Abstract:
:Neuropeptide FF (NPFF) has certain antiopiate actions and may play a role in opiate tolerance and dependence. Third ventricle injection of 10 micrograms NPFF induces a quasimorphine abstinence syndrome in opiate-naive rats. Nitric oxide synthesis may also contribute to opiate tolerance and dependence. The present study tests the hypothesis that NPFF acts through stimulation of nitric oxide synthase (NOS). Third ventricular injection of 10 micrograms NPFF precipitated an average of 46 abstinence-like signs during a 20-min observation. Pretreatment (30 min earlier) with 7.5 or 15 mg/kg s.c. of the NOS inhibitor nitro-L-arginine (L-NNA) resulted in a significant and dose-dependent alleviation of NPFF-induced abstinence-like signs. The anti-NPFF activity of 15 mg/kg L-NNA was blocked by 750 mg/kg L-arginine, but not by the same amount of D-arginine, indicating that L-NNA attenuates NPFF activity through a stereospecific inhibition of NOS.
journal_name
Peptidesjournal_title
Peptidesauthors
Malin DH,Lake JR,Jones JA,Morel J,Moon WD,Corbit BP,Smith DA,Claunch AE,Kacher D,Stevens PA,Webb SLdoi
10.1016/0196-9781(96)00035-6subject
Has Abstractpub_date
1996-01-01 00:00:00pages
615-8issue
4eissn
0196-9781issn
1873-5169pii
0196978196000356journal_volume
17pub_type
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