Abstract:
:Intracerebroventricular (ICV) and subcutaneous (SC) injections of sauvagine powerfully inhibited gastric acid secretion stimulated by gastric distension and by 2-deoxy-D-glucose, but not by histamine in pylorus-ligated rats. Naloxone failed to antagonize the antisecretory effects of SC and ICV sauvagine. Intravenous infusion of sauvagine completely suppressed bethanechol-stimulated gastric secretion, significantly decreased pentagastrin-stimulated gastric secretion and did not modify histamine-stimulated gastric secretion in gastric-perfused rats. The inhibitory effect of sauvagine on gastric secretory response is not mediated through opioid or histamine receptors. It appears to be dependent on a vagal mechanism as well as other mechanisms that await further elucidation.
journal_name
Peptidesjournal_title
Peptidesauthors
Improta G,Broccardo Mdoi
10.1016/0196-9781(88)90131-3subject
Has Abstractpub_date
1988-07-01 00:00:00pages
843-6issue
4eissn
0196-9781issn
1873-5169pii
0196-9781(88)90131-3journal_volume
9pub_type
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