Synthetic peptides related to the dermorphins. II. Synthesis and biological activities of new analogues.

abstract：:Intestinal levels of immunoreactive neurotensin (iNT) and neuromedin N (iNMN), as well as mRNA for the NT/NMN precursor, were elevated during the suckling period in rats. While transient expression of NT/NMN was observed at 1-5 days of age in the proximal small intestine and colon, NT/NMN levels in the ileum increased...

journal_title：Peptides

authors： Muraki K,Mitra SP,Dobner PR,Carraway RE

更新日期：1993-11-01 00:00:00

abstract：:Copeptin can reflect individual's stress state and are correlated with poor outcome of critical illness. The occurrence of postoperative delirium (POD) and cognitive dysfunction (POCD) is associated with worse outcome after coronary artery bypass graft (CABG) surgery. The present study aimed to investigate the ability...

journal_title：Peptides

authors： Dong S,Li CL,Liang WD,Chen MH,Bi YT,Li XW

更新日期：2014-09-01 00:00:00

abstract：:The secretin receptor is a member of a large family of G-protein-coupled receptors that recognize polypeptide hormone and/or neuropeptides. Charged, conserved residues might play a key role in their function, either by interacting with the ligand or by stabilizing the receptor structure. Of the four charged amino acid...

journal_title：Peptides

authors： Di Paolo E,Vilardaga JP,Petry H,Moguilevsky N,Bollen A,Robberecht P,Waelbroeck M

更新日期：1999-01-01 00:00:00

abstract：:Arginine-vasopressin (AVP) is a hypothalamic hormone that, like CRH, stimulates the pituitary release of ACTH, thereby activating adrenal glucocorticoid secretion. Evidence indicates that rat adrenal medulla contains a CRH-ACTH system duplicating that existing at the hypothalamo-pituitary level and involved in the par...

journal_title：Peptides

authors： Mazzocchi G,Malendowicz LK,Rebuffat P,Tortorella C,Nussdorfer GG

更新日期：1997-01-01 00:00:00

abstract：:Previous reports have demonstrated that systemic injection of cholecystokinin (CCK) in rats produces dose-related decreases in food intake, increases in neurohypophyseal secretion of oxytocin (OT), and decreases in gastric emptying. The present studies determined whether systemic injection of bombesin (BBS), another p...

journal_title：Peptides

authors： Verbalis JG,McCann MJ,Stricker EM

更新日期：1988-11-01 00:00:00

abstract：:We are interested in the presence and function in insects of neuropeptides related to the vertebrate tachykinins. Hence, we have used antisera raised against the tachykinins substance P and kassinin, and against the insect neuropeptide leucokinin I, for localization studies and immunochemical analysis of related pepti...

journal_title：Peptides

authors： Lundquist CT,Brodin E,Muren JE,Nässel DR

更新日期：1993-07-01 00:00:00

abstract：:Pheromone biosynthesis activating neuropeptide (PBAN) produced in the subesophageal ganglion stimulates pheromone production in the pheromone gland. A cDNA isolated from female adult heads of the diamondback moth (Plutella xylostella (L.)) encodes 193 amino acids including PBAN, designated as Plx-PBAN, and four other ...

journal_title：Peptides

authors： Lee DW,Boo KS

更新日期：2005-12-01 00:00:00

abstract：:The endangered anuran species, Odorrana ishikawae, is endemic to only two small Japanese Islands, Amami and Okinawa. To assess the innate immune system in this frog, we investigated antimicrobial peptides in the skin using artificially bred animals. Nine novel antimicrobial peptides containing the C-terminal cyclic he...

journal_title：Peptides

authors： Iwakoshi-Ukena E,Ukena K,Okimoto A,Soga M,Okada G,Sano N,Fujii T,Sugawara Y,Sumida M

更新日期：2011-04-01 00:00:00

abstract：:Two food-derived ACE inhibitory peptides, Ile-Pro-Pro (IPP) and Leu-Lys-Pro (LKP), may have potential as alternative treatments for treatment of mild- or pre-hypertension. Lack of stability to secretory and intracellular peptidases and poor permeability across intestinal epithelia are typical limiting factors of oral ...

journal_title：Peptides

authors： Gleeson JP,Heade J,Ryan SM,Brayden DJ

更新日期：2015-09-01 00:00:00

abstract：:The purpose of this study was to investigate in the aged animal the functional interaction between cholecystokinin (CCK) and amino acid neurotransmitter activity in the frontal cortex, a structure of importance in age-related disabilities. Guide cannula for repeated push-pull perfusion were implanted bilaterally in th...

journal_title：Peptides

authors： Peinado JM,Myers RD

更新日期：1988-05-01 00:00:00

abstract：:A novel peptide hormone, atrial natriuretic factor (ANF), was recently isolated and characterized in mammalian atria. This hormone has potent natriuretic diuretic and vasorelaxant activities. Since ANF bioactivity was initially found in atria but not in ventricles, it was assumed that the ANF gene is specifically expr...

journal_title：Peptides

authors： Nemer M,Lavigne JP,Drouin J,Thibault G,Gannon M,Antakly T

更新日期：1986-11-01 00:00:00

abstract：:Treatment of cultured rat hepatocytes with cyclosporin A (0.01-1 microM) for 24, 48, or 72 h in the presence of insulin and epidermal growth factor induced an inhibition on cell proliferation in a time- and concentration-dependent manner, with an IC50 = 0.05 microM CsA corresponding to 48-h treatment. The inhibitory e...

journal_title：Peptides

authors： Rodriguez-Henche N,Román ID,Fueyo J,Menor C,Zueco JA,Prieto JC,Guijarro LG

更新日期：1998-01-01 00:00:00

abstract：:Many neuroendocrine peptides that are distributed in amphibian gastrointestinal tract and central nervous system are also found in amphibian skins, and these peptides are classified into skin-gut-brain triangle peptides, such as bombesins, gastrin-releasing peptides. Cholecystokinins (CCKs) are neuroendocrine peptides...

journal_title：Peptides

authors： Liu X,Wang Y,Cheng L,Song Y,Lai R

更新日期：2007-08-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) has a similar structure to that of vasoactive intestinal peptide (VIP) and both the polypeptides belong to the same molecular group, the secretin-glucagon superfamily. PACAP and VIP have possible potency as hypothalamic factors mediating the release of pituita...

journal_title：Peptides

authors： Matsuda K,Maruyama K,Nakamachi T,Miura T,Uchiyama M,Shioda S

更新日期：2005-09-01 00:00:00

abstract：:Legionella pneumophila, the causative agent of Legionnaires' disease, is a waterborne bacteria. It can multiply in man-made water systems and infect people who inhale contaminated droplets. We have previously reported a Staphylococcus warneri strain that display an anti-Legionella activity. In this work, we characteri...

journal_title：Peptides

authors： Verdon J,Berjeaud JM,Lacombe C,Héchard Y

更新日期：2008-06-01 00:00:00

abstract：:We show here that crotamine, a polypeptide from the South American rattlesnake venom with cell penetrating and selective anti-fungal and anti-tumoral properties, presents a potent anti-plasmodial activity in culture. Crotamine inhibits the development of the Plasmodium falciparum parasites in a dose-dependent manner [...

journal_title：Peptides

authors： El Chamy Maluf S,Dal Mas C,Oliveira EB,Melo PM,Carmona AK,Gazarini ML,Hayashi MA

更新日期：2016-04-01 00:00:00

abstract：:The distributions of neuropeptides in paraffin-embedded tissue sections (PETS) of the eyestalk, brain, and thoracic ganglia of the shrimp Penaeus monodon were visualized by imaging mass spectrometry (IMS). Peptide signals were obtained from PETS without affecting morphological features. Twenty-nine neuropeptides compr...

journal_title：Peptides

authors： Chansela P,Goto-Inoue N,Zaima N,Sroyraya M,Sobhon P,Setou M

更新日期：2012-03-01 00:00:00

abstract：:Because plasma levels of protein C (PC) or activated protein C (APC) are altered in certain diseases associated with vascular dysfunction, and APC has therapeutic potential in preventing microvascular coagulation in severe sepsis, potential vascular effects of PC and APC were compared to those of the vasoactive peptid...

journal_title：Peptides

authors： Bhattacharya A,Grinnell BW,Cohen ML

更新日期：2000-08-01 00:00:00

abstract：:The cDNAs encoding the preprohormones of the regulatory peptides cholecystokinin (CCK) and the related gastrin have been identified in a number of vertebrate species. However, from birds only chicken preprogastrin is known. In the present study preproCCK cDNA was identified in two species of birds, ostrich and chicken...

journal_title：Peptides

authors： Jønson L,Schoeman N,Saayman H,Naudé R,Jensen H,Johnsen AH

更新日期：2000-09-01 00:00:00

abstract：:Adrenocorticotropic Hormone (ACTH), Melanocyte-Stimulating Hormone (MSH), and related peptides have been shown to have several neurogenic effects: alteration of cerebral protein synthesis, RNA synthesis, protein phosphorylation, and neurotransmitter turnover. Furthermore, there appears to be an ACTH containing circuit...

journal_title：Peptides

authors： Beckwith BE,Sandman CA

更新日期：1982-05-01 00:00:00

abstract：:We demonstrated previously that hippocampal dentate gyrus neurons were sensitive to angiotensin II (AII) and recently discovered that AII applied directly to the dentate gyrus inhibited granule cell long-term potentiation induction and that the inhibition is mediated by the AT1 receptor and can be blocked by losartan,...

journal_title：Peptides

authors： Lee EH,Ma YL,Wayner MJ,Armstrong DL

更新日期：1995-01-01 00:00:00

abstract：:Originally characterized in terms of its gastric acid inhibitory properties, GIP (gastric inhibitory polypeptide) expressed in the upper small intestine, was subsequently shown to exert strong glucose-dependent insulin-releasing properties. This action is generally attributed to GIP(1-42) and, so far, no evidence for ...

journal_title：Peptides

authors： Fehmann HC,Göke B

更新日期：1995-01-01 00:00:00

abstract：:As a novel vasoactive peptide, plasma coupling factor 6 (CF6) was shown to be elevated in patients with diabetes mellitus, yet the mechanism involved is unknown. We studied CF6 protein release and its potential mechanism in human umbilical vein endothelial cells (HUVECs) incubated with high glucose levels. High glucos...

journal_title：Peptides

authors： Li X,Xing S,Zhang L,Xing Q,Yan S,Dai H,You S,Pang Y,Tang C

更新日期：2007-03-01 00:00:00

abstract：:Mustard oil, which stimulates small diameter afferents, was used to evoke the expression of the oncogene c-fos in the lumbar spinal cord. C-fos-like immunoreactivity was concentrated in, but not limited to, neuronal nuclei of laminae I and II of the lumbar dorsal horn. Double-label immunocytochemistry was used to dete...

journal_title：Peptides

authors： Pretel S,Piekut DT

更新日期：1991-11-01 00:00:00

abstract：:The distribution of neurokinin B (NKB) was determined by immunocytochemistry with antisera directed toward its amino terminus. Immunoreactive perikarya were detected in the main and accessory olfactory bulbs, cortical regions, the olfactory tubercle, the bed nucleus of the stria terminalis, the diagonal band of Broca,...

journal_title：Peptides

authors： Merchenthaler I,Maderdrut JL,O'Harte F,Conlon JM

更新日期：1992-07-01 00:00:00

abstract：:Cholecystokinin (CCK) is widely distributed in the brain and is known to affect behavioral and physiological functions including anxiety and pain. The expression of CCK has been shown to be regulated by estrogen and to vary during the estrous cycle in rat brain. In the present study CCK was determined in plasma from 2...

journal_title：Peptides

authors： Lundberg K,Hilke S,Nordin C,Theodorsson E,Josefsson A

更新日期：2010-08-01 00:00:00

abstract：:The presence of immunoreactive porcine brain natriuretic peptide in rat tissues was studied with a specific radioimmunoassay for porcine brain natriuretic peptide-26. The cross-reactivity of the antiserum used was less than 0.001% with rat atrial natriuretic peptide, rat brain natriuretic peptide-32 and rat brain natr...

journal_title：Peptides

authors： Sone M,Totsune K,Takahashi K,Ohneda M,Itoi K,Murakami O,Yoshinaga K,Mouri T

更新日期：1991-11-01 00:00:00

abstract：:Opiate binding sites in five brain regions were labeled with the mu and delta markers, 3H-morphine and 3H-[D-Ala2,D-leu5]enkephalin, respectively. The highest densities of both 3H-morphine and 3H-DADLE labeled sites are found in striatum and frontal cortex. Hypothalamus and midbrain contain predominantly 3H-morphine l...

journal_title：Peptides

authors： Hewlett WA,Barchas JD

更新日期：1983-11-01 00:00:00

abstract：:Spasmolytic polypeptide (SP) and intestinal trefoil factor (ITF) are trefoil peptides expressed by gut mucus cells. Using specific antisera we have quantified and characterized the molecular forms and distribution of these peptides in the rat gut. SP predominates in the gastric antrum as a 12 kDa form. ITF (7 kDa) is ...

journal_title：Peptides

authors： Taupin DR,Pang KC,Green SP,Giraud AS

更新日期：1995-01-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) is increasingly expressed on airway and inhibits pulmonary arterial remodeling. However, the role of ANP in remodeling of respiratory system is still unclear. The role of ANP on airway remodeling and the possible mechanism was explored in this study. Both human bronchial epithelial 16H...

journal_title：Peptides

authors： Chu S,Zhang X,Sun Y,Yu Y,Liang Y,Jiang M,Huang J,Ma L

更新日期：2017-04-01 00:00:00