Expression of trefoil factor family 1, 2, and 3 peptide is augmented in hepatolithiasis.

abstract：:Incorporation of N-succinimidyl-3(4-hydroxyphenyl) propionate (Bolton-Hunter reagent) or its 125I-labeled derivative into peptides can be selectively directed towards either alpha- or epsilon-amine functions by modifying the pH of the reaction. Acylation of alpha-amino groups is favored at pH 6.5 whereas epsilon-amino...

journal_title：Peptides

authors： Gaudriault G,Vincent JP

更新日期：1992-11-01 00:00:00

abstract：:Nervous, endocrine, and immune systems share a large number of regulatory molecules including hormones and neuropeptides. Vasoactive intestinal peptide (VIP) plays an important role in a variety of immunological functions. In the present report, we sorted purified thymocytes of the four major thymic subsets defined by...

journal_title：Peptides

authors： Delgado M,Martínez C,Leceta J,Garrido E,Gomariz RP

更新日期：1996-01-01 00:00:00

abstract：:Substance P (SP) is known to be involved in processes related to learning and memory, fear, anxiety and stress. SP and NK1 receptors are localized in the hippocampus, a brain structure involved in learning and memory as well as emotional processes. As there is evidence for differential functions of the ventral (VH) an...

journal_title：Peptides

authors： Carvalho MC,Masson S,Brandão ML,de Souza Silva MA

更新日期：2008-07-01 00:00:00

abstract：:Acute treatment of rats with haloperidol results in a rapid and transient increase in striatal c-fos mRNA and Fos immunoreactivity. The induction of immediate early genes by haloperidol may be involved in the development of extrapyramidal side effects. L-Prolyl-L-leucyl-glycinamide (PLG, or MIF-1) has been observed to...

journal_title：Peptides

authors： Ott MC,Costain WJ,Mishra RK,Johnson RL

更新日期：2000-02-01 00:00:00

abstract：:Interdigestive migrating contractions (IMC) were analyzed for their occurrence interval, duration, migrating velocity, and frequently in long term records obtained by means of chronically implanted force transducers in the main stomach and the extrinsically denervated fundic pouches or in the intact jejunum and the ex...

journal_title：Peptides

authors： Itoh Z,Nakaya M,Suzuki T

更新日期：1981-01-01 00:00:00

abstract：:Kallikrein-related peptidases (KLKs) are a group of serine proteases, expressed in several tissues. Their activity is regulated by inhibitors including members of the serine protease of Kazal-type (SPINK) family. Recently, we discovered that SPINK6 is expressed in human skin and inhibits KLK5, KLK7, KLK14 but not KLK8...

journal_title：Peptides

authors： Kantyka T,Fischer J,Wu Z,Declercq W,Reiss K,Schröder JM,Meyer-Hoffert U

更新日期：2011-06-01 00:00:00

abstract：:Despite the high impact of the antimicrobial peptide hepcidin in iron homeostasis, the regulation of this hormone is still not completely understood. Studies concerning hepcidin regulation are performed at the mRNA level. For the first time we analyzed the regulation of hepcidin not only at mRNA, but also at protein l...

journal_title：Peptides

authors： Fein E,Merle U,Ehehalt R,Herrmann T,Kulaksiz H

更新日期：2007-05-01 00:00:00

abstract：:Quantitative receptor autoradiography was used to examine the binding of [125I]-human CGRP in the dorsal horn of the L4 spinal segment of rats with a chronic constriction injury (CCI) of the sciatic nerve or unilateral dorsal rhizotomies of spinal segments L1-L6. At the times selected for study, we found no change in ...

journal_title：Peptides

authors： Garry MG,Kajander KC,Bennett GJ,Seybold VS

更新日期：1991-11-01 00:00:00

abstract：:Neurotensin and somatostatin have both been shown to inhibit gastric acid secretion, but no interaction between these peptides has been demonstrated. To determine whether somatostatin might be a mediator of neurotensin's effect on pentagastrin-stimulated gastric acid secretion, we performed the following three experim...

journal_title：Peptides

authors： Hammer RA,Ochoa A,Fernandez C,Ertan A,Arimura A

更新日期：1992-11-01 00:00:00

abstract：:Chemerin is a novel peptide that was identified as a natural ligand for ChemR23. As it has been reported to be involved in the regulation of immune responses and adipogenesis, chemerin may have a variety of physiological functions. Chemerin is synthesized as a precursor (prochemerin) and is proteolytically activated a...

journal_title：Peptides

authors： Shimamura K,Matsuda M,Miyamoto Y,Yoshimoto R,Seo T,Tokita S

更新日期：2009-08-01 00:00:00

abstract：:Antibodies to the extreme C-terminal pentapeptide of procholecystokinin, YEYPS (in the single letter notation), have been used in radioimmunoassay and immunohistochemistry to characterize the material in rat intestine. There is a single major immunoreactive peptide in intestinal extracts that has the properties of the...

journal_title：Peptides

authors： Jonsson AC,Varro A,Dockray GJ

更新日期：1987-01-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) is a proglucagon-derived hormone with cellular protective actions. We hypothesized that GLP-1 would protect the endothelium from injury during inflammation. Our aims were to determine the: (1) effect of GLP-1 on basal microvascular permeability, (2) effect of GLP-1 on increased microvas...

journal_title：Peptides

authors： Dozier KC,Cureton EL,Kwan RO,Curran B,Sadjadi J,Victorino GP

更新日期：2009-09-01 00:00:00

abstract：:In the adrenal gland all components of the renin-angiotensin system (RAS) are expressed in both the adrenal cortex and the adrenal medulla. In this review evidence shall be presented that a local secretory RAS exists in the adrenal cortex that stimulates aldosterone production and serves as an amplification system for...

journal_title：Peptides

authors： Peters J

更新日期：2012-04-01 00:00:00

abstract：:The gastrin-releasing peptide receptor (GRPR) has been implicated in the modulation of emotionally-motivated memory. In the present study, we investigated the role of the GRPR on non-emotional, non-associative memory, and anxiety. Adult male Wistar rats were given a systemic injection of the GRPR antagonist [D-Tpi6, L...

journal_title：Peptides

authors： Martins MR,Reinke A,Valvassori SS,Machado RA,Quevedo J,Schwartsmann G,Roesler R

更新日期：2005-12-01 00:00:00

abstract：:A new series of analogues of the potent opiate-like peptides dermorphins (mainly tetra- and pentapeptides) were synthesized in order to better evaluate the structure-activity relationships. Relative potencies were referred to dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), the prototype of this class of frog skin pe...

journal_title：Peptides

authors： Melchiorri P,Erspamer GF,Erspamer V,Guglietta A,De Castiglione R,Faoro F,Perseo G,Piani S,Santangelo F

更新日期：1982-09-01 00:00:00

abstract：:The distribution of neurokinin B (NKB) was determined by immunocytochemistry with antisera directed toward its amino terminus. Immunoreactive perikarya were detected in the main and accessory olfactory bulbs, cortical regions, the olfactory tubercle, the bed nucleus of the stria terminalis, the diagonal band of Broca,...

journal_title：Peptides

authors： Merchenthaler I,Maderdrut JL,O'Harte F,Conlon JM

更新日期：1992-07-01 00:00:00

abstract：:The role of hippocampal dynorphin A (1-8) (Dyn A (1-8)) and kappa opioid receptors was investigated in the isolation-induced hypertensive rat (IHR). Male Sprague Dawley rats were either isolated (1 per cage) or grouped (3 per cage) for 7 days. Isolated rats exhibited increased blood pressure (systolic blood pressure 1...

journal_title：Peptides

authors： Wright RC,McConnaughey MM,Ingenito AJ

更新日期：2000-12-01 00:00:00

abstract：:Recent studies have provided evidence for the dense localization of atrial natriuretic factor (ANF) in the anteroventral third ventricle (AV3V) region of the rat brain. This area is currently thought to be involved in the regulation of blood pressure and fluid and electrolyte balance. To investigate whether ANF may pl...

journal_title：Peptides

authors： Sills MA,Nguyen KQ,Jacobowitz DM

更新日期：1985-11-01 00:00:00

abstract：:New dual immunocytochemical staining procedures were used in the same tissue section to elucidate the distribution and co-existence of CRF and vasopressin in parvocellular neuronal perikarya in the paraventricular nucleus (PVN) of rat hypothalamus. CRF immunostained cells were for the most part concentrated in the med...

journal_title：Peptides

authors： Piekut DT,Joseph SA

更新日期：1986-09-01 00:00:00

abstract：:Peptides are important regulators of growth and cellular functions not only in normal tissue but also in tumors. So they are becoming radioligands of increasing interest in nuclear oncology for targeted tumor diagnosis and therapy. So development of new peptide radiopharmaceuticals is becoming one of the most importan...

journal_title：Peptides

authors： Chandra S,De K,Ganguly S,Sarkar B,Misra M

更新日期：2009-12-01 00:00:00

abstract：:Using autoradiographic method and 125I-Tyro rat CGRP as a ligand, receptor binding sites were demonstrated in the rat central nervous system. Saturation studies and Scatchard analysis of CGRP-binding to slide mounted tissue sections containing primarily cerebellum showed a single class of receptors with a dissociation...

journal_title：Peptides

authors： Skofitsch G,Jacobowitz DM

更新日期：1985-09-01 00:00:00

abstract：:It is known that painful tissue injury evokes an increase in dynorphin in spinal neurons. It is not known, however, whether dynorphinergic systems respond similarly to the pain that accompanies peripheral neuropathy. Radioimmunoassays and immunocytochemistry were used to evaluate changes in dynorphin A(1-8) in the spi...

journal_title：Peptides

authors： Kajander KC,Sahara Y,Iadarola MJ,Bennett GJ

更新日期：1990-07-01 00:00:00

abstract：:The cDNAs encoding the preprohormones of the regulatory peptides cholecystokinin (CCK) and the related gastrin have been identified in a number of vertebrate species. However, from birds only chicken preprogastrin is known. In the present study preproCCK cDNA was identified in two species of birds, ostrich and chicken...

journal_title：Peptides

authors： Jønson L,Schoeman N,Saayman H,Naudé R,Jensen H,Johnsen AH

更新日期：2000-09-01 00:00:00

abstract：:To characterize the endothelin (ET) receptor that mediates the contraction induced by ET-1 in the porcine myometrium, we carried out a contraction study, radioligand binding study and molecular study (reverse transcription polymerase chain reaction) for detection of ET receptor-coding genes (mRNA). ET-1 (1 nM-1 microM...

journal_title：Peptides

authors： Isaka M,Takaoka K,Yamada Y,Abe Y,Kitazawa T,Taneike T

更新日期：2000-04-01 00:00:00

abstract：:Peptides of the short neuropeptide F (sNPF) family have been shown to modulate feeding behavior in a wide variety of insect species. While these peptides stimulate feeding and food-searching behavior in Drosophila melanogaster and Apis mellifera, an opposite effect has recently been demonstrated in the desert locust, ...

journal_title：Peptides

authors： Dillen S,Verdonck R,Zels S,Van Wielendaele P,Vanden Broeck J

更新日期：2014-03-01 00:00:00

abstract：:It is well known that neuropeptide Y (NPY) and gamma-aminobutyric acid (GABA) exert antiepileptic effects in animal models. It has recently been shown that ghrelin neurons increase the activities of GABA and NPY in the brain. Therefore it can be said that ghrelin is an antiepileptic agent. In this study we aimed to in...

journal_title：Peptides

authors： Obay BD,Tasdemir E,Tümer C,Bilgin HM,Sermet A

更新日期：2007-06-01 00:00:00

abstract：:The effects of third ventricular (IVT) injection of 25 micrograms of bradykinin (BK) upon plasma levels of LH, FSH, TSH, GH and prolactin were investigated in conscious ovariectomized female rats bearing indwelling jugular cannulae. Some animals were pretreated with bradykinin potentiating factor (BPF). Intravenous ad...

journal_title：Peptides

authors： Steele MK,Negro-Vilar A,McCann SM

更新日期：1980-10-01 00:00:00

abstract：:The present studies were undertaken to better characterize the pharmacological properties of oxytocin receptors (OTRs) of the porcine kidney cell line, LLC-PK1, in their natural membranous environment and after solubilization. In intact membranes, binding of a selective radioligand was rapid, reversible, saturable, an...

journal_title：Peptides

authors： Flanagan-Cato LM,Moga CN,Fluharty SJ

更新日期：1996-01-01 00:00:00

abstract：:PACAP-27 and PACAP-38 are the exclusive physiological ligands for the mammalian PAC1 receptor. The role of C-terminal amidation of these ligands at that receptor was examined in neuroendocrine cells expressing the PAC1 receptor endogenously and in non-neuroendocrine cells in which the human and rat PAC1 receptors were...

journal_title：Peptides

authors： Emery AC,Alvarez RA,Abboud P,Xu W,Westover CD,Eiden MV,Eiden LE

更新日期：2016-05-01 00:00:00

abstract：:Opioid-like immunoreactive material was extracted from the pituitary and brain of the Spiny Dogfish Shark Squalus acanthias. The immunoreactive material in the pituitary extracts was purified to apparent homogeneity by reverse phase high performance liquid chromatography and subsequently characterized by amino acid an...

journal_title：Peptides

authors： Lorenz RG,Tyler AN,Faull KF,Makk G,Barchas JD,Evans CJ

更新日期：1986-01-01 00:00:00