Abstract：
:Sex pheromone biosynthesis in many moth species is controlled by a cerebral neuropeptide, termed pheromone biosynthesis activating neuropeptide (PBAN). PBAN is a 33 amino acid C-terminally amidated neuropeptide that is produced by neuroendocrine cells of the subesophageal ganglion (SEG). Studies of the regulation of sex pheromone biosynthesis in moths have revealed that this function can be elicited by additional neuropeptides all of which share the common C-terminal pentapeptide FXPRL-amide (X = S, T, G, V). In the past two decades extensive studies were carried out on the chemical, cellular and molecular aspects of PBAN and the other peptides (termed the pyrokinin (PK)/PBAN family) aiming to understand the mode of their action on sex pheromone biosynthesis. In the present review we focus on a few of these aspects, specifically on the: (i) structure-activity relationship (SAR) of the PK/PBAN family, (ii) characterization of the PK/PBAN receptor and (iii) development of a novel strategy for the generation of PK/PBAN antagonists and their employment in studying the mode of action of the PK/PBAN peptides.
journal_name
Peptidesjournal_title
Peptidesauthors
Altstein Mdoi
10.1016/j.peptides.2004.06.020subject
Has Abstractpub_date
2004-09-01 00:00:00pages
1491-501issue
9eissn
0196-9781issn
1873-5169pii
S0196-9781(04)00297-9journal_volume
25pub_type
杂志文章,评审相关文献
PEPTIDES文献大全abstract：:Combined use of the intraaxonal retrograde transport of the fluorescent marker 'true blue' with substance P (SP) immunocytochemistry has been used to trace the nodose ganglion projections of SP-containing neurons of the aortic depressor nerve. It has been found that (1) SP immunoreactive (SP-I) cell bodies are clearly...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(80)90015-7
更新日期：1980-01-01 00:00:00
abstract：:Endomorphin 1 (EM-1) and EM-2 have been widely reported in the cells of the central nervous system (CNS) but limited research has been done regarding their distribution in the peripheral system. The occurrence of EM-1 and -2 in the spleen as measured by RIA and their ability to mediate immune function imply a role for...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2003.11.016
更新日期：2004-01-01 00:00:00
abstract：:Alternaria alternata protein, Alt a 1 is a major allergen associated with allergy in atopic patients. Although the molecule binds strongly to IgE antibody from patients, the epitopes involved have not been identified or defined. In the present study, we synthesized overlapping peptides spanning the whole sequence and ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(03)00024-x
更新日期：2003-02-01 00:00:00
abstract：:In an attempt to establish the role of F8Famide in opioid activity modulation, we examined the effects of intracerebroventricular administration of the F8Famide analogs (1DME)Y8Fa and (3D)Y8Fa on intestinal transit in mice. (1DME)Y8Fa (0.88 to 22 nmol) inhibited intestinal transit as did F8Famide and morphine. An IP i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90108-s
更新日期：1993-07-01 00:00:00
abstract：:Cellular uptake of [125I] labelled DSIP at the luminal interface of the blood-brain barrier (BBB) was studied in the ipsilateral perfused in situ guinea pig forebrain. Regional unidirectional transfer constants (Kin) calculated from the multiple-time brain uptake analysis were 0.93, 1.33 and 1.66 microliter.min-1 g-1 ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(89)90026-0
更新日期：1989-03-01 00:00:00
abstract：:The antibacterial activity of peptides without disulfide bridges, spanning the carboxy-terminal segment of arthropod defensins, has been investigated. Although all the peptides have net positive charges, they exhibited varying antibacterial potencies and spectra. Atomic force and fluorescence microscopic analyses indi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.06.010
更新日期：2006-11-01 00:00:00
abstract：:Peptides of the adipokinetic hormone (AKH)/red pigment-concentrating hormone (RPCH) family were isolated and sequenced from the retrocerebral corpora cardiaca of four kissing bugs which are all vectors of the protozoan Trypanosoma cruzi responsible for Chagas' disease. The sequence of three novel AKHs were deduced fro...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.09.032
更新日期：2013-03-01 00:00:00
abstract：:Echinometra lucunter is an abundant sea urchin found in Brazilian waters. Accidents caused by this animal are common and are characterized by the penetration of the spines in the skin, which raises an inflammatory reaction through mechanical trauma as well as by the presumable action of toxins. Additionally, there hav...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.07.031
更新日期：2014-03-01 00:00:00
abstract：:We have recently characterized bicarinalin as the most abundant peptide from the venom of the ant Tetramorium bicarinatum. This antimicrobial peptide is active against Staphylococcus and Enterobacteriaceae. To further investigate the antimicrobial properties of this cationic and cysteine-free peptide, we have studied ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2016.04.001
更新日期：2016-05-01 00:00:00
abstract：:Members of the neprilysin family of neutral endopeptidases (M13) are typically membrane-bound enzymes known to be involved in the extra-cellular metabolism of signalling peptides and have important roles during mammalian embryogenesis. In this study we show that membranes prepared from embryos of Drosophila melanogast...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.08.032
更新日期：2007-01-01 00:00:00
abstract：:Radiation enteritis occurs as a response to abdominal radiation, which can cause mucosal damage in the gastrointestinal mucosal epithelium. The small intestine is one of the most radiosensitive organs in the abdomen. The present study was undertaken to investigate the effect of octreotide (OCT) administration on heme ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.11.012
更新日期：2006-06-01 00:00:00
abstract：:An identical CRF-related diuretic peptide (Musca-DP) was isolated and characterized from whole-body extracts of the house fly, Musca domestica, and stable fly, Stomoxys calcitrans. The peptide stimulates cyclic AMP production in Manduca sexta Malpighian tubules and increases the rate of fluid secretion by isolated Mus...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90059-0
更新日期：1994-01-01 00:00:00
abstract：:A non-specific lipid transfer peptide (nsLTP) with antimicrobial activity was isolated from the mung bean (Phaseolus mungo) seeds. The procedure entailed aqueous extraction, ion exchange chromatography on CM-Sephadex and high performance liquid chromatography (HPLC) on POROS-HS-20. The peptide exhibited a molecular ma...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.06.004
更新日期：2004-08-01 00:00:00
abstract：:This paper reviews aspects of our research, focusing on the role of the melanocortin system in the central regulation of feeding and energy balance, which was begun in 1997. It describes data from successive physiological studies, concerning the identity of the appetite-regulating melanocortin receptor, melanocortin-4...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2005.01.030
更新日期：2006-02-01 00:00:00
abstract：:Melanocortins (MCs) are multifunctional peptide hormones that regulate a diversity of physiological functions. MCs have been implicated in sexual function in animals. We document here that a MC analog, Melanotan II (MTII), can enhance sexual function in human males (erectile activity) and females (increased levels of ...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2005.01.023
更新日期：2005-10-01 00:00:00
abstract：:The involvement of the hypothalamic beta-endorphinergic system in behavioral processes has previously been studied in adult rats. In the present report, we studied the effects of undernutrition and of inhibitory avoidance training on the hypothalamic beta-endorphin-like immunoreactivity of 21-day-old and adult rats. R...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(88)90117-9
更新日期：1988-07-01 00:00:00
abstract：:Gastrin/CCK peptides in extracts from bovine and porcine pituitary have been characterized by Sephadex gel filtration, reverse phase liquid chromatography and a CCK radioimmunoassay (RIA) which detects both CCK and gastrin [4]. Porcine pituitary extracts contain a small amount of two peptides with chromatographic beha...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(82)90121-8
更新日期：1982-05-01 00:00:00
abstract：:Humanin (HN) and its analogues have been shown to protect cells against death induced by various Alzheimer's disease (AD) genes and amyloid-beta-peptides in vitro; the analogues [Gly(14)]-HN and colivelin have also been shown to be potent in reversing learning and memory impairment induced by scopolamine or quinuclidi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.06.019
更新日期：2008-11-01 00:00:00
abstract：:Crustacean hyperglycemic hormone (CHH) not only plays an important role in the modulation of hemolymph glucose level but also functions in other biological events including molting, reproduction and stress response. Of the six CHHs characterized in Marsupenaeus japonicus, an expression system for recombinant Pej-SGP-V...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.07.017
更新日期：2009-03-01 00:00:00
abstract：:The monoclonal antibody 2F5 recognizing the neutralizing epitope ELDKWA on the C-domain could neutralize 90% of the investigated HIV-1 isolates. Low levels of ELDKWA-epitope-specific antibodies were observed in HIV-1-infected individuals. To induce high levels of antibodies to ELDKW-epitope, C-domain peptide (P2) was ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00179-0
更新日期：2000-04-01 00:00:00
abstract：:A novel antimicrobial peptide, with molecular mass of 1602.0469Da, produced by Brevibacillus laterosporus strain A60 was isolated and purified from the soil of mango plants. The purification procedure consisted of ammonium sulfate precipitation, cation exchange chromatography on an HiTrap SP HP column, thin layer chro...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.01.001
更新日期：2012-02-01 00:00:00
abstract：:We show here that crotamine, a polypeptide from the South American rattlesnake venom with cell penetrating and selective anti-fungal and anti-tumoral properties, presents a potent anti-plasmodial activity in culture. Crotamine inhibits the development of the Plasmodium falciparum parasites in a dose-dependent manner [...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2016.01.013
更新日期：2016-04-01 00:00:00
abstract：:Amphibians exhibit various, characteristic adaptations related to their "incomplete" shift from the aquatic to the terrestrial habitat. In particular, the integument was subject to a number of specialized modifications during the evolution of these animals. In this review, we place special emphasis on endogenous host-...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2014.11.003
更新日期：2015-01-01 00:00:00
abstract：:Ad lib and intraoral intake tests can separate the effects of drugs on the appetitive and consummatory phases of ingestive behavior. Central angiotensin II increases ad lib intake from water bottles, but its effect on intraoral intake has not been examined. Rats with both lateral intracerebroventricular (i.c.v.) cannu...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00269-6
更新日期：1998-01-01 00:00:00
abstract：:Synthetic peptides containing a phosphorylation site for protein kinase CK2 were used to investigate their binding properties to other peptides/proteins. The aim of this work was to find an efficient procedure to search for these peptide/protein ligands. The goal was successfully achieved through screening of random p...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2003.12.017
更新日期：2004-02-01 00:00:00
abstract：:CART (cocaine- and amphetamine-regulated transcript) peptides are neuropeptides abundant in the central nervous system and periphery found to be involved in the regulation of food intake behavior and other physiological processes. Recently, we reported specific binding of (125)I-CART(61-102) to the rat adrenal pheochr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.07.022
更新日期：2007-10-01 00:00:00
abstract：:Trefoil factor family (TFF) 1, 2, and 3 is a mucin-associated protein involved in the maintenance of mucosal barrier and restitution of lining epithelial cells. In this study, the expression of TFF1, 2, and 3 and MUC mucins were examined immunohistochemically in hepatolithiasis and control livers. The expression of TF...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2003.12.023
更新日期：2004-05-01 00:00:00
abstract：:Calcification-associated peptide (CAP)-1 is considered to play an important role in calcification of the exoskeleton of the crayfish, Procambarus clarkii. In this study, in order to clarify the molecular mechanism of calcification, we constructed expression systems of recombinant molecules of CAP-1 and its related pep...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.12.005
更新日期：2007-03-01 00:00:00
abstract：:Kisspeptins are biologically active cleavage peptides of the KiSS-1 gene products with important roles in the suppression of tumor metastasis and in the reproduction. The aim of the present study is to clarify changes of the expression of kisspeptins and kisspeptin receptor in the kidney with and without chronic renal...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.07.001
更新日期：2010-10-01 00:00:00
abstract：:Imidazole-related dipeptides, such as carnosine and anserine, occur widely in skeletal muscles of jawed vertebrates. All of the known enzymes that catalyze the hydrolysis of these dipeptides belong to the M20A metallopeptidase subfamily; two secretory enzymes, serum carnosinase (EC 3.4.13.20) and anserinase (EC 3.4.13...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.01.008
更新日期：2011-04-01 00:00:00
