Abstract:
:The interindividual variability of the hydrolysis of leucine enkephalin, and of the formation of its hydrolysis by-products has been studied in human plasma. In agreement with known data, the data obtained indicate that Leu-enkephalin is degraded by several enzymes, belonging to three classes: aminopeptidases, dipeptidylaminopeptidases, and dipeptidylcarboxypeptidases. The relative ratio of the substrate degraded by each enzyme class-as well as the expression of the single enzyme species within each class-appears to be individually determined. Interindividual variability observed seems controlled by two main factors: the pattern of enkephalin-degrading enzymes and, more notably, the low molecular weight plasma inhibitors. Both these factors appear to be partially specific of each donor. Possibly because of the composition of these factors, the hydrolysis pattern of the substrate is characteristic of each donor, and constant in blood obtained from successive drawings, at least within a relatively short period of time.
journal_name
Peptidesjournal_title
Peptidesauthors
Marini M,Urbani A,Trani E,Bongiorno L,Roda LGdoi
10.1016/s0196-9781(97)00129-0subject
Has Abstractpub_date
1997-01-01 00:00:00pages
741-8issue
5eissn
0196-9781issn
1873-5169pii
S0196-9781(97)00129-0journal_volume
18pub_type
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