Pituitary adenylate cyclase activating polypeptide (PACAP) is a potent relaxant of the rat ileum.

abstract：:Glucagon-like peptide-1 (GLP-1) is a proglucagon-derived hormone with cellular protective actions. We hypothesized that GLP-1 would protect the endothelium from injury during inflammation. Our aims were to determine the: (1) effect of GLP-1 on basal microvascular permeability, (2) effect of GLP-1 on increased microvas...

journal_title：Peptides

authors： Dozier KC,Cureton EL,Kwan RO,Curran B,Sadjadi J,Victorino GP

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Since short bowel syndrome (SBS) patients face life-threatening conditions, the development of therapeutic strategies to induce intestinal adaptation has been investigated. Ghrelin, a ligand of growth hormone (GH) secretagogue-receptor that stimulates the release of GH and insulin like growth factor-1 (IGF-1...

journal_title：Peptides

authors： Onishi S,Kaji T,Yamada W,Nakame K,Machigashira S,Kawano M,Yano K,Harumatsu T,Yamada K,Masuya R,Kawano T,Mukai M,Hamada T,Souda M,Yoshioka T,Tanimoto A,Ieiri S

更新日期：2018-08-01 00:00:00

abstract：:Two peptides, rHRnG and hproHRnG, which were encoded by the nucleotide sequences complementary to mRNA of rat hypothalamic gonadotropin-releasing hormone (GnRH) and human placental proGnRH(-3-13), respectively, were synthesized. A remarkable hydropathic anti-complementarity was observed in the N-terminal region betwee...

journal_title：Peptides

authors： Görcs TJ,Gottschall PE,Coy DH,Arimura A

更新日期：1986-11-01 00:00:00

abstract：:Cone snails comprise approximately 700 species of venomous molluscs which have evolved the ability to generate multiple toxins with varied and exquisite selectivity. alpha-Conotoxin is a powerful tool for defining the composition and function of nicotinic acetylcholine receptors which play a crucial role in excitatory...

journal_title：Peptides

authors： Peng C,Han Y,Sanders T,Chew G,Liu J,Hawrot E,Chi C,Wang C

更新日期：2008-10-01 00:00:00

abstract：:The cholecystokinin receptor-type 1 (CCK1R) is a G-protein coupled receptor localized in the animal gastrointestinal tract. Receptor activation by the natural peptide ligand CCK leads to a feeling of satiety. In this study, hydrolysates from soy and milk proteins were evaluated for their potential to activate the CCK1...

journal_title：Peptides

authors： Staljanssens D,Van Camp J,Billiet A,De Meyer T,Al Shukor N,De Vos WH,Smagghe G

更新日期：2012-03-01 00:00:00

abstract：:Chicken-I and chicken-II gonadotropin-releasing hormone (cI-GnRH and cII-GnRH) were shown to be differentially distributed in the brain of a turtle, Trachemys scripta, by HPLC and specific radioimmunoassays. The cI-GnRH was most concentrated in the median eminence (ME), while cII-GnRH was most concentrated in the caud...

journal_title：Peptides

authors： Tsai PS,Licht P

更新日期：1993-03-01 00:00:00

abstract：:We have attempted to demonstrate a pancreatic secretory response to intraduodenal amino acids in the anesthetized cat. In four cats stimulated with supramaximal doses of secretin, protein concentrations in pancreatic juice were measured after intraduodenal bolus injection of various amino acids, IV CCK, or electrical ...

journal_title：Peptides

authors： Johnson C,Jeanningros R,Sarles H

更新日期：1982-03-01 00:00:00

abstract：:Neuromedin B (NMB), which was originally isolated from porcine spinal cord, is a mammalian bombesin-related peptide that exerts various physiological effects. Previously, we observed expression of NMB in rib cartilage from chicken. Here, we report the initial attempt to elucidate the role of NMB in cartilage. We used ...

journal_title：Peptides

authors： Saito H,Ikeda R,Inoue K,Nagata S,Kitamura K,Minamino N,Kangawa K,Miyata A

更新日期：2012-08-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) stimulates endochondrial ossification by activating the transmembrane guanylyl cyclase, natriuretic peptide receptor-B (NPR-B). Recently, a spontaneous autosomal recessive mutation that causes severe dwarfism in mice was identified. The mutant, called long bone abnormality (lbab), cont...

journal_title：Peptides

authors： Yoder AR,Kruse AC,Earhart CA,Ohlendorf DH,Potter LR

更新日期：2008-09-01 00:00:00

abstract：:The major amyloid-beta (Abeta) peptides found in the brain of familial and late onset Alzheimer's disease include the full-length Abeta1-42 and N-terminally truncated, pyroglutamylated peptides Abetap3-42 and Abetap11-42. The biophysical properties of Abeta1-42 have been extensively studied, yet little is known about ...

journal_title：Peptides

authors： Sanders HM,Lust R,Teller JK

更新日期：2009-05-01 00:00:00

abstract：:For clinical use, it is essential to develop potent endomorphin (EM) analogs with reduced antinociceptive tolerance. In the present study, the antinociceptive activities and tolerance development of four potent EM-1 analogs with C-terminal oligoarginine-conjugation was evaluated and compared in the radiant heat paw wi...

journal_title：Peptides

authors： Yuan BY,Liu WZ,Wang XF,Zhang YZ,Yang DJ,Wang CL

更新日期：2018-08-01 00:00:00

abstract：:Trefoil factors family 2 (TFF2), also known as spasmolytic polypeptide, is primarily expressed in the mucus neck cells of gastrointestinal tracts. It has been proposed that TFF2 plays an important physiological role in protection, repair, and healing of gastrointestinal mucosa. To investigate the cis-acting regulatory...

journal_title：Peptides

authors： Chi AL,Lim S,Wang TC

更新日期：2004-05-01 00:00:00

abstract：:In the present study we used intracerebral microdialysis techniques to examine whether angiotensin II (ANG II) modulates the release of serotonin (5-hydroxytryptamine, 5-HT) in the subfornical organ (SFO) in freely moving rats. Extracellular concentrations of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA)...

journal_title：Peptides

authors： Tanaka J,Kariya K,Nomura M

更新日期：2003-06-01 00:00:00

abstract：:The hypocretins (1 and 2) have emerged as key regulators of sleep and wakefulness. We developed a high-throughput enzyme immunoassay (EIA) to measure total brain hypocretin levels from large numbers of mice. Hypocretin levels were not altered by circadian time or age. However, significant differences in one or both hy...

journal_title：Peptides

authors： Lin L,Wisor J,Shiba T,Taheri S,Yanai K,Wurts S,Lin X,Vitaterna M,Takahashi J,Lovenberg TW,Koehl M,Uhl G,Nishino S,Mignot E

更新日期：2002-12-01 00:00:00

abstract：:The effect of caseinomacropeptide (CMP) (the [106-169] fragment of kappa-casein produced during digestion of milk protein), was studied in anesthetized rats using bile diversion for a pure pancreatic juice collection system. Intraduodenal administration of CMP induced a dose-related specific stimulation of pancreatic ...

journal_title：Peptides

authors： Pedersen NL,Nagain-Domaine C,Mahé S,Chariot J,Rozé C,Tomé D

更新日期：2000-10-01 00:00:00

abstract：:The analysis of the spectrum of circular dichroism (CD) of methionine-oxidized bovine parathyroid hormone peptide, bPTH(1-34) revealed that approximately 43% of the orderly conformation (alpha-helix and beta-sheet) was converted into random coil structure. This peptide failed to elicit any hypotensive response in rats...

journal_title：Peptides

authors： Hong BS,Yang MC,Liang JN,Pang PK

更新日期：1986-11-01 00:00:00

abstract：:Although several low amphipathic peptides have been known to exhibit antimicrobial activity, their mode of action has not been completely elucidated. In this study, using designed low amphipathic peptides that retain different alpha-helical content and hydrophobicity, we attempted to investigate the mechanism of these...

journal_title：Peptides

authors： Yamamoto N,Tamura A

更新日期：2010-05-01 00:00:00

abstract：:Liver-expressed antimicrobial peptide 2 (LEAP-2) is a 40-residue cationic peptide originally purified from human blood ultrafiltrate. The native peptide contains two disulfide bonds and is unique regarding its primary structure. Its biological role is not known but a previous study showed that chemically synthesized L...

journal_title：Peptides

authors： Hocquellet A,Odaert B,Cabanne C,Noubhani A,Dieryck W,Joucla G,Le Senechal C,Milenkov M,Chaignepain S,Schmitter JM,Claverol S,Santarelli X,Dufourc EJ,Bonneu M,Garbay B,Costaglioli P

更新日期：2010-01-01 00:00:00

abstract：:The hypotensive effect of proadrenomedullin N-terminal 20 peptide (PAMP) was examined in conscious pregnant (8, 14, and 20 days of pregnancy) and nonpregnant rats. Intravenous administration of PAMP (3-60 nmol/kg) produced a dose-dependent depressor response in both pregnant and nonpregnant rats. However, the maximum ...

journal_title：Peptides

authors： Makino I,Makino Y,Kangawa K,Shibata K

更新日期：1999-12-01 00:00:00

abstract：:Three separate sets of receptors sensitive to VIP, GIP and pancreatic/entero-glucagons, have been characterized in HGT-1 cells. The order of relative potencies of VIP receptor agonists was VIP greater than rh GRF-43, rh GRF-29 greater than PHI greater than hp GRF-40, secretin. G-37 was about 4 times less potent than G...

journal_title：Peptides

authors： Emami S,Chastre E,Bodéré H,Gespach C,Bataille D,Rosselin G

更新日期：1986-01-01 00:00:00

abstract：:Skh-AMP1 (GRTSKQELCTWERGSVRQADKTIAG) is an antifungal peptide isolated from Satureja khuzistanica which has been shown to have strong antifungal activity against Aspergillus and Candida species, but no obvious hemolytic effects or cell cytotoxicity in vitro. In the present study, Skh-AMP1 was synthesized, and its mode...

journal_title：Peptides

authors： Khani S,Seyedjavadi SS,Hosseini HM,Goudarzi M,Valadbeigi S,Khatami S,Ajdary S,Eslamifar A,Amani J,Imani Fooladi AA,Razzaghi-Abyaneh M

更新日期：2020-01-01 00:00:00

abstract：:In this work, we characterized the active site in the alpha-melanotropin hormone (alpha-MSH) sequence responsible for the enhancement of cAMP production in incubated striatal slices by using different alpha-MSH fragments. We also analyzed the effects of the co-incubation of the SCH23390, a dopaminergic D(1) antagonist...

journal_title：Peptides

authors： Cecilia Cremer M,Silvina Sanchez M,Ester Celis M

更新日期：2000-06-01 00:00:00

abstract：:Male Holtzman albino and Long-Evans hooded rats were administered one microgram of arginine vasopressin (AVP) or a placebo each day after the acquisition trials of a visual white-black discrimination. Animals were then trained in the reversal of the discrimination. Performance was assessed by the number of trials to c...

journal_title：Peptides

authors： Tinius TP,Beckwith BE,Oltmanns D

更新日期：1989-01-01 00:00:00

abstract：:The presence of the proenkephalin A-derived peptide Met5-enkephalin-Arg6-Gly7-Leu8 was demonstrated throughout the human gastrointestinal tract. Highest concentrations of Met5-enkephalin-Arg6-Gly7-Leu8, as assessed by radioimmunoassay, were measured in the separated muscularis externa, while lower levels were found in...

journal_title：Peptides

authors： Ferri GL,Morreale RA,Dockray GJ

更新日期：1986-09-01 00:00:00

abstract：:Neurotensin has been demonstrated to be analgesic in rodents. This study used intrathecal injection of neurotensin in unanesthetized mice to evaluate the effect of the peptide at the spinal level on unconditioned behavior. Intrathecal administration of neurotensin produced dose-related inhibition of locomotor activity...

journal_title：Peptides

authors： Hylden JL,Wilcox GL

更新日期：1983-07-01 00:00:00

abstract：:Beta-amyloid (Aβ) peptides are secreted from neurons, resulting in extracellular accumulation of Aβ and neurodegeneration of Alzheimer's disease. Because neuronal secretion is fundamental for the release of neurotransmitters, this study assessed the hypothesis that Aβ undergoes co-release with neurotransmitters. Model...

journal_title：Peptides

authors： Toneff T,Funkelstein L,Mosier C,Abagyan A,Ziegler M,Hook V

更新日期：2013-08-01 00:00:00

abstract：:alpha-MSH immunoreactive peptides were fractionated and characterized in rat and human brain and rat pituitary by reversed phase high pressure liquid chromatographic techniques. alpha-MSH and deacetylated alpha-MSH were two major naturally existing peptides in both brain and pituitary gland. Subsequent experiments exa...

journal_title：Peptides

authors： O'Donohue TL,Handelmann GE,Chaconas T,Miller RL,Jacobowitz DM

更新日期：1981-10-01 00:00:00

abstract：:The peptidome of the central nervous system of adult cabbage root fly, Delia radicum (L) was investigated using matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS). Over twenty neuropeptides were identified from three different tissue sources, the combined brain/suboesophageal g...

journal_title：Peptides

authors： Audsley N,Matthews HJ,Down RE,Weaver RJ

更新日期：2011-03-01 00:00:00

abstract：:Peptides of the adipokinetic hormone (AKH)/red pigment-concentrating hormone (RPCH) family were isolated and sequenced from the retrocerebral corpora cardiaca of four kissing bugs which are all vectors of the protozoan Trypanosoma cruzi responsible for Chagas' disease. The sequence of three novel AKHs were deduced fro...

journal_title：Peptides

authors： Marco HG,Simek P,Clark KD,Gäde G

更新日期：2013-03-01 00:00:00

abstract：:Degradation of Boc CCK7 (Boc Tyr1 (SO3H)-Met2-Gly3-Trp4-Met5-Asp6-Phe7-NH2), a fully active analog of CCK8, by purified rabbit kidney neutral metalloendopeptidase (enkephalinase) was studied as a basis for the rational design of potent peptidases-resistant analogs of cholecystokinin. Characterization of the metabolite...

journal_title：Peptides

authors： Durieux C,Charpentier B,Fellion E,Gacel G,Pelaprat D,Roques BP

更新日期：1985-05-01 00:00:00