Amyloid-beta peptide Abetap3-42 affects early aggregation of full-length Abeta1-42.

abstract：:Apelin was recently found to be an inotropic polypeptide in isolated rat hearts, and intravenous injection of apelin can induce a transient decrease in blood pressure. To illustrate the mechanism of apelin-induced vasodilation, we observed the in vitro effects of apelin on the L-arginine (L-Arg)/nitric oxide (NO) path...

journal_title：Peptides

authors： Jia YX,Lu ZF,Zhang J,Pan CS,Yang JH,Zhao J,Yu F,Duan XH,Tang CS,Qi YF

更新日期：2007-10-01 00:00:00

abstract：:The cervical sympathetic trunk-submandibular gland neuroendocrine axis plays an integral role in physiological adaptations and contributes to the maintenance of systemic homeostasis, particularly under the 'stress conditions' seen with tissue damage, inflammation, and aggressive behavior. The variety of polypeptides, ...

journal_title：Peptides

authors： Rougeot C,Rosinski-Chupin I,Mathison R,Rougeon F

更新日期：2000-03-01 00:00:00

abstract：:The gastrin-releasing peptide receptor (GRPR) has been implicated in the modulation of emotionally-motivated memory. In the present study, we investigated the role of the GRPR on non-emotional, non-associative memory, and anxiety. Adult male Wistar rats were given a systemic injection of the GRPR antagonist [D-Tpi6, L...

journal_title：Peptides

authors： Martins MR,Reinke A,Valvassori SS,Machado RA,Quevedo J,Schwartsmann G,Roesler R

更新日期：2005-12-01 00:00:00

abstract：:Three neurotensin (NT) receptors have been cloned to date, two of which, NTS1 and NTS2, belong to the family of seven transmembrane domain receptors coupled to G proteins (GPCRs). NTS1 and NTS2 may activate multiple signal transduction pathways, involving several G proteins. However, whereas NT acts as an agonist towa...

journal_title：Peptides

authors： Pelaprat D

更新日期：2006-10-01 00:00:00

abstract：:Cellular actions of nociceptin/orphanin FQ (N/OFQ) resemble those of micro-, delta-, and kappa-opioids, i.e. activation of inwardly rectifying K(+) conductance, inhibition of high-voltage-activated Ca(2+) channel currents, and impediment of neurotransmitter release. Differences in ORL(1) and micro-receptor distributio...

journal_title：Peptides

authors： Moran TD,Abdulla FA,Smith PA

更新日期：2000-07-01 00:00:00

abstract：:Rhesus monkey MCH-R1 and MCH-R2 receptors were cloned. Amino acid homology is 98.8% between monkey and human MCH-R1, while monkey and human MCH-R2 are 98% homologous. Binding and intracellular signaling characteristics of the monkey receptors were compared with the human homologues. The results demonstrate that MCH bi...

journal_title：Peptides

authors： Fried S,O'Neill K,Hawes BE

更新日期：2002-08-01 00:00:00

abstract：:We sought to establish Endothelin (ET-3) role in the central regulation of bile secretion in the rat. The intracerebroventricular (icv) injection of ET-3 evoked a cholestatic or a choleretic effect depending on the administered dose. Lower doses increased bile flow and bicarbonate excretion, whereas higher doses decre...

journal_title：Peptides

authors： Rodríguez MR,Sabbatini ME,Santella G,Dabas P,Villagra A,Vatta MS,Bianciotti LG

更新日期：2005-07-01 00:00:00

abstract：:Adjacent tissue sections through the rat median eminence were examined for the distribution of gonadotropin-releasing hormone (GnRH) and catecholamines (CA). A simultaneous visualization technique was employed for this correlative neuroanatomical analysis. At rostral and mid-central levels of the median eminence the m...

journal_title：Peptides

authors： McNeill TH,Scott DE,Sladek JR Jr

更新日期：1980-04-01 00:00:00

abstract：:In this work, we characterized the active site in the alpha-melanotropin hormone (alpha-MSH) sequence responsible for the enhancement of cAMP production in incubated striatal slices by using different alpha-MSH fragments. We also analyzed the effects of the co-incubation of the SCH23390, a dopaminergic D(1) antagonist...

journal_title：Peptides

authors： Cecilia Cremer M,Silvina Sanchez M,Ester Celis M

更新日期：2000-06-01 00:00:00

abstract：:The effects of hypergravity on the gene expression of the hypothalamic feeding-related neuropeptides in sham-operated (Sham) and vestibular-lesioned (VL) mice were examined by in situ hybridization histochemistry. Corticotrophin-releasing hormone (CRH) in the paraventricular nucleus was increased significantly in Sham...

journal_title：Peptides

authors： Sonoda S,Yoshimura M,Abe C,Morita H,Ueno H,Motojima Y,Saito R,Maruyama T,Hashimoto H,Tanaka Y,Ueta Y

更新日期：2018-07-01 00:00:00

abstract：:Inhibitors of metallopeptidases may represent new alternatives in the treatment of cardiovascular disease. Recent investigations have linked the hypotensive properties of the metalloendopeptidase 3.4.24.15 (MEP 24.15) inhibitor c-phenylpropyl-alanyl-alanyl-phenylalanyl-para-aminobenzoate (cFP-A-A-F-pAB) to the attenua...

journal_title：Peptides

authors： Chappell MC,Welches WR,Brosnihan KB,Ferrario CM

更新日期：1992-09-01 00:00:00

abstract：:Concentrations of immunoreactive galanin were compared in eight gross brain regions of ovariectomized female rats treated with either estradiol, estradiol + progesterone, estradiol + norethisterone, or placebo. Higher concentrations with estradiol treatment compared with placebo were found in the pituitary (357%), fro...

journal_title：Peptides

authors： Rugarn O,Theodorsson A,Hammar M,Theodorsson E

更新日期：1999-01-01 00:00:00

abstract：:The elevated T-maze was combined with a free exploration protocol, which, in contrast to the conventional procedure, dispenses with handling of the animals during the experimental sessions. This allows measurement of fear indexes derived from the elevated plus-maze as well as assessment of acquisition of open arm avoi...

journal_title：Peptides

authors： Echeverry MB,Hasenöhrl RU,Huston JP,Tomaz C

更新日期：2001-07-01 00:00:00

abstract：:VIP and secretin control the secretory function of the normal pancreas. We analysed their regulatory functions in a human pancreatic cancer cell line: Capan-1. Saturation binding experiments with 125I-VIP showed the existence of one class of binding sites of very high affinity: KD 6.4 +/- 3.0 X 10(-11) M and a low Bma...

journal_title：Peptides

authors： Ruellan C,Scemama JL,Clerc P,Fagot-Revurat P,Clemente F,Ribet A

更新日期：1986-01-01 00:00:00

abstract：:Guanylyl cyclases (GC) are widely distributed enzymes that signal via the production of the second messenger cGMP. The particulate guanylyl cyclases share a similar topology: an extracellular ligand binding domain and intracellular regulatory kinase-homology and cyclase catalytic domains. The natriuretic peptide recep...

journal_title：Peptides

authors： Schulz S

更新日期：2005-06-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide with strong bronchodilator capacity, present in the human airways. There is recent evidence that PACAP decreases the release of proinflammatory cytokines. We have previously shown that PACAP inhibits neutrophil chemotaxis, but altogether little i...

journal_title：Peptides

authors： Kinhult J,Egesten A,Uddman R,Cardell LO

更新日期：2002-10-01 00:00:00

abstract：:Recent studies have identified compounds with reduced efficacy relative to nociceptin/orphanin FQ at the opioid-like receptor ORL1. Utilizing stimulation of [(35)S]GTPgammaS binding as in vitro assays, it was determined that both [Phe(1)psi(CH(2)-NH)Gly(2)]N/OFQ(1-13)NH(2) and the hexapeptide Ac-RYYRIK-NH(2) act as pa...

journal_title：Peptides

authors： Burnside JL,Rodriguez L,Toll L

更新日期：2000-07-01 00:00:00

abstract：:The binding activity of several galanin fragments and analogs was measured on specific receptors present in rat brain and the rat pancreatic beta cell line Rin m 5F. In both tissues it was observed that: 1) galanin(3-29), galanin(10-29) and [Ile2]-galanin were ineffective for inhibiting [125I] galanin binding and 2) a...

journal_title：Peptides

authors： Lagny-Pourmir I,Lorinet AM,Yanaihara N,Laburthe M

更新日期：1989-07-01 00:00:00

abstract：:Interdigestive migrating contractions (IMC) were analyzed for their occurrence interval, duration, migrating velocity, and frequently in long term records obtained by means of chronically implanted force transducers in the main stomach and the extrinsically denervated fundic pouches or in the intact jejunum and the ex...

journal_title：Peptides

authors： Itoh Z,Nakaya M,Suzuki T

更新日期：1981-01-01 00:00:00

abstract：:Morphologic and immunohistochemical studies were conducted to ascertain whether pumiliotoxin-B (PTX-B), an indolizine alkaloid from the skin of the Neotropical dendrobatid frog, Dendrobates pumilio, affects the anatomic and immunohistochemical features of the electrically stimulated mouse vas deferens preparations. PT...

journal_title：Peptides

authors： D'Este L,Falconieri-Erspamer G,Severini C,Erspamer V,Renda TG

更新日期：1999-01-01 00:00:00

abstract：:The effects of dipeptide cyclo-[His-Pro] (CHP), known to participate in the appetite behavior and food intake control, have been investigated using PC12 cells in culture as model system. We found that only in the presence of experimental conditions that cause cellular stress the cyclic dipeptide affect cellular prolif...

journal_title：Peptides

authors： Minelli A,Bellezza I,Grottelli S,Pinnen F,Brunetti L,Vacca M

更新日期：2006-01-01 00:00:00

abstract：:The neuropeptide S (NPS) system is characterized by a unique pharmacology because it has anxiolytic-like effects and promotes arousal and wakefulness. To shed light on this peptidergic system, we tested the sedative effect of the central depressants diazepam and ethanol on the loss of righting reflex in mice lacking t...

journal_title：Peptides

authors： Ghazal P,Corsi M,Roth A,Faggioni F,Corti C,Merlo Pick E,Pucciarelli S,Ciccocioppo R,Ubaldi M

更新日期：2014-11-01 00:00:00

abstract：:We have cloned melanocortin receptors (MCRs) from several species of fish. The MC4R and MC5R subtypes arose early in vertebrate evolution and their primary structure is remarkably conserved. Expression and pharmacological characterization of the MCRs in fish has revealed that they bind and respond to melanocortin pept...

journal_title：Peptides

authors： Schiöth HB,Haitina T,Ling MK,Ringholm A,Fredriksson R,Cerdá-Reverter JM,Klovins J

更新日期：2005-10-01 00:00:00

abstract：:HPLC characterization of tilapia pituitary endorphins using an antibody specific for N-terminally acetylated endorphins yielded three major peaks in the neurointermediate lobe, but none in the pars distalis. The melanotropes secreted two of the immunoreactive products in vitro, one of which coeluted with Xenopus laevi...

journal_title：Peptides

authors： Balm PH,Hovens ML,Wendelaar Bonga SE

更新日期：1995-01-01 00:00:00

abstract：:In this study we examined the effects of 2% saline loading (S), partial restriction of water consumption (R) or a combination of S or R with dexamethasone (DEX) treatment for 14 days on corticotropin releasing factor (CRF)-41 content of the neurointermediate lobe (NIL) and supraoptic nuclei (SON) of male Wistar rats. ...

journal_title：Peptides

authors： Dohanics J,Linton EA,Lowry PJ,Makara GB

更新日期：1990-01-01 00:00:00

abstract：:Echinometra lucunter is an abundant sea urchin found in Brazilian waters. Accidents caused by this animal are common and are characterized by the penetration of the spines in the skin, which raises an inflammatory reaction through mechanical trauma as well as by the presumable action of toxins. Additionally, there hav...

journal_title：Peptides

authors： Sciani JM,Sampaio MC,Zychar BC,Gonçalves LR,Giorgi R,Nogueira Tde O,de Melo RL,Teixeira Cde F,Pimenta DC

更新日期：2014-03-01 00:00:00

abstract：:We employed a proteomic approach to search for peptides that have a physiological role in labor. Cervicovaginal secretions were collected at term from women in labor and women at term not in labor. Samples were spotted onto weak cation exchange chips (WCX-2) and analyzed using Surface-Enhanced Laser Desorption Ionizat...

journal_title：Peptides

authors： Brown AG,Leite RS,Engler AJ,Discher DE,Strauss JF 3rd

更新日期：2006-07-01 00:00:00

abstract：:In this study, we present evidence showing that endothelin (ET) potentiates the responses to adenosine, to 5'-N-ethylcarboxamidoad, a nonhydrolyzable adenosine agonist, and to isoprenaline. These responses seem to occur through ET-B receptors, as all three endothelin isopeptides have the same potency, sarafotoxin 6c h...

journal_title：Peptides

authors： Hernández F,Catalán RE,Martinez AM

更新日期：1999-01-01 00:00:00

abstract：:In the crayfish Astacus leptodactylus, as in several crustacean species, the crustacean hyperglycemic hormone is present as two isoforms differing by the chirality of the third residue, a phenylalanine. In the present work, isoforms synthesized full length by solid-phase peptide synthesis have been purified, refolded,...

journal_title：Peptides

authors： Lebaupain F,Boscameric M,Pilet E,Soyez D,Kamech N

更新日期：2012-03-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) immunoreactive material has been found in extracts of the intestine, however, the structure of intestinal CGRP is not known. Analytical reverse phase HPLC and ion-exchange FPLC revealed one predominant immunoreactive CGRP peak in rabbit intestinal extracts. This material was puri...

journal_title：Peptides

authors： Eysselein VE,Reeve JR Jr,Sternini C,Cominelli F,Davis WM,Davis MT,Lee TD,Ho FJ,Ridout D,Shively JE

更新日期：1991-03-01 00:00:00