Abstract:
:The effects of atrial natriuretic factor (ANF) on [3H]norepinephrine ([3H]NE) release evoked by a sodium-free medium (SFM) were studied. Experiments were performed in rat adrenal medulla slices incubated in vitro. Results showed that [3H]NE release evoked by the omission of Na+ was decreased by 10 nM ANF. In addition, when the Ca2+ was omitted from the SFM, NE output was partially diminished. Nevertheless, if ANF was added to SFM/Ca(2+)-free medium (CFM), NE secretion showed no modifications compared with SFM/CFM. Present results raise the hypothesis that two mechanisms could be involved in NE output evoked by a SFM in the rat adrenal medulla: one independent of and the other dependent on the extracellular calcium. Moreover, ANF only diminished NE secretion evoked by SFM dependent on extracellular calcium and did not modify calcium-independent NE release.
journal_name
Peptidesjournal_title
Peptidesauthors
Vatta MS,Papouchado ML,Bianciotti LG,Fernandez BEdoi
10.1016/0196-9781(94)90100-7subject
Has Abstractpub_date
1994-01-01 00:00:00pages
709-12issue
4eissn
0196-9781issn
1873-5169pii
0196-9781(94)90100-7journal_volume
15pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::The aim of the present study was to evaluate in hypothalamus and hindbrain of rainbow trout in vitro the effect of leptin treatment on glucosensing capacity and the expression of orexigenic and anorexigenic peptides involved in the control of food intake. In a first experiment, the response of parameters involved in g...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.11.007
更新日期:2011-02-01 00:00:00
abstract::CRF system, structural conservation, has an association with feeding regulation in mammals. However, mammals and fish have different physiological mechanisms, the potential role of CRF system for feeding regulation in teleost fish are most unknown. To better explore possible feeding mechanisms of CRF system in Acipens...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170309
更新日期:2020-06-01 00:00:00
abstract::Natriuretic peptide receptor C (NPR-C) is known to bind all natriuretic peptides with similar affinity. Given their biological role it is interesting that natriuretic peptides and their activated guanylate cyclases (NPR-A and NPR-B) are expressed in retinal amacrine cells. The purpose of this study is to examine the p...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.10.014
更新日期:2010-01-01 00:00:00
abstract::Nesfatin-1 is well established to reduce food intake upon brain injection in rats, while in mice its anorexigenic action and brain expression are largely unexplored. We characterized the influence of intracerebroventricular (icv) and peripheral (intraperitoneal, ip, subcutaneous, sc) injection of nesfatin-1 on dark ph...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.09.027
更新日期:2011-01-01 00:00:00
abstract::In the last 10 years, saliva has been increasingly used as a diagnostic fluid and in predictions of disease progression. Leptin and ghrelin are synthesized in several tissues including the salivary glands. The action of ghrelin is antagonistic to that of leptin. This study was undertaken to measure and compare the sal...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.11.008
更新日期:2005-04-01 00:00:00
abstract::Prolactin releasing peptide (PrRP) was originally reported to act in the anterior lobe of the pituitary gland to stimulate prolactin (PRL) release; however, numerous other pharmacologic actions of PrRP have been described. In the central nervous system PrRP inhibits food intake, stimulates sympathetic tone, and activa...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.01.008
更新日期:2006-05-01 00:00:00
abstract::Motilin-immunopositive cells (Mo cells) are known to be present in the upper small intestine of various species, including man. However, whether Mo cells are present in the rabbit gastrointestinal tract remained to be elucidated. Therefore, this study was designed to investigate the distribution of Mo cells in the rab...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)00046-m
更新日期:1995-01-01 00:00:00
abstract::Growing evidence suggests that the neuropeptide Y (NPY) system plays an important role in the immune system. Yet, little is known about the expression of NPY and receptors in the immune system. Moreover, original contradicting results have confused the picture and hampered a clear understanding of its role in the immu...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2006.09.030
更新日期:2007-02-01 00:00:00
abstract::We studied the ability of NPFF, a FMRFamide-like peptide with certain antiopiate properties, to affect the inhibitory effect of morphine on the electrically induced contraction of guinea pig ileum. Neuropeptide FF had no effect when administered alone but reduced morphine inhibition in a noncompetitive manner. Neurope...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90078-u
更新日期:1993-09-01 00:00:00
abstract::The amino acid sequence of the vasoactive intestinal polypeptide (VIP) is well conserved between species. Thus, all mammalian VIPs isolated so far, except that of the guinea pig, have the same amino acid sequence. This study describes the isolation and primary structure of sheep brain VIP. The purification was followe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90184-7
更新日期:1990-07-01 00:00:00
abstract::The cDNAs encoding the preprohormones of the regulatory peptides cholecystokinin (CCK) and the related gastrin have been identified in a number of vertebrate species. However, from birds only chicken preprogastrin is known. In the present study preproCCK cDNA was identified in two species of birds, ostrich and chicken...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00276-x
更新日期:2000-09-01 00:00:00
abstract::ACTH-(1-24) inhibits the in vitro binding of the muscarinic antagonist [3H]QNB to membranes from rat brain. The magnitude of inhibition is dependent on the concentration of ACTH-(1-24). Kinetic analysis indicates a pure competitive inhibition which is suggestive of a reversible interaction of ACTH with muscarinic rece...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90009-4
更新日期:1986-05-01 00:00:00
abstract::Two peptides, with a molecular mass of about 11 kDa and an N-terminal sequence abundant in arginine and glutamine residues, were isolated from wax gourd seeds. The isolation protocol included affinity chromatography on Affi-gel blue gel, ion-exchange chromatography on Mono-S and gel filtration on Superdex 75. The pept...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00271-1
更新日期:2003-01-01 00:00:00
abstract::Trefoil factors family 2 (TFF2), also known as spasmolytic polypeptide, is primarily expressed in the mucus neck cells of gastrointestinal tracts. It has been proposed that TFF2 plays an important physiological role in protection, repair, and healing of gastrointestinal mucosa. To investigate the cis-acting regulatory...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.11.022
更新日期:2004-05-01 00:00:00
abstract::Effects of spantide ([D-Arg1,D-Trp7,9,Leu11]substance P) on coronary resistance vessels were studied in isolated guinea pig hearts perfused at constant rate with isotonic buffer containing 20 or 40 mM KCl. Spantide (1 microM) caused a 20-fold rightward shift of the substance P (SP) dose-response curve for vasodilation...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90047-s
更新日期:1991-09-01 00:00:00
abstract::The heptadecapeptide, orphanin FQ or nociceptin (Phe-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln), originally isolated from rat brain has been identified as an endogenous ligand for the orphan opioid-like receptor. Although orphanin FQ shares some sequence and structural homology with kappa-opioid pept...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00037-5
更新日期:1997-01-01 00:00:00
abstract::Studies involving altered energy balance states in rodents have demonstrated that hypothalamic neuropeptide Y (NPY) activity is strongly activated in states of negative energy balance, such as periods of dietary restriction or starvation. However, in cancer cachexia, when there is a significant reduction in body weigh...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00183-7
更新日期:2000-01-01 00:00:00
abstract::Androgenic gland hormone (AGH) is known to be responsible for sex differentiation in crustaceans. The amino acid sequence of AGH-active fraction purified from androgenic glands of the terrestrial isopod Armadillidium vulgare was determined by immunoprecipitation employing three types of antibodies raised against diffe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00374-0
更新日期:2001-02-01 00:00:00
abstract::This paper reviews aspects of our research, focusing on the role of the melanocortin system in the central regulation of feeding and energy balance, which was begun in 1997. It describes data from successive physiological studies, concerning the identity of the appetite-regulating melanocortin receptor, melanocortin-4...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2005.01.030
更新日期:2006-02-01 00:00:00
abstract::The functions of leptin receptors (LRs) are cell-type specific. At the blood-brain barrier, LRs mediate leptin transport that is essential for its CNS actions, and both endothelial and astrocytic LRs may be involved. To test this, we generated endothelia specific LR knockout (ELKO) and astrocyte specific LR knockout (...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.05.011
更新日期:2011-07-01 00:00:00
abstract::Recent pharmacological data strongly support the hypothesis of delta receptor subtypes as mediators of both supraspinal and spinal antinociception (delta 1 and delta 2 receptors). In vitro ligand binding data, which are fully supportive of the in vivo data, are still lacking. A previous study indicated that [3H][D-Ala...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90030-7
更新日期:1992-11-01 00:00:00
abstract::Human bombesin receptors, GRPR and NMBR, are two of the most frequently overexpressed G-protein-coupled-receptors by lung-cancers. Recently, GRPR/NMBR are receiving considerable attention because they act as growth factor receptors often in an autocrine manner in different lung-cancers, affect tumor angiogenesis, thei...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.01.016
更新日期:2018-03-01 00:00:00
abstract::A novel 6.6 kDa antifungal peptide (NFAP) from the culture supernatant of the mold, Neosartorya fischeri (anamorf: Aspergillus fischerianus), and its encoding gene were isolated in this study. NFAP is a small, basic and cysteine-rich protein consisting of 57 amino acid residues. It shows 37.9-50% homology to similar p...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.06.022
更新日期:2011-08-01 00:00:00
abstract::In the present study, the newly synthesized TRH analog (L-pGlu-(2-propyl)-L-His-l-ProNH(2); NP-647) was evaluated for its effects in in vitro (oxygen glucose deprivation (OGD)-, glutamate- and H(2)O(2)-induced injury in PC-12 cells) and in vivo (transient global ischemia) models of cerebral ischemic injury. PC-12 cell...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.04.006
更新日期:2011-06-01 00:00:00
abstract::We investigated the ability of sulfated cholecystokinin (26-33) (CCK-8) and cholecystokinin (30-33) (CCK-4) to induce taste aversion or avoidance conditioning (TAC) in a one-bottle testing paradigm after either intravenous (i.v.), intracerebroventricular (i.c.v.), or intraperitoneal (i.p.) administration. Significant ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00025-4
更新日期:1998-01-01 00:00:00
abstract::We have studied the in vitro effect of VIP and histamine on ultrastructure of the parietal cells in isolated guinea pig fundic glands. The morphological changes induced by histamine in the parietal cells can be compared to those observed after histamine stimulation in vivo or in vitro on gastric mucosa preparations. I...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90219-5
更新日期:1984-03-01 00:00:00
abstract::Despite the high impact of the antimicrobial peptide hepcidin in iron homeostasis, the regulation of this hormone is still not completely understood. Studies concerning hepcidin regulation are performed at the mRNA level. For the first time we analyzed the regulation of hepcidin not only at mRNA, but also at protein l...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.01.016
更新日期:2007-05-01 00:00:00
abstract::HP-1 is the most abundant human representative of a recently discovered class of neutrophil cystine- and arginine-rich peptides. These peptides have many potentially regulatory activities expressed at nanomolar concentrations. To establish the levels of HP-1 that can accumulate in human lung tumors and nondiseased lun...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90152-s
更新日期:1992-01-01 00:00:00
abstract::Angiotensin-(1-7) [Ang-(1-7)] develops its functions interacting with Mas receptor. Mas receptor was recently identified in the DRG and its activation by Ang-(1-7) resulted in peripheral antinociception against PGE2 hyperalgesia in an opioid-independent pathway. Nevertheless, the mechanism by which Ang-(1-7) induce pe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2015.04.011
更新日期:2015-07-01 00:00:00
abstract::This paper reports the purification and biochemical/pharmacological characterization of two myotoxic phospholipases A(2) (PLA(2)s) from Bothrops brazili venom, a native snake from Brazil. Both myotoxins (MTX-I and II) were purified by a single chromatographic step on a CM-Sepharose ion-exchange column up to a high pur...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.05.021
更新日期:2008-10-01 00:00:00