Abstract：
:The localization of CCK8-, bombesin- and VIP-like immunoreactivities in the myenteric plexus of the guinea pig small intestine has been studied by radioimmunoassay of extracts of longitudinal muscle strips obtained with and without adherent myenteric plexus; concentrations were compared with those in other regions of the gut. In innervated strips of longitudinal muscle of ileum there was approximately 14 pmol/g CCK8-, 32 pmol/g bombesin- and 135 pmol/g VIP-like immunoreactivity; concentrations were reduced by over 70% in denervated strips. Gel filtration and ion exchange chromatography indicated that over 80% of CCK immunoreactivity was due to CCK8; no evidence was found of significant amounts of smaller COOH-terminal fragments. Bombesin immunoreactivity occurred in two forms, the major one resembling the amphibian tetradecapeptide in its elution from gel filtration columns. Immunoreactive VIP differed markedly from porcine VIP in immunochemical and chromatographic properties; the data suggest that guinea pig VIP is less basic than porcine VIP and that the two peptides differ in structure in their NH2-terminal regions. Some functional implications of these findings are discussed.
journal_name
Peptidesjournal_title
Peptidesauthors
Hutchison JB,Dimaline R,Dockray GJdoi
10.1016/s0196-9781(81)80007-1subject
Has Abstractpub_date
1981-04-01 00:00:00pages
23-30issue
1eissn
0196-9781issn
1873-5169pii
S0196-9781(81)80007-1journal_volume
2pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:Peptides of the adipokinetic hormone (AKH)/red pigment-concentrating hormone (RPCH) family were isolated and sequenced from the retrocerebral corpora cardiaca of four kissing bugs which are all vectors of the protozoan Trypanosoma cruzi responsible for Chagas' disease. The sequence of three novel AKHs were deduced fro...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.09.032
更新日期：2013-03-01 00:00:00
abstract：:The first member of the periviscerokinin peptide family in Locusta migratoria was identified by post-source decay fragmentation on a MALDI-TOF mass spectrometer using a single neurohemal organ only. The primary sequence of this decapeptide, code-named Lom-PVK, is Ala-Ala-Gly-Leu-Phe-Gln-Phe-Pro-Arg-Val-NH(2). Unlike t...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(01)00669-6
更新日期：2002-04-01 00:00:00
abstract：:The peptidome of the central nervous system of adult cabbage root fly, Delia radicum (L) was investigated using matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS). Over twenty neuropeptides were identified from three different tissue sources, the combined brain/suboesophageal g...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.08.028
更新日期：2011-03-01 00:00:00
abstract：:The monoclonal antibody 2F5 recognizing the neutralizing epitope ELDKWA on the C-domain could neutralize 90% of the investigated HIV-1 isolates. Low levels of ELDKWA-epitope-specific antibodies were observed in HIV-1-infected individuals. To induce high levels of antibodies to ELDKW-epitope, C-domain peptide (P2) was ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00179-0
更新日期：2000-04-01 00:00:00
abstract：:The occurrence of neuropeptides in the frontal ganglia of larvae of the tobacco hawkmoth, Manduca sexta, the tomato moth, Lacanobia oleracea and the cotton leafworm, Spodoptera littoralis was investigated using reversed-phase high performance liquid chromatography (RP-HPLC), matrix-assisted laser desorption time of fl...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.10.011
更新日期：2005-01-01 00:00:00
abstract：:We screened nearly 1000 synthetic peptides and found that JAL-AK22 (KYEGHWYPEKPYKGSGFRCIHI), which is derived from the BoxA domain in the Tob1 protein, activates both unfolded and folded proMMP-7. Interestingly, the smaller derivative of JAL-AK22, termed JAL-TA9 (YKGSGFRMI) possessed auto-proteolytic activity and clea...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2019.03.005
更新日期：2019-06-01 00:00:00
abstract：:Injection of capsaicin into the hindpaw has been employed as a model of chemogenic nociception in mice. Intraplantar injection of nociceptin (30-240 pmol) produced a significant and dose-dependent antinociceptive activity in the capsaicin test. The nociceptin N-terminal fragments, (1-11) and (1-13), were also active w...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.05.022
更新日期：2005-12-01 00:00:00
abstract：:Peptides of the short neuropeptide F (sNPF) family have been shown to modulate feeding behavior in a wide variety of insect species. While these peptides stimulate feeding and food-searching behavior in Drosophila melanogaster and Apis mellifera, an opposite effect has recently been demonstrated in the desert locust, ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.09.018
更新日期：2014-03-01 00:00:00
abstract：:The interindividual variability of the hydrolysis of leucine enkephalin, and of the formation of its hydrolysis by-products has been studied in human plasma. In agreement with known data, the data obtained indicate that Leu-enkephalin is degraded by several enzymes, belonging to three classes: aminopeptidases, dipepti...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00129-0
更新日期：1997-01-01 00:00:00
abstract：:Neural input to distinct and separate populations of CRF-immunoreactive (ir) neurons in rat forebrain was investigated. The relationship of opiocortin and/or catecholamine fibers to different groups of CRF-containing neurons was elucidated using single and dual labeling immunocytochemical procedures. Antibodies to CRF...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(89)90005-3
更新日期：1989-11-01 00:00:00
abstract：:Oxyntomodulin (OXM), a 37-amino acid glucagon-containing peptide produced mainly in intestine and endocrine pancreas, is present in rat plasma and inhibits pentagastrin-stimulated gastric acid secretion in both the anesthetized and the conscious rat. In order to investigate the modifications in acid and water secretio...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90196-8
更新日期：1986-01-01 00:00:00
abstract：:The decapeptide from the frog Hyla caerulea, caerulein (caerulein diethylammonium hydrate, ceruletide, CER) is chemically closely related to the C-terminal octapeptide of cholecystokinin (CCK-8). Like CCK-8, CER and some of its analogues produce many behavioural effects in mammals: inhibition of intake of food and wat...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/0196-9781(85)90348-1
更新日期：1985-01-01 00:00:00
abstract：:The binding of monoiodo 125I-Trp11-neurotensin to purified rat gastric fundus smooth muscle plasma membranes was characterized. Specific binding of ligand in subcellular fractions from rat fundus smooth muscle showed a distribution that paralleled that of several plasma membrane marker enzymes. 125I-Trp11-neurotensin ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90117-7
更新日期：1984-09-01 00:00:00
abstract：:Tardive dyskinesia, a clinical syndrome, is one of the major side effects of protracted treatment with neuroleptics in schizophrenic patients. Functional supersensitivity of striatal dopamine receptors is believed to contribute to the pathogenesis of schizophrenia and tardive dyskinesia. In a rodent model of neurolept...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(87)90072-6
更新日期：1987-09-01 00:00:00
abstract：:The role of central neuropeptide Y (NPY) in the cardiovascular response to social stress was evaluated in freely moving rats using telemetry. In unstressed rats, intracerebroventricular (ICV) administration of NPY and the selective Y1 receptor agonist [Leu31, Pro34]-NPY decreased blood pressure and heart rate, while t...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00266-0
更新日期：1998-01-01 00:00:00
abstract：:Despite the high impact of the antimicrobial peptide hepcidin in iron homeostasis, the regulation of this hormone is still not completely understood. Studies concerning hepcidin regulation are performed at the mRNA level. For the first time we analyzed the regulation of hepcidin not only at mRNA, but also at protein l...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.01.016
更新日期：2007-05-01 00:00:00
abstract：:Growing evidence suggests that the neuropeptide Y (NPY) system plays an important role in the immune system. Yet, little is known about the expression of NPY and receptors in the immune system. Moreover, original contradicting results have confused the picture and hampered a clear understanding of its role in the immu...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2006.09.030
更新日期：2007-02-01 00:00:00
abstract：:Antimicrobial peptides allegedly exert their action on microbial membranes. Bovine lactoferrin enfold two antimicrobial domains, lactoferricin B (LFcin B) and lactoferrampin (LFampin). Effects of representative peptides thereof on the membranes of Candida albicans and Escherichia coli were investigated. Confocal laser...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.02.011
更新日期：2005-09-01 00:00:00
abstract：:The gut-derived hormone peptide YY (PYY) is most commonly known for its effect on satiety, decreasing food intake and body weight in animals and humans. However, PYY is also involved in a wide range of digestive functions including regulating insulin secretion and glucose homeostasis. Over the last few years, there ha...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2006.07.031
更新日期：2007-02-01 00:00:00
abstract：:Dipeptidyl peptidase-4 (DPP-4) inhibitor and exercise have proven to be effective treatments for diabetes. However, the effects of these interventions in compensatory hyperinsulinemia prediabetic period are unknown. The purpose of this study was to determine if these interventions have protective effects on β-cell fun...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.08.021
更新日期：2013-11-01 00:00:00
abstract：:Vasoactive intestinal peptide (VIP) is a potent anti-inflammatory agent. In addition to the deactivation of macrophages, dendritic cells, and microglia, VIP shifts the Th1/Th2 balance, promoting the preferential differentiation and survival of Th2 cells, to the detriment of the proinflammatory Th1 effectors. Several m...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.03.015
更新日期：2007-09-01 00:00:00
abstract：:Binding sites in the rat forebrain were characterized using (125I-Tyr4)bombesin as a receptor probe. Pharmacology experiments indicate that gastrin releasing peptide (GRP) and the GRP fragments GRP as well as Ac-GRP inhibited radiolabeled (Tyr4)bombesin binding with high affinity. Biochemistry experiments indicated th...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90018-x
更新日期：1985-01-01 00:00:00
abstract：:This review describes the role of modulation of intracellular adhesion molecule-1 (ICAM-1)/leukocyte function-associated antigen-1 (LFA-1) interaction in controlling autoimmune diseases or inducing immunotolerance. ICAM-1/LFA-1 interaction is essential for T-cell activation as well as for migration of T-cells to targe...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/s0196-9781(03)00083-4
更新日期：2003-03-01 00:00:00
abstract：:Obestatin is a second peptide derived from the preproghrelin polypeptide. It was originally thought to have anorexigenic effects, thereby functioning as an antagonist of ghrelin. However, this has been a subject of debate ever since. Since acylated ghrelin strongly induces insulin resistance, it could be hypothesized ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.09.011
更新日期：2008-12-01 00:00:00
abstract：:Defensins are essentially ancient natural antibiotics with potent activity extending from lower organisms to humans. They can inhibit the growth or virulence of micro-organisms directly or indirectly enhance the host's immune system. The successful prediction of defensin peptides will provide very useful information a...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.06.032
更新日期：2009-10-01 00:00:00
abstract：:The effect of intraplantarly (i.pl.)-injected methionine-enkephalin (ME) on Concanavalin A (Con A)-induced paw edema in Dark Agouti (DA) and Albino Oxford (AO) rats was investigated. ME suppressed edema in DA rats, which was antagonized with naloxone (non-selective opioid receptor antagonist) and naltrindole (delta op...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(02)00105-5
更新日期：2002-09-01 00:00:00
abstract：:In order to elucidate the relationship between secretory pathway and processing for precursor molecule of peptide hormones, we performed immunoelectron microscopic studies to localize POMC-derived peptides in mouse cultured L cells (fibroblasts without secretory granules) and in mouse AtT20 cells (ACTH secreting pitui...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(91)90092-4
更新日期：1991-05-01 00:00:00
abstract：:The incretin hormones, glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), potentiate insulin secretion and are responsible for the majority of insulin secretion that occurs after a meal. They may also, however, have a fundamental role in pancreatic beta cell development and functio...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2016.03.012
更新日期：2016-05-01 00:00:00
abstract：:The effects of CCK-8s and desulfated CCK-8 at concentrations ranging from 10(-14) to 10(-6) M were studied in vitro on several functions of human peripheral neutrophils: adherence to substrate, mobility (spontaneous and directed by a chemical gradient or chemotaxis), ingestion of inert particles (latex beads) or cells...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(96)00338-5
更新日期：1997-01-01 00:00:00
abstract：:In the present review we reevaluated the experimental and clinical evidence that there is a local renin angiotensin system in the heart as well as the presence of a functional intracrine component which is activated during pathological conditions like heart failure and hypertension. The implications of these findings ...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2011.06.018
更新日期：2011-08-01 00:00:00
