Abstract:
:We studied the ability of NPFF, a FMRFamide-like peptide with certain antiopiate properties, to affect the inhibitory effect of morphine on the electrically induced contraction of guinea pig ileum. Neuropeptide FF had no effect when administered alone but reduced morphine inhibition in a noncompetitive manner. Neuropeptide FF also altered the inhibitory effect of opioid peptides as released by an intense electrical stimulation at 10 Hz. These results suggest that NPFF receptors exist in guinea pig ileum in association with opiate receptors, and that endogenous NPFF may play a role in the diarrhea observed in the morphine withdrawal syndrome.
journal_name
Peptidesjournal_title
Peptidesauthors
Demichel P,Rodriguez JC,Roquebert J,Simonnet Gdoi
10.1016/0196-9781(93)90078-usubject
Has Abstractpub_date
1993-09-01 00:00:00pages
1005-9issue
5eissn
0196-9781issn
1873-5169pii
0196-9781(93)90078-Ujournal_volume
14pub_type
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