Abstract:
:The effect of synthetic human calcitonin gene-related peptide (hCGRP) on the isolated and electrically driven left atria of rats were investigated. The peptide at concentrations of 3 X 10(-9)-3 X 10(-7) M produced positive inotropic effects on the left atria in a dose-dependent manner. Verapamil (10(-5) M) and adenosine (10(-4) M) reduced the positive inotropic effect of hCGRP at concentrations of 3 X 10(-9) and 3 X 10(-8) M, but not at that of 3 X 10(-7) M. Ouabain (5 X 10(-5) M) inhibited the effect of hCGRP in concentrations of 3 X 10(-7) and 3 X 10(-8) M, but not in that of 3 X 10(-9) M. Simultaneous pretreatment with verapamil (10(-5) M) and ouabain (5 X 10(-5) M) suppressed the positive inotropy by hCGRP at all concentrations tested. On the other hand, tetrodotoxin (10(-6) M) potentiated only the positive inotropic effect of 3 X 10(-7) M hCGRP. Metoprolol (10(-7) M) and theophilline (10(-3) M) did not affect the inotropic effect of hCGRP. These results suggest that the positive inotropic effect of hCGRP is not mediated by beta-adrenoceptors but by two distinct mechanisms of action, which was inhibited by verapamil but not by ouabain (facilitation of Ca++ influx in lower concentrations of hCGRP) and which was blocked by ouabain but not by verapamil and potentiated by tetrodotoxin (inhibition of Na+/Ca++ exchange mechanism at higher concentrations of hCGRP).
journal_name
Peptidesjournal_title
Peptidesauthors
Satoh M,Oku R,Maeda A,Fujii N,Otaka A,Funakoshi S,Yajima H,Takagi Hdoi
10.1016/0196-9781(86)90038-0subject
Has Abstractpub_date
1986-07-01 00:00:00pages
631-5issue
4eissn
0196-9781issn
1873-5169pii
0196-9781(86)90038-0journal_volume
7pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Acute treatment of rats with haloperidol results in a rapid and transient increase in striatal c-fos mRNA and Fos immunoreactivity. The induction of immediate early genes by haloperidol may be involved in the development of extrapyramidal side effects. L-Prolyl-L-leucyl-glycinamide (PLG, or MIF-1) has been observed to...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00194-1
更新日期:2000-02-01 00:00:00
abstract::Injection of capsaicin into the hindpaw has been employed as a model of chemogenic nociception in mice. Intraplantar injection of nociceptin (30-240 pmol) produced a significant and dose-dependent antinociceptive activity in the capsaicin test. The nociceptin N-terminal fragments, (1-11) and (1-13), were also active w...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.05.022
更新日期:2005-12-01 00:00:00
abstract::Neuropeptide FF (NPFF) has certain antiopiate actions and may play a role in opiate tolerance and dependence. Third ventricle injection of 10 micrograms NPFF induces a quasimorphine abstinence syndrome in opiate-naive rats. Nitric oxide synthesis may also contribute to opiate tolerance and dependence. The present stud...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00035-6
更新日期:1996-01-01 00:00:00
abstract::Early-life stress is a key predisposing factor to the development of functional gastrointestinal (GI) disorders. Thus, changes in stress-related molecular substrates which influence colonic function may be important in understanding the pathophysiology of such disorders. Activation of peripheral corticotropin-releasin...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.01.004
更新日期:2010-04-01 00:00:00
abstract::Caudodorsal cell hormone-I (CDCH-I), a 36 amino acid peptide synthesized by the caudodorsal cells (CDCs), is one of the major neuropeptides present in the cerebral ganglia of the freshwater snail, Lymnaea stagnalis. This peptide induces ovulation and egg-mass formation, and, in addition, acts on neuronal circuits invo...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90099-o
更新日期:1992-03-01 00:00:00
abstract::In the conscious dog migrating and nonmigrating colonic motor complexes (CMC) were recorded by means of chronically implanted strain gauge force transducers. Intravenous injection of a synthetic enkephalin analogue immediately induced a premature CMC at all three recording sites of the colon. Naloxone inhibited the en...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90155-6
更新日期:1988-05-01 00:00:00
abstract::Suppression subtractive hybridization comparing brains from diapausing and nondiapausing pupae of the flesh fly, Sarcophaga crassipalpis, suggested that the gene encoding neuropeptide-like precursor 4 (Nplp4) was uniquely expressed during diapause. We have sequenced the full-length cDNA encoding Nplp4 and used Norther...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.10.008
更新日期:2009-03-01 00:00:00
abstract::A short neuropeptide F (sNPF) precursor and a sNPF receptor (sNPFR) were characterized for the mosquito, Anopheles gambiae. The sNPFR was expressed in CHO-K1 cells, and it exhibited high affinity binding, IC(50) approximately 3-5 nM, for specific sNPFs. sNPF1 potently inhibited forskolin-stimulated cAMP production by ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.09.019
更新日期:2007-01-01 00:00:00
abstract::We tested the endogenous tripeptide TRH (thyrotropin releasing hormone) ability to bind to MC (melanocortin) receptor subtypes. We discovered that TRH binds to the human MCI receptor expressed in COS cells and to murine B16 melanoma cells with 5790+/-1010 nM and 6370+/-1260 nM Ki's, respectively. TRH did not bind to t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00168-5
更新日期:1999-01-01 00:00:00
abstract::Parathyroid hormone (PTH) has been shown to have actions within the brain, suggesting the presence of central PTH receptors. This possibility was examined by determining the binding of 125I-labeled [Nle8,18,Tyr34]bovine PTH to the plasma membranes of rat and rabbit brains. Specific binding of the tracer to membranes o...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90174-f
更新日期:1993-11-01 00:00:00
abstract::Sympathetic neurotransmitter neuropeptide Y (NPY) is associated with vascular remodelling, neointimal hyperplasia and atherosclerosis in experimental animal models and clinical studies. In order to study the role of sympathetic nerve-produced NPY in vascular diseases, transgenic mouse model overexpressing NPY in centr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.12.009
更新日期:2009-04-01 00:00:00
abstract::Peptides have the potential to be potent pharmaceutical agents for the treatment of many central nervous system derived maladies. Unfortunately peptides are generally water-soluble compounds that will not enter the central nervous system, via passive diffusion, due to the existence of the blood-brain barrier. Peptides...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(01)00537-x
更新日期:2001-12-01 00:00:00
abstract::We have evaluated a new immunoradiometric assay (IRMA) for calcitonin (CT) (Medgenix, Belgium). The detection limit of immunoreactive CT (IR-CT) was 2.8 pg/ml, and plasma levels of IR-CT of 134 healthy adults (dynamic range, 2.8-1000 pg/ml) were < 19 pg/ml (median 4.1 pg/ml). Both basal and pentagastrin-stimulated IR-...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)00177-4
更新日期:1995-01-01 00:00:00
abstract::Lipocalin-2 (LCN-2), a peptide with diverse expression pattern, has been identified as a biomarker of various diseases as well as a factor contributing to inflammatory responses associated with excess adiposity and ensuing metabolic disorders. Although the inter-relationship between LCN-2 and excess adiposity is incre...
journal_title:Peptides
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.peptides.2019.170117
更新日期:2019-09-01 00:00:00
abstract::Previous studies have shown that the nervous system and other tissues of molluscs contain a number of peptides that potently excite molluscan hearts. Two such peptides, termed small cardioactive peptides A and B (SCPA and SCPB) are present in large quantities in the nervous system of Aplysia. These peptides are widely...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90184-7
更新日期:1987-01-01 00:00:00
abstract::Urocortin is a newly identified member of the CRF neuropeptide family. Urocortin has been found to bind with high affinity to CRF receptors. The present study investigated urocortin and CRF receptor expression in human colonic mucosa. Non-pathologic sections of adult colorectal tissues were obtained from patients with...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00335-1
更新日期:2000-12-01 00:00:00
abstract::Neuropeptide Y (NPY) is one of the most potent stimulants of food intake in mammals, but very little is known about NPY actions in fish. The present study investigated the role of NPY in food intake in the rainbow trout (Oncorhynchus mykiss). Food intake was monitored at different times after intracerebroventricular a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.09.014
更新日期:2006-04-01 00:00:00
abstract::Defensins are essentially ancient natural antibiotics with potent activity extending from lower organisms to humans. They can inhibit the growth or virulence of micro-organisms directly or indirectly enhance the host's immune system. The successful prediction of defensin peptides will provide very useful information a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.06.032
更新日期:2009-10-01 00:00:00
abstract::While neuropeptides of the allatostatin family inhibit in vitro production of juvenile hormone, which modulates aspects of development and reproduction in the cockroach, Diploptera punctata, they are susceptible to inactivation by peptidases in the hemolymph, gut, and bound to internal tissues. Patterns of peptidase c...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00149-1
更新日期:1999-01-01 00:00:00
abstract::A retrograde facilitation has been demonstrated in the one trial step-down inhibitory avoidance of melanin-concentrating hormone (MCH), when it was infused into rat hippocampal formation. Considering the high density of specific binding sites for the MCH peptide on the hippocampus and the participation of this structu...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00591-5
更新日期:2002-01-01 00:00:00
abstract::The neuroendocrine and behavioral effects of Tyr-D-Ala-Gly-Phe-D-Nle-Arg-Phe (DADN), a more stable derivative of the endogenous opiate Met-enkephalin related peptide Met(5)-enkephalin-Arg(6)-Phe(7) were investigated in mice. The behavioral experiments consisted of monitoring the horizontal (square crossing) and vertic...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.05.029
更新日期:2011-08-01 00:00:00
abstract::Melanin-concentrating hormone (MCH) is a hypothalamic peptide that plays a critical role in the regulation of food intake and energy metabolism. In this study, we investigated the potential role of dense hippocampal MCH innervation in the spatially oriented food-seeking component of feeding behavior. Rats were trained...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2015.12.007
更新日期:2016-02-01 00:00:00
abstract::Phoenixin, a recently discovered 20-amino acid peptide was implicated in reproduction. However, the expression in food intake-regulatory nuclei such as the paraventricular nucleus, the arcuate nucleus and the nucleus of the solitary tract suggests an implication of phoenixin in food intake regulation. Therefore, we in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.08.004
更新日期:2017-10-01 00:00:00
abstract::Two cDNAs, size 969 bp and 1146 bp respectively, encoding goldfish gamma-preprotachykinin (gamma-PPT) were identified. Both cDNAs contain the same 345 bp open reading frame. The deduced 114-amino acid gamma-PPT contains the sequence of substance P, carassin and neurokinin A. sequence analysis of the two cDNA 5'-untran...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00013-2
更新日期:1997-01-01 00:00:00
abstract::The location of the cells giving rise to the tachykinergic innervation of the rat arcuate nucleus was studied by combining immunohistochemistry and retrograde axonal transport of a protein-gold complex (WGA-ApoHRP-gold). Small volumes (20 nl) of this marker were injected into the arcuate nucleus of the rat. Twenty-fou...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90042-f
更新日期:1993-03-01 00:00:00
abstract::Studies on the in vitro interaction of beta-endorphin with different biomembrane preparations, measured in terms of Ca2+ induced chlorotetracycline (CTC) fluorescence alterations indicate that beta-endorphin causes release of calcium ion from both synaptosomal and erythrocyte membrane stores but not from rat brain mit...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90131-6
更新日期:1983-05-01 00:00:00
abstract::There is growing evidence of the antimicrobial properties of histones and histone-derived peptides; however, most of them are specific to lysine (Lys)-rich histones (H1, H2A, and H2B). In the present study, we focused on arginine (Arg)-rich histones (H3 and H4) and investigated their antimicrobial properties in compar...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.09.005
更新日期:2011-10-01 00:00:00
abstract::This paper reviews aspects of our research, focusing on the role of the melanocortin system in the central regulation of feeding and energy balance, which was begun in 1997. It describes data from successive physiological studies, concerning the identity of the appetite-regulating melanocortin receptor, melanocortin-4...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2005.01.030
更新日期:2006-02-01 00:00:00
abstract::PACAP-27 and PACAP-38 are the exclusive physiological ligands for the mammalian PAC1 receptor. The role of C-terminal amidation of these ligands at that receptor was examined in neuroendocrine cells expressing the PAC1 receptor endogenously and in non-neuroendocrine cells in which the human and rat PAC1 receptors were...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2016.03.003
更新日期:2016-05-01 00:00:00
abstract::Quantitative receptor autoradiography was used to examine the binding of [125I]-human CGRP in the dorsal horn of the L4 spinal segment of rats with a chronic constriction injury (CCI) of the sciatic nerve or unilateral dorsal rhizotomies of spinal segments L1-L6. At the times selected for study, we found no change in ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90221-a
更新日期:1991-11-01 00:00:00