Abstract：
:A functional study has been performed to characterise the Y receptors responsible for NPY, PYY and PP-stimulated responses in mouse colonic mucosal preparations. Electrogenic ion secretion was stimulated with VIP following which NPY, PYY and PP analogues were, to varying degrees, inhibitory. PYY(3-36), hPP, Gln(23)hPP and rPP were effective but less potent than full length PYY, NPY or their Pro(34)-substituted analogues, while the Y(5) agonist Ala(31), Aib(32)hNPY was the least active peptide tested. The Y(1) antagonists, BIBP3226 and BIBO3304 virtually abolished Pro(34)PYY and PYY responses while PYY(3-36) responses were selectively inhibited by the Y(2) antagonist, BIIE0246. A combination of BIBO3304 and BIIE0246 also partially attenuated hPP responses, leaving residual effects that were most probably Y(4)-mediated. Thus we conclude that Y(1), Y(2) and Y(4) receptors attenuate ion secretion in mouse colon.
journal_name
Peptidesjournal_title
Peptidesauthors
Cox HM,Pollock EL,Tough IR,Herzog Hdoi
10.1016/s0196-9781(01)00355-2subject
Has Abstractpub_date
2001-03-01 00:00:00pages
445-52issue
3eissn
0196-9781issn
1873-5169pii
S0196-9781(01)00355-2journal_volume
22pub_type
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