Abstract:
:The amino acid sequence of the vasoactive intestinal polypeptide (VIP) is well conserved between species. Thus, all mammalian VIPs isolated so far, except that of the guinea pig, have the same amino acid sequence. This study describes the isolation and primary structure of sheep brain VIP. The purification was followed with a bioassay and a VIP receptor assay. The amino acid sequence of the isolated sheep VIP is identical to that of the pig, human, ox, rat, rabbit, goat and dog VIP.
journal_name
Peptidesjournal_title
Peptidesauthors
Gafvelin Gdoi
10.1016/0196-9781(90)90184-7subject
Has Abstractpub_date
1990-07-01 00:00:00pages
703-6issue
4eissn
0196-9781issn
1873-5169pii
0196-9781(90)90184-7journal_volume
11pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Rhesus monkey MCH-R1 and MCH-R2 receptors were cloned. Amino acid homology is 98.8% between monkey and human MCH-R1, while monkey and human MCH-R2 are 98% homologous. Binding and intracellular signaling characteristics of the monkey receptors were compared with the human homologues. The results demonstrate that MCH bi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00077-3
更新日期:2002-08-01 00:00:00
abstract::Catestatin (CST) is an endogenous neuropeptide with multiple cardiovascular activities. The study is to investigate circulating CST levels in heart failure (HF) patients and to evaluate the role of CST as a biomarker for HF. Plasma CST concentrations were measured by enzyme-linked immunosorbent assay in 228 HF patient...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.05.003
更新日期:2013-08-01 00:00:00
abstract::Immunohistochemical localization of Met-enkephalin, Met-enkephalin-Arg6-Gly7-Leu8, Met-enkephalin-Arg6-Phe7 and Leu-enkephalin was studied in human adrenal medulla and pheochromocytomas at the light and electron microscopic levels. Both adrenal medulla and pheochromocytomas (4 adrenal, 1 extra-adrenal) showed scattere...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90126-8
更新日期:1984-09-01 00:00:00
abstract::Neuropeptide Y (NPY) induces feeding in previously satiated animals after injection into the hypothalamus, especially the perifornical region (PFH). NPY also appears to have rewarding properties as evidenced by its ability to produce a conditioned place preference following injection into the nucleus accumbens (N.Acc)...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00117-x
更新日期:1998-01-01 00:00:00
abstract::Endocrine regulation in vertebrates is critical for the adaptation and regulation of homeostasis. The G protein-coupled receptor (GPCR) signaling transduction system represents one of the most ancient forms of cell surface signaling. Recently, comparative sequence analysis has aided in the identification and pairing o...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2004.05.021
更新日期:2004-10-01 00:00:00
abstract::Calcification-associated peptide (CAP)-1 is considered to play an important role in calcification of the exoskeleton of the crayfish, Procambarus clarkii. In this study, in order to clarify the molecular mechanism of calcification, we constructed expression systems of recombinant molecules of CAP-1 and its related pep...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.12.005
更新日期:2007-03-01 00:00:00
abstract::We investigated basal motility and the motor effects of motilin, erythromycin, and prostigmine on segments of rabbit gastrointestinal tract removed from extrinsic neural and vascular pathway and immersed in an oxygenated organ bath. Motility was recorded by means of four strain gauges sutured on the serosal surface of...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90072-8
更新日期:1994-01-01 00:00:00
abstract::The actions of a behaviorally active luteinizing hormone-releasing hormone fragment, Ac-LHRH(5-10), on CA1 pyramidal cells were studied utilizing conventional intracellular recordings from the in vitro rat hippocampal slice preparation. The behaviorally active fragment (10(-7) M) and the natural decapeptide [LHRH(1-10...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90090-4
更新日期:1993-09-01 00:00:00
abstract::Peptides influence cardiac dysfunction; however, peptidergic modulation of contractile performance remains relatively uncharacterized. We identified a novel human peptide that modulates mammalian contractile performance. Members of the FMRFamide-related peptide (FaRP) family contain a C-terminal RFamide but structural...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.07.012
更新日期:2010-11-01 00:00:00
abstract::Our previous findings that the degree of endotoxin-induced hypotension in the dog is inversely related to ambient temperature (19 degrees through 30 degrees C) and that only increased doses of naloxone are effective at 19 degrees C suggested that opioid activity is also influenced by ambient temperature, increasing in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90007-5
更新日期:1985-01-01 00:00:00
abstract::Apamin is a neurotoxic octadecapeptide from bee venom, which has been shown to inhibit the non-adrenergic, non-cholinergic inhibitory innervation of the smooth muscle of the gut. Since vasoactive intestinal polypeptide (VIP) has been proposed as a possible inhibitory neurotransmitter, the effect of apamin on the recep...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90102-x
更新日期:1983-03-01 00:00:00
abstract::Binding sites in the rat forebrain were characterized using (125I-Tyr4)bombesin as a receptor probe. Pharmacology experiments indicate that gastrin releasing peptide (GRP) and the GRP fragments GRP as well as Ac-GRP inhibited radiolabeled (Tyr4)bombesin binding with high affinity. Biochemistry experiments indicated th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90018-x
更新日期:1985-01-01 00:00:00
abstract::Cocaine- and amphetamine-regulated transcript (CART) is a neurotransmitter and hormone, involved in the regulation of e.g. food intake, body weight, reward and addiction, and stress response. CART has also been found to affect insulin secretion and beta cell morphology, both in vivo and in vitro. Furthermore, CART aff...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170431
更新日期:2021-01-01 00:00:00
abstract::Jingzhaotoxin-II (JZTX-II) is a 32-residue peptide from the Chinese tarantula Chilobrachys jingzhao venom, and preferentially inhibits the fast inactivation of the voltage-gated sodium channels (VGSCs) in rat cardiac myocytes. In the present study, we elucidated the action mechanism of JZTX-II inhibiting hNav1.5, a VG...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2015.03.012
更新日期:2015-06-01 00:00:00
abstract::Arginine-vasopressin (AVP) is a hypothalamic hormone that, like CRH, stimulates the pituitary release of ACTH, thereby activating adrenal glucocorticoid secretion. Evidence indicates that rat adrenal medulla contains a CRH-ACTH system duplicating that existing at the hypothalamo-pituitary level and involved in the par...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(96)00294-x
更新日期:1997-01-01 00:00:00
abstract::The effects of iontophoretically applied human pancreatic growth hormone-releasing factor (hpGRF), peptide histidine isoleucine (PHI-27), and somatostatin (SS) on the extracellular activity of single cells in the hypothalamus, thalamus, and cortex of the rat brain were studied in urethane-anesthetized, male rats. Neur...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90161-5
更新日期:1985-07-01 00:00:00
abstract::Ghrelin, a novel gut hormone, has been shown to exert protective effects on cardiac dysfunction and remodeling. However, the underlying mechanisms of its protective effects remain unclear. Here, we investigated the effects of ghrelin on cardiac hypertrophy and explored the mechanisms involved. Ghrelin (30 μg.kg-1. day...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170446
更新日期:2020-11-13 00:00:00
abstract::Parathyroid hormone (PTH) has been shown to have actions within the brain, suggesting the presence of central PTH receptors. This possibility was examined by determining the binding of 125I-labeled [Nle8,18,Tyr34]bovine PTH to the plasma membranes of rat and rabbit brains. Specific binding of the tracer to membranes o...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90174-f
更新日期:1993-11-01 00:00:00
abstract::The peptidome of the central nervous system of adult cabbage root fly, Delia radicum (L) was investigated using matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS). Over twenty neuropeptides were identified from three different tissue sources, the combined brain/suboesophageal g...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.08.028
更新日期:2011-03-01 00:00:00
abstract::Neuropeptide Y (NPY) receptor binding sites have been characterized in rat brain using both membrane preparations and receptor autoradiography. Radiolabelled NPY binds with high affinity and specificity to an apparent single class of sites in rat brain membrane preparations. The ligand selectivity pattern reveals stro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90061-6
更新日期:1986-01-01 00:00:00
abstract::By using specific antibodies and radioimmunological and immunohistochemical methods, we here show that neuropeptide FF (NPFF) occurs in cervical and lumbar dorsal root ganglia cells. Levels in the ganglia were low because they were detectable only after colchicine treatment or after unilateral dorsal rhizotomy. Simila...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00039-x
更新日期:1999-01-01 00:00:00
abstract::The aim of the present study was to correlate the development of the renin angiotensin system (RAS) in the kidney of the rat with the development of genetic hypertension. Immature (1-week-old) and adult (12-week-old) normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive kidney rats (SHR) were used for quantif...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)00150-5
更新日期:1995-01-01 00:00:00
abstract::The oligopeptide transporter (PepT1) is located on the brush-border membrane of the intestinal epithelium which has been regarded as a mediator of protein absorption. Here, we cloned and characterized PepT1 genes from diploid (red crucian carp), triploid and tetraploid fish. Then, the PepT1 expression pattern in diffe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.12.017
更新日期:2014-02-01 00:00:00
abstract::The hypocretins (1 and 2) have emerged as key regulators of sleep and wakefulness. We developed a high-throughput enzyme immunoassay (EIA) to measure total brain hypocretin levels from large numbers of mice. Hypocretin levels were not altered by circadian time or age. However, significant differences in one or both hy...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00251-6
更新日期:2002-12-01 00:00:00
abstract::We have used high performance liquid chromatography and radioimmunoassay to characterize the CCK-like molecules in the central nervous system. The major form of CCK is the sulfated octapeptide. This molecule is distributed unevenly among various brain regions; the highest levels are found in the cortex and striatum. W...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(81)90015-2
更新日期:1981-01-01 00:00:00
abstract::HPLC characterization of tilapia pituitary endorphins using an antibody specific for N-terminally acetylated endorphins yielded three major peaks in the neurointermediate lobe, but none in the pars distalis. The melanotropes secreted two of the immunoreactive products in vitro, one of which coeluted with Xenopus laevi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)00204-j
更新日期:1995-01-01 00:00:00
abstract::So far numerous antimicrobial peptides have been characterized from amphibians. In this work, a new family of antimicrobial peptides, named shuchin, was purified and characterized from skin secretions of the frog, Rana shuchinae that lives in freezing mountains. Totally two members of shuchin (shuchin 1 and 2) were id...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.05.014
更新日期:2010-09-01 00:00:00
abstract::[125I]beta-endorphin bound to high affinity (Kd = 0.25 nM) receptors in the caudal dorsomedial medulla of rats with a Bmax of 97 fmol/mg protein. The relative potency for displacement of [125I]beta-endorphin binding was: beta-endorphin(1-31) > beta-endorphin(1-27) > DAMGO > naloxone > N-acetyl-beta-endorphin(1-31) > U...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00024-2
更新日期:1998-01-01 00:00:00
abstract::There have been few reports on the effects of the brain-gut peptide motilin on the central nervous system (CNS). We administered motilin intracerebroventricularly to mice and investigated the effect of motilin on anxiety using an elevated plus-maze. Motilin produced a significant decrease in anxiety with an inverted U...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00131-4
更新日期:1998-01-01 00:00:00
abstract::Higher plasma copeptin level has been associated with poor outcomes of critical illness. The present study was undertaken to investigate the plasma copeptin concentrations in children with traumatic brain injury (TBI) and to analyze the correlation of copeptin with disease outcome. Plasma copeptin concentrations of 12...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.01.015
更新日期:2013-04-01 00:00:00