Abstract：
:We produced and characterized three anti-C-flanking peptides of neuropeptide Y (CPON) monoclonal antibodies. The Ka for these antibodies ranged from 0.4 to 0.8 x 10(8) l/mol with an IC50 for CPON(1-30) at about 20 nM as determined by ELISA. All these antibodies are IgG1 and recognize the 16-30 part of CPON. These antibodies and a specific anti-NPY monoclonal antibody were used to study the localization of CPON and NPY in the human kidney. The avidin-biotin technique was employed. NPY and CPON immunoreactivities were present in large amount in the renal tubules of the human kidney but not in the glomeruli. No labeling was found within the renal arterioles and veins, but some immunoreactivity was evidenced in the perivascular area. Because no specific receptor for CPON has been described to date, the presence of this peptide in the tubules may be due to a tubular reabsorption or perhaps to a local synthesis of pro-NPY.
journal_name
Peptidesjournal_title
Peptidesauthors
Grouzmann E,Alvarez-Bolado G,Meyer C,Osterheld MC,Burnier M,Brunner HR,Waeber Bdoi
10.1016/0196-9781(94)90112-0subject
Has Abstractpub_date
1994-01-01 00:00:00pages
1377-82issue
8eissn
0196-9781issn
1873-5169pii
0196-9781(94)90112-0journal_volume
15pub_type
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