Abstract:
:Prolactin releasing peptide (PrRP) was originally reported to act in the anterior lobe of the pituitary gland to stimulate prolactin (PRL) release; however, numerous other pharmacologic actions of PrRP have been described. In the central nervous system PrRP inhibits food intake, stimulates sympathetic tone, and activates stress hormone secretion. Here, we confirm the presence of immunoreactive PrRP in a pheochromocytoma-derived cell line (PC-12) and the ability of exogenous PrRP to stimulate adenylyl cyclase activity in these cultures. Our novel findings are that PrRP stimulated PC-12 cell growth. Furthermore, a role for endogenous PrRP in PC-12 cell growth is suggested by our observations that antisense oligonucleotides and small interfering RNA molecules, which decrease peptide content in these cells, also decrease thymidine incorporation, suggesting an autocrine action of the peptide.
journal_name
Peptidesjournal_title
Peptidesauthors
Samson WK,Taylor MMdoi
10.1016/j.peptides.2006.01.008subject
Has Abstractpub_date
2006-05-01 00:00:00pages
1099-103issue
5eissn
0196-9781issn
1873-5169pii
S0196-9781(06)00054-4journal_volume
27pub_type
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