarce regarding the reference values for CNP in infancy. Aim of this study was to assess the reference intervals for CNP in hu...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.11.005
更新日期：2012-01-01 00:00:00
abstract：:CRF system, structural conservation, has an association with feeding regulation in mammals. However, mammals and fish have different physiological mechanisms, the potential role of CRF system for feeding regulation in teleost fish are most unknown. To better explore possible feeding mechanisms of CRF system in Acipens...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2020.170309
更新日期：2020-06-01 00:00:00
abstract：:Cholecystokinin octapeptides (CCK8s) have been purified from methanol extracts of two brains from each of two Australian marsupials, Tammar Wallaby and Eastern Quoll, containing 3 nmol and 2 nmol of the peptides, respectively. Immunoreactive CCK was concentrated on QMA SepPak cartridges and purified by two successive ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(88)90280-x
更新日期：1988-03-01 00:00:00
abstract：:As a class of peptides with 10 cysteine residues (-C-CC-C-CC-C-C-C-C-), D-superfamily conotoxins (D-conotoxins) can specifically act on nicotinic acetylcholine receptors (nAChRs). According to the conserved signal peptides of D-conotoxins, seven D-conotoxin precursor sequences with a previously undescribed Cys arrange...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2017.06.008
更新日期：2017-08-01 00:00:00
abstract：:In an immunohistochemical study, a specific antiserum raised against [D-Ala2]deltorphin-I (DADTI), a highly selective ligand for delta opioid receptors, was used to demonstrate immunoreactive structures in the rat retina. [D-Ala2]Deltorphin-I immunoreactivity occurred in a subpopulation of the retinal amacrine cells s...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90169-4
更新日期：1994-01-01 00:00:00
abstract：:The role of neuropeptides in cardiomyopathy-associated heart failure has been garnering more attention. Several neuropeptides--Neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), calcitonin gene related peptide (CGRP), substance P (SP) and their receptors have been studied in the various types of cardiomyopathi...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2014.08.004
更新日期：2014-11-01 00:00:00
abstract：:Ablation of the frontal neocortex markedly enhanced the antinociceptive and cataleptic actions of beta-endorphin injected into the lateral ventricle of rat brain. This enhanced response was not affected by simultaneous administration of cholecystokinin octapeptide (CCK-8). In sham-operated rats, however, CCK-8 suppres...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90046-4
更新日期：1985-03-01 00:00:00
abstract：:VIP and related fragments were prepared by the solid-phase method. The peptides were assembled on a benzhydrylamine resin and couplings of the Boc-amino acids were carried out by the symmetrical anhydride method. Cleavage was achieved by treatment with liquid HF and purification was accomplished by successive steps of...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90202-x
更新日期：1984-03-01 00:00:00
abstract：:The binding and internalization of a cytotoxic analogue of luteinizing hormone-releasing hormone (LH-RH), T-98 (agonist [D-Lys6]LH-RH linked to glutaryl-2-(hydroxymethyl)anthraquinone), by rat anterior pituitary cells was investigated. Analogue T-98 was bound to pituitary membrane binding sites for LH-RH with a high a...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90024-8
更新日期：1994-01-01 00:00:00
abstract：:ZP120 is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) ligand. In previous studies, the effects of ZP120 were found to be sensitive to J-113397 in mouse tissues while resistant to UFP-101 in rat tissues. The aim of this study was to further investigate the ZP120 pharmacological profile using mouse and rat pr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.10.001
更新日期：2009-02-01 00:00:00
abstract：:Endothelin-1 may contribute to bronchial smooth muscle constriction and airway remodelling in asthma, where bronchial epithelial cells represent an important source of this peptide. We report here that asthmatic bronchial epithelial cells exposed to allergens in vitro induce the differentiation of airway fibroblasts i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00194-0
更新日期：1997-01-01 00:00:00
abstract：:Galanin has been shown to be present in substantial quantities in the human and rat genitourinary tract by radioimmunoassay and immunocytochemistry. The highest concentrations measured by radioimmunoassay were found in the human vas deferens, corpus cavernosum and spongiosum and in the vagina and cervix. In man gel ch...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90052-5
更新日期：1986-01-01 00:00:00
abstract：:The effects of acute and subchronic administration of chlordiazepoxide (CDZ) on [3H][3-methyl-histidyl2]thyrotropin-releasing hormone binding to thyrotropin-releasing hormone (TRH) receptors in membrane preparations from various regions of rat brain were examined. Acute administration of CDZ (50 mg/kg x 3 within 24 h)...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(91)90188-u
更新日期：1991-01-01 00:00:00
abstract：:High plasma copeptin level has been associated with one-month mortality after traumatic brain injury. However, not much is known regarding its relation with long-term outcome. Thus, we investigated the ability of copeptin to predict 1-year outcome in patients with traumatic brain injury. One hundred and six healthy co...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.11.017
更新日期：2012-01-01 00:00:00
abstract：:The hypotensive effect of proadrenomedullin N-terminal 20 peptide (PAMP) was examined in conscious pregnant (8, 14, and 20 days of pregnancy) and nonpregnant rats. Intravenous administration of PAMP (3-60 nmol/kg) produced a dose-dependent depressor response in both pregnant and nonpregnant rats. However, the maximum ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00165-5
更新日期：1999-12-01 00:00:00
abstract：:We performed the first comprehensive peptidomic analysis of neurohormones from hemipteran insects by analyzing the neuropeptides of two major neurohemal organs, namely the corpora cardiaca and abdominal perisympathetic organs. For the experiments we selected four related species of polyphagous stinkbugs (Pentatomidae)...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.08.034
更新日期：2008-02-01 00:00:00
abstract：:We produced and characterized three anti-C-flanking peptides of neuropeptide Y (CPON) monoclonal antibodies. The Ka for these antibodies ranged from 0.4 to 0.8 x 10(8) l/mol with an IC50 for CPON(1-30) at about 20 nM as determined by ELISA. All these antibodies are IgG1 and recognize the 16-30 part of CPON. These anti...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90112-0
更新日期：1994-01-01 00:00:00
abstract：:The hypocretins (1 and 2) have emerged as key regulators of sleep and wakefulness. We developed a high-throughput enzyme immunoassay (EIA) to measure total brain hypocretin levels from large numbers of mice. Hypocretin levels were not altered by circadian time or age. However, significant differences in one or both hy...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(02)00251-6
更新日期：2002-12-01 00:00:00
abstract：:Pacifastin-like protease inhibitors belong to a recent classified protease inhibitor family and they are the smallest protease inhibitors described in animals. In this work, we purified and characterized, for the first time, two neutrophil elastase inhibitors belonging to the pacifastin family from the blood sucking i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.03.033
更新日期：2010-07-01 00:00:00
abstract：:Low-density lipoprotein (LDL) concentrations have been linked to altered responses to endogenous vasodilators and vasoconstrictors. We evaluated retrospectively the relationship between LDL and vasoconstrictor (endothelin-1, phenylephrine) responsiveness of the forearm vasculature in 15 elderly healthy volunteers with...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00221-7
更新日期：2000-06-01 00:00:00
abstract：:Intraperitoneal (i.p.) administration of the synthetic agonist of the glucagon like peptide-1 (GLP-1) receptor exenatide reduces food intake. Here, we evaluated possible peripheral pathways for this reduction. Exenatide (0.5 μg/kg, i.p.) was given to three, overnight food-deprived, groups of rats: total subdiaphragmat...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.12.009
更新日期：2012-02-01 00:00:00
abstract：:Recent refinements in methodology now permit the study of endogenous peptide hormones in their individual target cells. The investigations reported here deal with the question of whether endogenous ACTH can be detected in its target cells in the highly active adrenal gland of the normally lactating rat. This question ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(80)90062-5
更新日期：1980-10-01 00:00:00
abstract：:Kisspeptins, a family of peptide products derived from the KiSS-1 gene, activate their cognate receptor GPR54 in various target tissues to exert disparate functions, including inhibition of tumor metastasis and control of reproductive function. In contrast to the plethora of studies that have analyzed in recent years ...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2008.07.025
更新日期：2009-01-01 00:00:00
abstract：:Prolactin (PRL) is known to exert neuroprotective effects against excitotoxic damage in the hippocampus of female rats, both in vitro and in vivo. It is still unknown whether this effect can be seen in the male hippocampus and intracellular signaling mediating such action. To assess this, adult male CD-1 mice were sub...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2020.170425
更新日期：2021-01-01 00:00:00
abstract：:As a novel vasoactive peptide, plasma coupling factor 6 (CF6) was shown to be elevated in patients with diabetes mellitus, yet the mechanism involved is unknown. We studied CF6 protein release and its potential mechanism in human umbilical vein endothelial cells (HUVECs) incubated with high glucose levels. High glucos...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.11.006
更新日期：2007-03-01 00:00:00
abstract：:Our previous findings that the degree of endotoxin-induced hypotension in the dog is inversely related to ambient temperature (19 degrees through 30 degrees C) and that only increased doses of naloxone are effective at 19 degrees C suggested that opioid activity is also influenced by ambient temperature, increasing in...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90007-5
更新日期：1985-01-01 00:00:00
abstract：:The puromycin-sensitive aminopeptidase (ApPS) is a zinc metallopeptidase involved in the degradation of neuropeptides. Putative catalytic residues of the enzyme, Cys146, Glu338, and Lys396 were mutated, and the resultant mutant enzymes characterized. ApPS C146S exhibited normal catalytic activity, ApPS E338A exhibited...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2003.07.012
更新日期：2003-09-01 00:00:00
abstract：:Host-defense peptides secreted by epithelial cells exhibit cytotoxic and immunoregulatory effects in order to protect the organism against invading microorganisms. Antimicrobial peptides derived from frog skin display both immunostimulatory and immunosuppressive actions as demonstrated by in vitro cytokine production ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2015.03.028
更新日期：2015-09-01 00:00:00
abstract：:We sought to establish Endothelin (ET-3) role in the central regulation of bile secretion in the rat. The intracerebroventricular (icv) injection of ET-3 evoked a cholestatic or a choleretic effect depending on the administered dose. Lower doses increased bile flow and bicarbonate excretion, whereas higher doses decre...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.02.003
更新日期：2005-07-01 00:00:00
