Abstract：
:Angiotensin II (Ang II) uptake and transport across monolayers of bovine brain microvessel endothelial cells (BMECs) was demonstrated. Ang II transport was linear up to 2 h, saturable with a K(m) of 1.7 nM, and tended to be polarized with the apical-to-basolateral transport being greater. [3H]Ang II transport was found to be inhibited by excess unlabeled Ang II, by the Ang II analog sarathrin, and by the endocytic inhibitor phenylarsine oxide. Ang II-(2-8) and-(3-8) were shown to significantly increase the transport of Ang II. These results demonstrate for the first time the receptor-mediated transcytosis of Ang II across brain microvessel endothelium.
journal_name
Peptidesjournal_title
Peptidesauthors
Rose JM,Audus KLdoi
10.1016/s0196-9781(98)00054-0subject
Has Abstractpub_date
1998-01-01 00:00:00pages
1023-30issue
6eissn
0196-9781issn
1873-5169pii
S0196-9781(98)00054-0journal_volume
19pub_type
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