Melanin-concentrating hormone in the human brain.

abstract：:Bombesin (BBS) at doses of 0.1, 1.0, 10.0 and 100.0 nM stimulated chemiluminescence (CL) production by phagocytic cells (monocytes, macrophages and polymorphonuclear leucocytes) in mice in the presence of ZAP (opsonized zymosan particles containing luminol). These data suggest that BBS increased the phagocytic functio...

journal_title：Peptides

authors： Jin GF,Guo YS,Smith ER,Houston CW

更新日期：1990-03-01 00:00:00

abstract：:BMAP-27, a member of cathelicidin family, plays an important role against microorganisms, including bacteria and fungi. BMAP-27 may exert antimicrobial effects through membrane integrity disruption, but the exact molecular mechanism remains unclear. To identify the structural features important for antimicrobial activ...

journal_title：Peptides

authors： Yang S,Lee CW,Kim HJ,Jung HH,Kim JI,Shin SY,Shin SH

更新日期：2019-08-01 00:00:00

abstract：:The striatum is richly innervated by both enkephalinergic and dopaminergic neurons, providing an anatomic framework from which intimate functional interrelationships between these neuronal systems may be postulated. Accordingly, many functional processes within dopamine neurons have been shown to be modulated by opioi...

journal_title：Peptides

authors： George SR,Kertesz M

更新日期：1987-05-01 00:00:00

abstract：:The effects of arginine vasotocin (AVT), 4-6 ng/kg, on renal function and plasma prolactin (PRL) were determined in conscious American foxhounds undergoing a water diuresis. Intravenous AVT produced an antidiuresis, kaliuresis and inconsistent natriuresis, independently of changes in GFR, blood pressure, heart rate an...

journal_title：Peptides

authors： Gilmore JP,Wesley CR,Huffman L,Nemeh MN

更新日期：1982-11-01 00:00:00

abstract：:Several studies have documented cardiovascular effects of apelin, including enhanced inotropy and vasodilation. However, these cardiovascular effects are short lived due to the predicted short circulating half-life of the apelin peptide. To address this limitation of apelin, we pursued N-terminal PEGylation of apelin ...

journal_title：Peptides

authors： Jia ZQ,Hou L,Leger A,Wu I,Kudej AB,Stefano J,Jiang C,Pan CQ,Akita GY

更新日期：2012-11-01 00:00:00

abstract：:Neurotensin-like immunoreactive neuronal perikarya, fibers and terminals in in the rat hypothalamus were investigated by light and electron microscopic immunocytochemistry. Distributional density and pattern of these elements were clarified. Fine structure of immunoreactive neuronal perikarya with respect to developme...

journal_title：Peptides

authors： Ibata Y,Kawakami F,Fukui K,Okamura H,Obata-Tsuto HL,Tsuto T,Terubayashi H

更新日期：1984-01-01 00:00:00

abstract：:Baboons received a 5-minute intravenous infusion of either saline or bombesin (BBS; 1-4 micrograms/kg) following 3 1/2 or 16 1/2 hours of food deprivation and were then allowed to eat for 30 minutes. Plasma insulin was significantly elevated following five minutes of BBS infusion, but there was no change of plasma glu...

journal_title：Peptides

authors： Woods SC,Stein LJ,Figlewicz DP,Porte D Jr

更新日期：1983-09-01 00:00:00

abstract：:Lipocalin-2 (LCN-2), a peptide with diverse expression pattern, has been identified as a biomarker of various diseases as well as a factor contributing to inflammatory responses associated with excess adiposity and ensuing metabolic disorders. Although the inter-relationship between LCN-2 and excess adiposity is incre...

journal_title：Peptides

authors： Singh RG,Nguyen NN,Cervantes A,Kim JU,Stuart CE,Petrov MS

更新日期：2019-09-01 00:00:00

abstract：:Insulin-like peptides (ILPs) affect a wide variety of biological events, such as metabolism, lifespan, growth and reproduction. Two ILPs (Spoli-ILP1 and Spoli-ILP2) were identified in the cotton leafworm, Spodoptera littoralis, while the functions and developmental characters are not fully understood. In the present s...

journal_title：Peptides

authors： Iga M,Smagghe G

更新日期：2011-03-01 00:00:00

abstract：:Recent studies have identified compounds with reduced efficacy relative to nociceptin/orphanin FQ at the opioid-like receptor ORL1. Utilizing stimulation of [(35)S]GTPgammaS binding as in vitro assays, it was determined that both [Phe(1)psi(CH(2)-NH)Gly(2)]N/OFQ(1-13)NH(2) and the hexapeptide Ac-RYYRIK-NH(2) act as pa...

journal_title：Peptides

authors： Burnside JL,Rodriguez L,Toll L

更新日期：2000-07-01 00:00:00

abstract：:Sex pheromone biosynthesis in many moth species is controlled by a cerebral neuropeptide, termed pheromone biosynthesis activating neuropeptide (PBAN). PBAN is a 33 amino acid C-terminally amidated neuropeptide that is produced by neuroendocrine cells of the subesophageal ganglion (SEG). Studies of the regulation of s...

journal_title：Peptides

authors： Altstein M

更新日期：2004-09-01 00:00:00

abstract：:Originally characterized in terms of its gastric acid inhibitory properties, GIP (gastric inhibitory polypeptide) expressed in the upper small intestine, was subsequently shown to exert strong glucose-dependent insulin-releasing properties. This action is generally attributed to GIP(1-42) and, so far, no evidence for ...

journal_title：Peptides

authors： Fehmann HC,Göke B

更新日期：1995-01-01 00:00:00

abstract：:Trefoil factors (TFFs) 1, 2 and 3 are small polypeptides that are co-secreted with mucin throughout the body. They are up-regulated in cancer and inflammatory processes in the gastrointestinal system, where they are proposed to be involved in tissue regeneration, proliferation and protection. Our aim was to explore th...

journal_title：Peptides

authors： Viby NE,Nexø E,Kissow H,Andreassen H,Clementsen P,Thim L,Poulsen SS

更新日期：2015-01-01 00:00:00

abstract：:Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and...

journal_title：Peptides

authors： Radulović J,Dimitrijević M,Laban O,Stanojević S,Vasiljević T,Kovacević-Jovanović V,Marković BM

更新日期：1995-01-01 00:00:00

abstract：:The purpose of this study was to examine the resting and exercise response patterns of plasma Peptide F immunoreactivity (ir) to altitude exposure (4300 m) and caffeine ingestion (4 mg.kg b.w.-1). Nine healthy male subjects performed exercise tests to exhaustion (80-85% VO2max) at sea level (50 m), during an acute alt...

journal_title：Peptides

authors： Kraemer WJ,Rock PB,Fulco CS,Gordon SE,Bonner JP,Cruthirds CD,Marchitelli LJ,Trad L,Cymerman A

更新日期：1988-09-01 00:00:00

abstract：:Concentrations of immunoreactive galanin were compared in eight gross brain regions of ovariectomized female rats treated with either estradiol, estradiol + progesterone, estradiol + norethisterone, or placebo. Higher concentrations with estradiol treatment compared with placebo were found in the pituitary (357%), fro...

journal_title：Peptides

authors： Rugarn O,Theodorsson A,Hammar M,Theodorsson E

更新日期：1999-01-01 00:00:00

abstract：:An antifungal peptide with a molecular mass of 9 kDa was isolated from fresh fruiting bodies of the mushroom Agrocybe cylindracea. The isolation procedure comprised ion exchange chromatography on DEAE-cellulose, affinity chromatography on Affi-gel blue gel, ion exchange chromatography by fast protein liquid chromatogr...

journal_title：Peptides

authors： Ngai PH,Zhao Z,Ng TB

更新日期：2005-02-01 00:00:00

abstract：:Beta-amyloid (Aβ) peptides are secreted from neurons, resulting in extracellular accumulation of Aβ and neurodegeneration of Alzheimer's disease. Because neuronal secretion is fundamental for the release of neurotransmitters, this study assessed the hypothesis that Aβ undergoes co-release with neurotransmitters. Model...

journal_title：Peptides

authors： Toneff T,Funkelstein L,Mosier C,Abagyan A,Ziegler M,Hook V

更新日期：2013-08-01 00:00:00

abstract：:Human beta-defensin 2 (hBD-2) is a 41-amino acid cationic peptide of the innate immune system that serves as antimicrobial molecule. We determined the bactericidal activity of synthetic hBD-2 against nosocomial strains belonging to eight different bacterial species and exhibiting various antimicrobial resistance pheno...

journal_title：Peptides

authors： Routsias JG,Karagounis P,Parvulesku G,Legakis NJ,Tsakris A

更新日期：2010-09-01 00:00:00

abstract：:Adjacent tissue sections through the rat median eminence were examined for the distribution of gonadotropin-releasing hormone (GnRH) and catecholamines (CA). A simultaneous visualization technique was employed for this correlative neuroanatomical analysis. At rostral and mid-central levels of the median eminence the m...

journal_title：Peptides

authors： McNeill TH,Scott DE,Sladek JR Jr

更新日期：1980-04-01 00:00:00

abstract：:One novel Kunitz BPTI-like peptide designated as BBPTI-1, with chymotrypsin inhibitory activity was identified from the venom of Burmese Daboia russelii siamensis. It was purified by three steps of chromatography including gel filtration, cation exchange and reversed phase. A partial N-terminal sequence of BBPTI-1, HD...

journal_title：Peptides

authors： Guo CT,McClean S,Shaw C,Rao PF,Ye MY,Bjourson AJ

更新日期：2013-05-01 00:00:00

abstract：:Prothymosin alpha (ProTα), a nuclear protein, plays multiple functions including cell survival. Most recently, we demonstrated that the active 30-amino acid peptide sequence/P30 (amino acids 49-78) in ProTα retains its substantial activity in neuroprotection in vitro and in vivo as well as in the inhibition of cerebra...

journal_title：Peptides

authors： Halder SK,Sugimoto J,Matsunaga H,Ueda H

更新日期：2013-05-01 00:00:00

abstract：:The in vivo effects of JMV-320 (a highly selective CCKB receptor ligand) and of CCK-4 on exploratory activity and memory in rats were compared. JMV-320 and CCK-4 did not modulate exploratory activity in an open field test but decreased it in an elevated plus-maze. CCK-4 (50 micrograms/kg) impaired passive avoidance re...

journal_title：Peptides

authors： Hadjiivanova C,Kehayov R,Petkov VV,Amblard M,Martinez J

更新日期：1995-01-01 00:00:00

abstract：:The aim of this study was to compare the actions of CCK neuropeptides within the nucleus accumbens (N.Acc) of alcohol preferring (Fawn-Hooded, FH) and alcohol nonpreferring (Wistar-Kyoto, WKY) rats. CCK-8S (30-300 nM) facilitated the K(+) stimulated release of [(3)H]dopamine (DA) from N.Acc prisms in both rat strains,...

journal_title：Peptides

authors： Lodge DJ,Short JL,Mercer LD,Beart PM,Lawrence AJ

更新日期：2000-03-01 00:00:00

abstract：:The effects of Pro-Leu-Gly-NH2 (melanotropin release inhibiting factor, MIF) and its analog, cyclo (Leu-Gly) on the mouse and rat striatal cholinergic muscarinic receptors labeled with 3H-quinuclidinyl benzilate (QNB) were investigated. 3H-QNB bound to the rat striatal muscarinic receptors at a single high affinity si...

journal_title：Peptides

authors： Das S,Matwyshyn GA,Bhargava HN

更新日期：1986-01-01 00:00:00

abstract：:Neurotensin has been demonstrated to be analgesic in rodents. This study used intrathecal injection of neurotensin in unanesthetized mice to evaluate the effect of the peptide at the spinal level on unconditioned behavior. Intrathecal administration of neurotensin produced dose-related inhibition of locomotor activity...

journal_title：Peptides

authors： Hylden JL,Wilcox GL

更新日期：1983-07-01 00:00:00

abstract：:Bradykinin (BK) has been proposed as the principal mediator of hypersensitivity reactions (HSR) in patients dialyzed using negatively charged membranes and concomitantly treated with angiotensin-converting enzyme (ACE) inhibitors. We investigated the metabolism of exogenous BK added to the sera of 13 patients dialyzed...

journal_title：Peptides

authors： Blais C Jr,Marc-Aurèle J,Simmons WH,Loute G,Thibault P,Skidgel RA,Adam A

更新日期：1999-01-01 00:00:00

abstract：:Somatostatin is reported in a new population of human sweat duct cells. The epithelial content of somatostatin-like immunoreactivity in normal human skin from various sites of the body was investigated using indirect immunofluorescence. With this methodology we found round-to-oval somatostatin-immunoreactive cells sit...

journal_title：Peptides

authors： Johansson O,Hilliges M,Wang L

更新日期：1993-03-01 00:00:00

abstract：:Ghrelin, a novel gut hormone, has been shown to exert protective effects on cardiac dysfunction and remodeling. However, the underlying mechanisms of its protective effects remain unclear. Here, we investigated the effects of ghrelin on cardiac hypertrophy and explored the mechanisms involved. Ghrelin (30 μg.kg-1. day...

journal_title：Peptides

authors： Lu W,Cai H,Chen Y,Liao X,Zhang L,Ma T,Sun H,Qi Y

更新日期：2020-11-13 00:00:00

abstract：:Legionella pneumophila, the causative agent of Legionnaires' disease, is a waterborne bacteria. It can multiply in man-made water systems and infect people who inhale contaminated droplets. We have previously reported a Staphylococcus warneri strain that display an anti-Legionella activity. In this work, we characteri...

journal_title：Peptides

authors： Verdon J,Berjeaud JM,Lacombe C,Héchard Y

更新日期：2008-06-01 00:00:00