Abstract:
:Three neurotensin (NT) receptors have been cloned to date, two of which, NTS1 and NTS2, belong to the family of seven transmembrane domain receptors coupled to G proteins (GPCRs). NTS1 and NTS2 may activate multiple signal transduction pathways, involving several G proteins. However, whereas NT acts as an agonist towards all NTS1-mediated pathways, this peptide may exert either agonist or antagonist activities, depending on the NTS2-mediated pathway in question. Studies on these receptors reinforce the concept of independence between multiple signals potentially mediated through a single GPCR, generating a wide diversity of functional responses depending on the host cell and the ligand.
journal_name
Peptidesjournal_title
Peptidesauthors
Pelaprat Ddoi
10.1016/j.peptides.2006.04.027subject
Has Abstractpub_date
2006-10-01 00:00:00pages
2476-87issue
10eissn
0196-9781issn
1873-5169pii
S0196-9781(06)00298-1journal_volume
27pub_type
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