当前位置： SCI文献检索 > PEPTIDES期刊下所有文献 > Cortical amino acid neurotransmitter release is altered by CCK perfused in frontal region of unrestrained aged rats.

Cortical amino acid neurotransmitter release is altered by CCK perfused in frontal region of unrestrained aged rats.

Abstract：

:The purpose of this study was to investigate in the aged animal the functional interaction between cholecystokinin (CCK) and amino acid neurotransmitter activity in the frontal cortex, a structure of importance in age-related disabilities. Guide cannula for repeated push-pull perfusion were implanted bilaterally in the superficial frontal cortex of male Sprague-Dawley rats. Two groups of animals were selected on the basis of their age at the time of stereotaxic surgery: 90 days and two years. Following post-operative recovery, an artificial CSF solution was perfused repeatedly within the cortex of each animal for a 5.0 min interval. The rate of perfusion was 25 microliters/min and a 5.0 min period elapsed between the collection of each sample of perfusate. After the initial control perfusions, CCK octapeptide was incorporated in a concentration of 6.0 or 18.0 ng/microliter in the CSF and perfused for 5.0 min under identical conditions. Each sample of perfusate was assayed by high performance liquid chromatography with electrochemical detection (HPLC-EC) for its content of glutamate (Glu), aspartate (Asp), glutamine (Gln), glycine (Gly), taurine (Tau) and gamma-amino-butyric acid (GABA) with homoserine used as an internal standard. Although CCK in the lower 6.0 ng/microliter concentration failed to alter significantly the profile of amino acids in the frontal cortex, the higher 18.0 ng/microliter solution of CCK enhanced the efflux of Glu as well as Asp, but only in the aged rats. Both concentrations of CCK tended also to augment the release of Gln in the older animals but these changes were not statistically significant. Both Gly and Tau were unaffected by CCK in either dose in both the young and old groups. GABA was not detectable in any of the samples of perfusate throughout the experiments. These results suggest that CCK-8 exerts a selective effect on amino acid neurotransmitter activity in the frontal cortex which is clearly age-dependent. In the older animal, this sensitivity of the cortical cells to CCK may reflect a functional attribute of the peptide in the aging process.

journal_name

Peptides

journal_title

Peptides

authors

Peinado JM,Myers RD

doi

10.1016/0196-9781(88)90175-1

subject

Has Abstract

pub_date

1988-05-01 00:00:00

pages

631-6

issue

3

eissn

0196-9781

issn

1873-5169

pii

0196-9781(88)90175-1

journal_volume

9

pub_type

杂志文章

相关文献

PEPTIDES文献大全
  • Role of neuropeptides in cardiomyopathies.

    abstract：:The role of neuropeptides in cardiomyopathy-associated heart failure has been garnering more attention. Several neuropeptides--Neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), calcitonin gene related peptide (CGRP), substance P (SP) and their receptors have been studied in the various types of cardiomyopathi...

    journal_title：Peptides

    pub_type： 杂志文章,评审

    doi：10.1016/j.peptides.2014.08.004

    authors： Dvorakova MC,Kruzliak P,Rabkin SW

    更新日期：2014-11-01 00:00:00

  • Hepcidin protects against lipopolysaccharide-induced liver injury in a mouse model of obstructive jaundice.

    abstract：:Obstructive jaundice (OJ) increases the risk of liver injury and sepsis, leading to increased mortality. Cholestatic liver injury is associated with a downregulation of hepcidin expression levels. In fact, hepcidin has an important antimicrobial effect, especially against Escherichia coli. It is unknown whether supple...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2012.03.032

    authors： Huang YH,Yang YL,Tiao MM,Kuo HC,Huang LT,Chuang JH

    更新日期：2012-06-01 00:00:00

  • Melanocortin-4 receptors, beta-MSH and leptin: key elements in the satiety pathway.

    abstract：:This paper reviews aspects of our research, focusing on the role of the melanocortin system in the central regulation of feeding and energy balance, which was begun in 1997. It describes data from successive physiological studies, concerning the identity of the appetite-regulating melanocortin receptor, melanocortin-4...

    journal_title：Peptides

    pub_type： 杂志文章,评审

    doi：10.1016/j.peptides.2005.01.030

    authors： Harrold JA,Williams G

    更新日期：2006-02-01 00:00:00

  • Increases in heart rate and blood pressure produced by microinjections of atrial natriuretic factor into the AV3V region of rat brain.

    abstract：:Recent studies have provided evidence for the dense localization of atrial natriuretic factor (ANF) in the anteroventral third ventricle (AV3V) region of the rat brain. This area is currently thought to be involved in the regulation of blood pressure and fluid and electrolyte balance. To investigate whether ANF may pl...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(85)90425-5

    authors： Sills MA,Nguyen KQ,Jacobowitz DM

    更新日期：1985-11-01 00:00:00

  • Beta-endorphin- and GABA-mediated depressor effect of specific electroacupuncture surpasses pressor response of emotional circuit.

    abstract：:It has been proved that input of specific electroacupuncture (EA) can activate beta-endorphin(beta-EP)ergic and noradrenergic neurons projecting to the rostral ventrolateral medulla (RVL), the latter acting upon the RVL-GABAergic interneurons, thereby produce depressor effect. The present study further shows that: (1)...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/s0196-9781(01)00467-3

    authors： Ku YH,Chang YZ

    更新日期：2001-09-01 00:00:00

  • Autoradiographic distribution of 125I calcitonin gene-related peptide binding sites in the rat central nervous system.

    abstract：:Using autoradiographic method and 125I-Tyro rat CGRP as a ligand, receptor binding sites were demonstrated in the rat central nervous system. Saturation studies and Scatchard analysis of CGRP-binding to slide mounted tissue sections containing primarily cerebellum showed a single class of receptors with a dissociation...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(85)90331-6

    authors： Skofitsch G,Jacobowitz DM

    更新日期：1985-09-01 00:00:00

  • Neural mechanism of the antisecretory effect of peptide YY in the rat colon in vivo.

    abstract：:The purpose of this work was to determine the mechanism of the antisecretory effect of peptide YY in the rat colon and whether this effect is physiological. In this prospect, doses of exogenous peptide YY producing physiological and supraphysiological plasma levels were intravenously infused in rats provided with colo...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/s0196-9781(99)00174-6

    authors： Chariot J,Tsocas A,Souli A,Presset O,Rozé C

    更新日期：2000-01-01 00:00:00

  • C-terminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats.

    abstract：:Endomorphin1-ol (Tyr-Pro-Trp-Phe-ol, EM1-ol) and endomorphin2-ol (Tyr-Pro-Phe-Phe-ol, EM2-ol), with C-terminal alcohol (-ol) containing, have been shown to exhibit higher affinity and lower intrinsic efficacy in vitro than endomorphins. In the present study, in order to investigate the alterations of systemic hemodyna...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2005.07.006

    authors： Yu Y,Wang CL,Cui Y,Fan YZ,Liu J,Shao X,Liu HM,Wang R

    更新日期：2006-01-01 00:00:00

  • Functional roles of the NTS2 and NTS3 receptors.

    abstract：:Neurotensin exerts its actions in the central nervous system and the periphery through three identified receptors. Two of them, the NTS2 and NTS3, display unusual properties either because of their complex signal transduction mechanisms (NTS2) or because of their structural composition as a non-G-protein-coupled recep...

    journal_title：Peptides

    pub_type： 杂志文章,评审

    doi：10.1016/j.peptides.2006.04.026

    authors： Mazella J,Vincent JP

    更新日期：2006-10-01 00:00:00

  • Cloning and pharmacological characterization of the neuropeptide Y receptor Y5 in the sea lamprey, Petromyzon marinus.

    abstract：:The neuropeptide Y system is known to have expanded in early vertebrate evolution. Three neuropeptide Y receptors have been proposed to have existed before the two basal vertebrate tetraploidizations, namely a Y1-like, a Y2-like, and a Y5-like receptor, with their genes in the same chromosomal region. Previously we ha...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2012.11.007

    authors： Xu B,Sundström G,Kuraku S,Lundell I,Larhammar D

    更新日期：2013-01-01 00:00:00

  • Central administration of oxytocin reduces hyperalgesia in mice: implication for cannabinoid and opioid systems.

    abstract：:The neuropeptide oxytocin (OXT) contributes to the regulation of diverse cognitive and physiological functions including nociception. Indeed, OXT has been reported to be analgesic when administered directly into the brain, the spinal cord, or systemically. Although many authors have reported the analgesic effects of O...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2012.08.005

    authors： Russo R,D'Agostino G,Mattace Raso G,Avagliano C,Cristiano C,Meli R,Calignano A

    更新日期：2012-11-01 00:00:00

  • Synthesis and biological activity of Boc [Nle28, Nle31]CCK27-33, a highly potent CCK8 analogue.

    abstract：:A new CCK8 related peptide, Boc[Nle28,Nle31]CCK27-33 (Boc[diNle]CCK7) was synthesized and tested for cholecystokinic activity, at both the peripheral and the central level. This analogue, protected against both chemical oxidation and enzymatic degradation by aminopeptidases, was shown to be equipotent to CCK8 in relea...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(85)90106-8

    authors： Ruiz-Gayo M,Daugé V,Menant I,Bégué D,Gacel G,Roques BP

    更新日期：1985-05-01 00:00:00

  • Bombesin increases dopamine function in rat brain areas.

    abstract：:Bombesin is a tetradecapeptide heterogenously distributed in the mammalian brain. Bombesin (45 micrograms) given intracisternally (IC) to unanesthetized rats increased the accumulation of dihydroxyphenylalanine (DOPA) in striatum, olfactory tubercles and hypothalamus after DOPA-decarboxylase inhibition, thus indicatin...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(84)90081-0

    authors： Widerlöv E,Mueller RA,Frye GD,Breese GR

    更新日期：1984-05-01 00:00:00

  • Isolation of Leu-Pro-Pro-Gly-Pro-Leu-Pro-Arg-Pro-NH2 (Antho-RPamide), an N-terminally protected, biologically active neuropeptide from sea anemones.

    abstract：:Using a radioimmunoassay against the C-terminal sequence Arg-Pro-NH2 (RPamide), we have isolated the peptide Leu-Pro-Pro-Gly-Pro-Leu-Pro-Arg-Pro-NH2 (Antho-RPamide) from an extract of the sea anemone Anthopleura elegantissima. Antho-RPamide is located in neurons of sea anemones. Application of low concentrations of An...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(92)90040-a

    authors： Carstensen K,Rinehart KL,McFarlane ID,Grimmelikhuijzen CJ

    更新日期：1992-09-01 00:00:00

  • Sauvagine: effects on gastric acid secretion in rats.

    abstract：:Intracerebroventricular (ICV) and subcutaneous (SC) injections of sauvagine powerfully inhibited gastric acid secretion stimulated by gastric distension and by 2-deoxy-D-glucose, but not by histamine in pylorus-ligated rats. Naloxone failed to antagonize the antisecretory effects of SC and ICV sauvagine. Intravenous i...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(88)90131-3

    authors： Improta G,Broccardo M

    更新日期：1988-07-01 00:00:00

  • Purification and characterization of eight peptides from Galleria mellonella immune hemolymph.

    abstract：:Defense peptides play a crucial role in insect innate immunity against invading pathogens. From the hemolymph of immune-challenged greater wax moth, Galleria mellonella (Gm) larvae, eight peptides were isolated and characterized. Purified Gm peptides differ considerably in amino acid sequences, isoelectric point value...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2006.11.010

    authors： Cytryńska M,Mak P,Zdybicka-Barabas A,Suder P,Jakubowicz T

    更新日期：2007-03-01 00:00:00

  • Urocortin and corticotropin-releasing factor receptor expression in the human colonic mucosa.

    abstract：:Urocortin is a newly identified member of the CRF neuropeptide family. Urocortin has been found to bind with high affinity to CRF receptors. The present study investigated urocortin and CRF receptor expression in human colonic mucosa. Non-pathologic sections of adult colorectal tissues were obtained from patients with...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/s0196-9781(00)00335-1

    authors： Muramatsu Y,Fukushima K,Iino K,Totsune K,Takahashi K,Suzuki T,Hirasawa G,Takeyama J,Ito M,Nose M,Tashiro A,Hongo M,Oki Y,Nagura H,Sasano H

    更新日期：2000-12-01 00:00:00

  • Sub-cellular organization of the melanin-concentrating hormone neurons in the hypothalamus.

    abstract：:Melanin-concentrating hormone (MCH) is a potent orexigenic and sleep-promoting neuropeptide in mammals produced predominately by hypothalamic neurons which project to a wide variety of brain areas. Several MCH producing neurons contain MCH as the only neuropeptide, while others comprise cocaine- and amphetamine regula...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2017.11.002

    authors： Jancsik V,Bene R,Sótonyi P,Zachar G

    更新日期：2018-01-01 00:00:00

  • Protective effect of ghrelin on acetaminophen-induced liver injury in rat.

    abstract：:Ghrelin is a peptide that has protective effects on many tissues of the body. It has anti-inflammatory and anti-oxidant effects. Acetaminophen, a commonly used analgesic-antipyretic drug, has hepatotoxic side effects. The aim of this study was to evaluate the protective role of ghrelin in liver toxicity due to acetami...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2010.08.009

    authors： Golestan Jahromi M,Nabavizadeh F,Vahedian J,Nahrevanian H,Dehpour AR,Zare-Mehrjardi A

    更新日期：2010-11-01 00:00:00

  • In vitro pharmacokinetics of antimicrobial cationic peptides alone and in combination with antibiotics against methicillin resistant Staphylococcus aureus biofilms.

    abstract：:Antibiotic therapy for methicillin-resistant Staphylococcus aureus (MRSA) infections is becoming more difficult in hospitals and communities because of strong biofilm-forming properties and multidrug resistance. Biofilm-associated MRSA is not affected by therapeutically achievable concentrations of antibiotics. Theref...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2013.08.008

    authors： Dosler S,Mataraci E

    更新日期：2013-11-01 00:00:00

  • Circulating neuropeptide Y in plasma from uremic patients consists of multiple peptide fragments.

    abstract：:Increased plasma levels of neuropeptide Y (NPY)-like immunoreactivity (p-NPY-LI) have been described in hemodialysis (HD) patients. In this investigation the effect of a standard HD on p-NPY-LI, analyzed by radioimmunoassay and reverse-phase high performance liquid chromatography (HPLC), was studied. During dialysis p...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(94)00206-l

    authors： Hegbrant J,Thysell H,Ekman R

    更新日期：1995-01-01 00:00:00

  • Dynorphin increases in the dorsal spinal cord in rats with a painful peripheral neuropathy.

    abstract：:It is known that painful tissue injury evokes an increase in dynorphin in spinal neurons. It is not known, however, whether dynorphinergic systems respond similarly to the pain that accompanies peripheral neuropathy. Radioimmunoassays and immunocytochemistry were used to evaluate changes in dynorphin A(1-8) in the spi...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(90)90187-a

    authors： Kajander KC,Sahara Y,Iadarola MJ,Bennett GJ

    更新日期：1990-07-01 00:00:00

  • Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.

    abstract：:Recently we have demonstrated that replacing His(6) by constrained amino acids(2) in the well-known antagonist SHU-9119 resulted in potent and selective antagonist ligands especially at the hMC3R and hMC5 receptors. With the aim to further explore position 6 in the sequence of SHU-9119 and MT-II, we have designed, syn...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2007.02.012

    authors： Grieco P,Cai M,Han G,Trivedi D,Campiglia P,Novellino E,Hruby VJ

    更新日期：2007-06-01 00:00:00

  • Protein phosphorylation in snail cardiocytes stimulated with molluscan peptide SCPb.

    abstract：:Dissociated muscle cells prepared from hearts of the pulmonate snail Helix aspersa were used to study signal transduction induced by molluscan cardioactive peptides. The effects of SCPb on the cAMP levels of whole hearts and the cell preparation were compared. The cells responded to SCPb with a dose-dependent increase...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/s0196-9781(97)00196-4

    authors： Reich G,Doble KE,Greenberg MJ

    更新日期：1997-01-01 00:00:00

  • Biochemical and biophysical combined study of bicarinalin, an ant venom antimicrobial peptide.

    abstract：:We have recently characterized bicarinalin as the most abundant peptide from the venom of the ant Tetramorium bicarinatum. This antimicrobial peptide is active against Staphylococcus and Enterobacteriaceae. To further investigate the antimicrobial properties of this cationic and cysteine-free peptide, we have studied ...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2016.04.001

    authors： Téné N,Bonnafé E,Berger F,Rifflet A,Guilhaudis L,Ségalas-Milazzo I,Pipy B,Coste A,Leprince J,Treilhou M

    更新日期：2016-05-01 00:00:00

  • Central nervous system and peripheral effects of ACTH, MSH, and related neuropeptides.

    abstract：:Adrenocorticotropic Hormone (ACTH), Melanocyte-Stimulating Hormone (MSH), and related peptides have been shown to have several neurogenic effects: alteration of cerebral protein synthesis, RNA synthesis, protein phosphorylation, and neurotransmitter turnover. Furthermore, there appears to be an ACTH containing circuit...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(82)90101-2

    authors： Beckwith BE,Sandman CA

    更新日期：1982-05-01 00:00:00

  • Human RFamide-related peptide-1 diminishes cellular and integrated cardiac contractile performance.

    abstract：:Peptides influence cardiac dysfunction; however, peptidergic modulation of contractile performance remains relatively uncharacterized. We identified a novel human peptide that modulates mammalian contractile performance. Members of the FMRFamide-related peptide (FaRP) family contain a C-terminal RFamide but structural...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2010.07.012

    authors： Nichols R,Demers LA,Larsen BM,Robinson D,Converso K,Russell MW,Westfall MV

    更新日期：2010-11-01 00:00:00

  • Cellular neurophysiological actions of nociceptin/orphanin FQ.

    abstract：:Cellular actions of nociceptin/orphanin FQ (N/OFQ) resemble those of micro-, delta-, and kappa-opioids, i.e. activation of inwardly rectifying K(+) conductance, inhibition of high-voltage-activated Ca(2+) channel currents, and impediment of neurotransmitter release. Differences in ORL(1) and micro-receptor distributio...

    journal_title：Peptides

    pub_type： 杂志文章,评审

    doi：10.1016/s0196-9781(00)00235-7

    authors： Moran TD,Abdulla FA,Smith PA

    更新日期：2000-07-01 00:00:00

  • Quantitative distribution of angiotensin II binding sites in rat brain by autoradiography.

    abstract：:Angiotensin II binding sites were localized and quantified in individual brain nuclei from single rats by incubation of tissue sections with 1 nM 125I-[Sar1]-angiotensin II, [3H]-Ultrofilm autoradiography, computerized microdensitometry and comparison with 125I-standards. High angiotensin II binding was present in the...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(86)90044-6

    authors： Saavedra JM,Israel A,Plunkett LM,Kurihara M,Shigematsu K,Correa FM

    更新日期：1986-07-01 00:00:00

  • Unexpected high density of neuropeptide Y Y1 receptors in the guinea pig spleen.

    abstract：:Receptors for neuropeptide Y (NPY) and peptide YY (PYY) have been extensively characterized in the brain. Less is known about NPY receptor subtypes in the spleen, though it is well established that NPY produces vascular contraction in this tissue. In the present study, we found an unusually high density of Y1 receptor...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/s0196-9781(96)00228-8

    authors： Gehlert DR,Gackenheimer SL

    更新日期：1996-01-01 00:00:00