Dynorphin increases in the dorsal spinal cord in rats with a painful peripheral neuropathy.

abstract：:Two peptides, with a molecular mass of about 11 kDa and an N-terminal sequence abundant in arginine and glutamine residues, were isolated from wax gourd seeds. The isolation protocol included affinity chromatography on Affi-gel blue gel, ion-exchange chromatography on Mono-S and gel filtration on Superdex 75. The pept...

journal_title：Peptides

authors： Ng TB,Parkash A,Tso WW

更新日期：2003-01-01 00:00:00

abstract：:Atrial dipeptidyl carboxyhydrolase readily converts one atrial natriuretic peptide, atriopeptin II (Ser103-Arg125 peptide), to another, atriopeptin I (Ser103-Ser123 peptide), by selective removal of the C-terminal dipeptide, Phe-Arg. The atrial peptides possess natriuretic, diuretic, smooth muscle relaxant, and cardio...

journal_title：Peptides

authors： Soler DF,Harris RB

更新日期：1989-01-01 00:00:00

abstract：:Locust abdominal ganglia are shown to colocalize Locusta-diuretic peptide-, leucokinin I-, and lysine vasopressin-like immunoreactivity in posterior lateral neurosecretory cells. Extracts of abdominal ganglia were partially purified by RP-HPLC then dot immunoassay screened with the same antisera used for immunocytoche...

journal_title：Peptides

authors： Thompson KS,Rayne RC,Gibbon CR,May ST,Patel M,Coast GM,Bacon JP

更新日期：1995-01-01 00:00:00

abstract：:Motilin is a regulatory polypeptide of 22 amino acid residues and orginates in motilin cells scattered in the duodenal epithelium of most mammals and chickens. Motilin is released into the general circulation at about 100-min intervals during the interdigestive state and is the most important factor in controlling the...

journal_title：Peptides

authors： Itoh Z

更新日期：1997-01-01 00:00:00

abstract：:N-hydroxysuccinimide (NHS) esters of biotin are reported to react specifically with amino groups of peptides and proteins. However, we have found that these reagents can readily acylate other functional groups in specific peptide sequences under relatively mild conditions. We have extended our inquiry of sequence-depe...

journal_title：Peptides

authors： Miller BT,Collins TJ,Rogers ME,Kurosky A

更新日期：1997-01-01 00:00:00

abstract：:We compared the effects of three micro-(DAMGO, DALDA, TNPO) and three delta-(DPDPE, DELT, SNC-80) opioid agonists on arterial blood gas after IV administration in awake sheep. None of the mu agonists altered pO2, pCO2 or pH. All three mu agonists decreased pO2 increased pCO2 and decreased pO2, and this effect was not ...

journal_title：Peptides

authors： Szeto HH,Soong Y,Wu D,Olariu N,Kett A,Kim H,Clapp JF

更新日期：1999-01-01 00:00:00

abstract：:Peptides are an important class of molecules with diverse biological activities. Many endogenous peptides, especially neuropeptides and peptide hormones, play critical roles in development and regulating homeostasis. Furthermore, as drug candidates their high receptor selectivity and potent binding leads to reduced of...

journal_title：Peptides

authors： Apostol CR,Hay M,Polt R

更新日期：2020-09-01 00:00:00

abstract：:Spinal cords of rats, cats and monkeys were transected; the animals were perfused at varying times. Other rats were injected with morphine and perfused 10 days later. Immunocytochemistry shows substance P (SP) present in control animals primarily in the substantia gelatinosa (SG) of the dorsal horn of the spinal cord....

journal_title：Peptides

authors： Naftchi NE,Abrahams SJ,St Paul HM,Vacca LL

更新日期：1981-01-01 00:00:00

abstract：:The cell adhesion molecule, N-cadherin plays a pivotal role in many biological and disease processes. Drugs that modulate N-cadherin function should therefore be useful therapeutic agents. We have used phage display technology to identify amino acid sequences capable of binding to N-cadherin. All of these sequences ha...

journal_title：Peptides

authors： Devemy E,Blaschuk OW

更新日期：2008-11-01 00:00:00

abstract：:Originally characterized in terms of its gastric acid inhibitory properties, GIP (gastric inhibitory polypeptide) expressed in the upper small intestine, was subsequently shown to exert strong glucose-dependent insulin-releasing properties. This action is generally attributed to GIP(1-42) and, so far, no evidence for ...

journal_title：Peptides

authors： Fehmann HC,Göke B

更新日期：1995-01-01 00:00:00

abstract：:Staphylococcal enterotoxins (SEs) are emetic toxins that cause food poisoning. SEs also function as powerful pyrogenic toxin superantigens that stimulate non-specific T-cell proliferation. Together with the hemolysins, SEs have been largely implicated as virulence factors in multiple infection models. Recent biochemic...

journal_title：Peptides

authors： Vieira-da-Motta O,Ribeiro PD,Dias da Silva W,Medina-Acosta E

更新日期：2001-10-01 00:00:00

abstract：:Because plasma levels of protein C (PC) or activated protein C (APC) are altered in certain diseases associated with vascular dysfunction, and APC has therapeutic potential in preventing microvascular coagulation in severe sepsis, potential vascular effects of PC and APC were compared to those of the vasoactive peptid...

journal_title：Peptides

authors： Bhattacharya A,Grinnell BW,Cohen ML

更新日期：2000-08-01 00:00:00

abstract：:In an attempt to establish the role of F8Famide in opioid activity modulation, we examined the effects of intracerebroventricular administration of the F8Famide analogs (1DME)Y8Fa and (3D)Y8Fa on intestinal transit in mice. (1DME)Y8Fa (0.88 to 22 nmol) inhibited intestinal transit as did F8Famide and morphine. An IP i...

journal_title：Peptides

authors： Gicquel S,Fioramonti J,Bueno L,Zajac JM

更新日期：1993-07-01 00:00:00

abstract：:The biological activities of alpha-MSH des-acetyl MSH, gamma-MSH and LPH37-58 were compared using the Anolis rate method of bioassay. Dose-response data showed LPH37-58 to be equipotent with alpha-MSH, but des-acetyl MSH and gamma-MSH were found to be much less active. The effect of LPH37-58 was additive to that of al...

journal_title：Peptides

authors： McCormack AM,Carter RJ,Thody AJ,Shuster S

更新日期：1982-01-01 00:00:00

abstract：:Somatostatin has been proposed as a regulatory peptide of nutrient entry and fuel homeostasis because of its ability to inhibit the release of substances involved in food digestion and metabolism. The aim of the study was to evaluate the somatostatin response to a test meal in type I diabetics at the clinical onset of...

journal_title：Peptides

authors： Uccioli L,Ghirlanda G,Cotroneo P,Bianchini G,Manto A,Solini A,Annese V,Greco AV

更新日期：1986-01-01 00:00:00

abstract：:Immunohistochemical studies were conducted on rat brainstem using a specific polyclonal antiserum against the COOH-terminal (25-37) of human amylin. Amylin-immunoreactive cell bodies were observed in the vestibular, cochlear, trapezoid, and inner cerebellar nuclei and in the mesencephalic nucleus of trigeminal nerve. ...

journal_title：Peptides

authors： D'Este L,Casini A,Wimalawansa SJ,Renda TG

更新日期：2000-11-01 00:00:00

abstract：:A newly developed system of isolated rat colonic epithelial cells was utilized for a comprehensive study of protein synthesis influenced by gastrin. We found that synthetic human gastrin (0.01-100 nM) increased the incorporation of [35S]methionine into proteins within 2 hours. Peak incorporation was observed with 10 n...

journal_title：Peptides

authors： Yassin RR,Clearfield HR,Katz SM,Murthy SN

更新日期：1991-01-01 00:00:00

abstract：:Irisin was first identified in skeletal muscle cells, but its precise location has not yet been demonstrated, and there is limited information about irisin protein in other human and rat tissues. The present immunohistochemical study was undertaken to screen skeletal muscle and other tissues for irisin immunoreactivit...

journal_title：Peptides

authors： Aydin S,Kuloglu T,Aydin S,Kalayci M,Yilmaz M,Cakmak T,Albayrak S,Gungor S,Colakoglu N,Ozercan IH

更新日期：2014-11-01 00:00:00

abstract：:Defense peptides play a crucial role in insect innate immunity against invading pathogens. From the hemolymph of immune-challenged greater wax moth, Galleria mellonella (Gm) larvae, eight peptides were isolated and characterized. Purified Gm peptides differ considerably in amino acid sequences, isoelectric point value...

journal_title：Peptides

authors： Cytryńska M,Mak P,Zdybicka-Barabas A,Suder P,Jakubowicz T

更新日期：2007-03-01 00:00:00

abstract：:We investigated the plasma concentration of ghrelin peptide during pregnancy and lactation in rats. Plasma ghrelin levels on days 10 and 15 of pregnancy were significantly lower than those of the non-pregnant rats. Thereafter, the plasma ghrelin levels on day 20 of pregnancy sharply increased to levels comparable with...

journal_title：Peptides

authors： Shibata K,Hosoda H,Kojima M,Kangawa K,Makino Y,Makino I,Kawarabayashi T,Futagami K,Gomita Y

更新日期：2004-02-01 00:00:00

abstract：:The aim of the present study was to evaluate in hypothalamus and hindbrain of rainbow trout in vitro the effect of leptin treatment on glucosensing capacity and the expression of orexigenic and anorexigenic peptides involved in the control of food intake. In a first experiment, the response of parameters involved in g...

journal_title：Peptides

authors： Aguilar AJ,Conde-Sieira M,López-Patiño MA,Míguez JM,Soengas JL

更新日期：2011-02-01 00:00:00

abstract：:CGRP has potent cardiovascular effects but its role in heart failure is unclear. Effects of CGRP on calcium concentrations in fresh adult rat cardiomyocytes, cultured adult cardiomyocytes and neonatal cardiomyocytes were determined by real time fluorescence spectrophotometry. Treatment of cultured adult cardiomyocytes...

journal_title：Peptides

authors： Schiess MC,Poindexter BJ,Brown BS,Bick RJ

更新日期：2005-03-01 00:00:00

abstract：:The insect kinin neuropeptides have been implicated in the regulation of water balance, digestive organ contraction, and energy mobilization in a number of insect species. A previous solution conformation study of an active, restricted-conformation cyclic analog, identified two possible turn conformations as the likel...

journal_title：Peptides

authors： Nachman RJ,Zabrocki J,Olczak J,Williams HJ,Moyna G,Ian Scott A,Coast GM

更新日期：2002-04-01 00:00:00

abstract：:A novel 6.6 kDa antifungal peptide (NFAP) from the culture supernatant of the mold, Neosartorya fischeri (anamorf: Aspergillus fischerianus), and its encoding gene were isolated in this study. NFAP is a small, basic and cysteine-rich protein consisting of 57 amino acid residues. It shows 37.9-50% homology to similar p...

journal_title：Peptides

authors： Kovács L,Virágh M,Takó M,Papp T,Vágvölgyi C,Galgóczy L

更新日期：2011-08-01 00:00:00

abstract：:A new series of analogues of the potent opiate-like peptides dermorphins (mainly tetra- and pentapeptides) were synthesized in order to better evaluate the structure-activity relationships. Relative potencies were referred to dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), the prototype of this class of frog skin pe...

journal_title：Peptides

authors： Melchiorri P,Erspamer GF,Erspamer V,Guglietta A,De Castiglione R,Faoro F,Perseo G,Piani S,Santangelo F

更新日期：1982-09-01 00:00:00

abstract：:This study presents the binding and functional properties of the mouse NPFF(2) (mNPFF(2)) receptor, in comparison with its human counterpart (hNPFF(2)). Binding experiments were performed by using the NPFF(2) selective radioligand [(3)H]-EYF in membranes from CHO cells transfected with mouse and human NPFF(2) receptor...

journal_title：Peptides

authors： Talmont F,Moulédous L,Piedra-Garcia L,Schmitt M,Bihel F,Bourguignon JJ,Zajac JM,Mollereau C

更新日期：2010-02-01 00:00:00

abstract：:The expression of the relaxin-3 gene, detected as a new member of the insulin superfamily using human genomic databases, is abundantly present in the brain and testis. Intracerebroventricularly (icv) administered relaxin-3 stimulates food intake. Icv administered relaxin (identical to relaxin-2 in humans) affects the ...

journal_title：Peptides

authors： Otsubo H,Onaka T,Suzuki H,Katoh A,Ohbuchi T,Todoroki M,Kobayashi M,Fujihara H,Yokoyama T,Matsumoto T,Ueta Y

更新日期：2010-06-01 00:00:00

abstract：:Experiments characterized the behavioral effects of bombesin (BN) administered systemically (1-8 micrograms/kg; IP) or centrally at the nucleus tractus solitarius (NTS) and the nucleus accumbens (NA) (0.0001-1.0 microgram/0.5 microliter). The role of dopaminergic system(s) in the mediation of BN-induced behavioral eff...

journal_title：Peptides

authors： Johnston SA,Merali Z

更新日期：1988-01-01 00:00:00

abstract：:A linear peptide containing two reduced cysteine residues can be rapidly converted to its oxidized cyclic form containing an intramolecular disulfide bond by adding an excess of 2,2'-bispyridyl disulfide (2,2'-dipyridyl disulfide or 2,2'-dithiodipyridine) to conventional buffer solutions. The reactants and products ar...

journal_title：Peptides

authors： Maruyama K,Nagasawa H,Suzuki A

更新日期：1999-01-01 00:00:00

abstract：:Tight junctions (TJ) control paracellular permeability and apical-basolateral polarity of epithelial cells. Dysregulated permeability is associated with pathological conditions, such as celiac disease and inflammatory bowel disease. TJ formation is dependent on E-cadherin-mediated cell-cell adhesion and actin rearrang...

journal_title：Peptides

authors： Gopalakrishnan S,Tripathi A,Tamiz AP,Alkan SS,Pandey NB

更新日期：2012-05-01 00:00:00