Abstract:
:Herein the effect of orexin receptor type-1 antagonist SB-334867 on the development of tolerance to analgesic effects of morphine was studied in rats. To incite tolerance, morphine sulfate was injected intraperitoneally (i.p., 10mg/kg) once a day for 7 days. The tail flick test was used to evaluate antinociceptive effects of the morphine. A selective OxR1 receptor antagonist, SB-334867, was microinjected (i.c.v.) into the right cerebral ventricle (10 μg/10 μl) immediately before each morphine injection. Repeated morphine application resulted in tolerance to morphine analgesic effects as a decreasing trend during 7 days. Also, repeated administration of SB-334867 (i.c.v.) alone was without significant effect on the nociception as compared to control. Microinjection of SB-334867 prior to each morphine injection inhibited the development of tolerance, so that the analgesic effects of morphine were significantly higher in SB-334867 plus morphine treated rats than that of vehicle plus morphine treated ones on days 4-7. It is concluded that orexin receptor type-1 might be involved in the development of tolerance to morphine analgesic effects.
journal_name
Peptidesjournal_title
Peptidesauthors
Ranjbar-Slamloo Y,Azizi H,Fathollahi Y,Semnanian Sdoi
10.1016/j.peptides.2012.02.023subject
Has Abstractpub_date
2012-05-01 00:00:00pages
56-9issue
1eissn
0196-9781issn
1873-5169pii
S0196-9781(12)00114-3journal_volume
35pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::The UII and urotensin II-related peptide (URP) genes belong to the same superfamily as the somatostatin gene. It has been previously shown that somatostatin activates the UII-receptor (UTR). In contrast, the possible interaction between UII and URP and somatostatin receptors has remained scarcely analyzed. Herein, we ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.12.015
更新日期:2008-05-01 00:00:00
abstract::Immunocytochemistry using an antiserum to the C-terminal octapeptide of synenkephalin, proenkephalin(63-70), was performed throughout the rat brain and revealed numerous immunopositive fibers and some cell bodies. The morphology and distribution of synenkephalin immunoreactivity was extremely similar to that of a comm...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90018-1
更新日期:1989-11-01 00:00:00
abstract::Calcification-associated peptide (CAP)-1 is considered to play an important role in calcification of the exoskeleton of the crayfish, Procambarus clarkii. In this study, in order to clarify the molecular mechanism of calcification, we constructed expression systems of recombinant molecules of CAP-1 and its related pep...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.12.005
更新日期:2007-03-01 00:00:00
abstract::Angiotensin II (Ang II) uptake and transport across monolayers of bovine brain microvessel endothelial cells (BMECs) was demonstrated. Ang II transport was linear up to 2 h, saturable with a K(m) of 1.7 nM, and tended to be polarized with the apical-to-basolateral transport being greater. [3H]Ang II transport was foun...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00054-0
更新日期:1998-01-01 00:00:00
abstract::The reperfusion injury salvage kinase (RISK) pathway is a fundamental signal transduction cascade in the cardioprotective mechanism of ischemic postconditioning. In the present study, we examined the cardioprotective role of oxytocin as a postconditioning agent via activation of the RISK pathway (PI3K/Akt and ERK1/2)....
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2016.10.001
更新日期:2016-12-01 00:00:00
abstract::The distribution of urotensin I (UI) and corticotropin-releasing factor (CRF) immunoreactive (IR) structures was studied in the central nervous system (CNS) of the white sucker using the peroxidase-antiperoxidase immunocytochemical procedure. The close sequence homology between both peptides resulted in a high degree ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90065-3
更新日期:1986-01-01 00:00:00
abstract::We measured the concentration of beta-endorphin (beta-End) in plasma, as well as in aqueous humor and crystalline lens removed during cataract surgery. beta-End was detected both in the aqueous humor and in the crystalline lens. The concentration of beta-End in the aqueous humor corresponded to almost the half of the ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00379-5
更新日期:2001-04-01 00:00:00
abstract::Neuropeptide S (NPS), the endogenous ligand of NPS receptor (NPSR), regulates many biological functions, including arousal, anxiety, locomotion and food intake. NPSR mRNA is expressed in several regions of central autonomic network through which the brain controls visceromotor and other responses essential for surviva...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.03.012
更新日期:2009-07-01 00:00:00
abstract::The family of natriuretic peptides (NPs) discovered in mammalian tissues including cardiac atrium and brain consists of three members, namely, atrial, B- and C-type natriuretic peptides (ANP, BNP, CNP). Since the discovery, basic and clinical studies have been vigorously performed to explore the biological functions a...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2020.170352
更新日期:2020-10-01 00:00:00
abstract::Atrial dipeptidyl carboxyhydrolase readily converts one atrial natriuretic peptide, atriopeptin II (Ser103-Arg125 peptide), to another, atriopeptin I (Ser103-Ser123 peptide), by selective removal of the C-terminal dipeptide, Phe-Arg. The atrial peptides possess natriuretic, diuretic, smooth muscle relaxant, and cardio...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90077-6
更新日期:1989-01-01 00:00:00
abstract::Guinea pig VIP differs from VIP of several mammals by its amino acids in positions 5, 9, 19 and 26. We tested a) its ability to occupy VIP receptors in liver and lung membranes of rat and guinea pig and in the human lymphoblastic SUP-T1 cell line and b) the ensuing adenylate cyclase stimulation. In liver and lung memb...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90180-w
更新日期:1991-01-01 00:00:00
abstract::Endomorphin 1 (EM-1) and EM-2 have been widely reported in the cells of the central nervous system (CNS) but limited research has been done regarding their distribution in the peripheral system. The occurrence of EM-1 and -2 in the spleen as measured by RIA and their ability to mediate immune function imply a role for...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.11.016
更新日期:2004-01-01 00:00:00
abstract::Prader-Willi syndrome is characterized by dramatic hyperphagia and morbid obesity, and is associated with a deficiency in basal and meal-stimulated serum pancreatic polypeptide (PP) levels. Intravenous infusions of pancreatic polypeptide (90 min, 50 pmol/kg/h) restored normal serum PP levels, and a regimen of morning ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90138-7
更新日期:1993-05-01 00:00:00
abstract::In the present review we reevaluated the experimental and clinical evidence that there is a local renin angiotensin system in the heart as well as the presence of a functional intracrine component which is activated during pathological conditions like heart failure and hypertension. The implications of these findings ...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2011.06.018
更新日期:2011-08-01 00:00:00
abstract::The effect of EGF on the incorporation of [3H]TdR into DNA (DNA synthesis) was determined in the esophagus, liver, pancreas, and kidney in mice standardized to 12 hours (hr) of light alternating with 12 hr of darkness. A question asked was whether intraperitoneally administered EGF could alter the circadian patterns o...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90110-0
更新日期:1987-03-01 00:00:00
abstract::The acute behavioral effects of some neurohypophyseal hormones after intracerebroventricular injection in mice were examined. The effects, consisting mainly of a dose-dependent stimulation of certain behaviors, were demonstrated in three different behavioral tests. The type of the induced behaviors was dependent on th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(81)80003-4
更新日期:1981-04-01 00:00:00
abstract::We demonstrated previously that hippocampal dentate gyrus neurons were sensitive to angiotensin II (AII) and recently discovered that AII applied directly to the dentate gyrus inhibited granule cell long-term potentiation induction and that the inhibition is mediated by the AT1 receptor and can be blocked by losartan,...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)00073-s
更新日期:1995-01-01 00:00:00
abstract::Opioid-like immunoreactive material was extracted from the pituitary and brain of the Spiny Dogfish Shark Squalus acanthias. The immunoreactive material in the pituitary extracts was purified to apparent homogeneity by reverse phase high performance liquid chromatography and subsequently characterized by amino acid an...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90071-9
更新日期:1986-01-01 00:00:00
abstract::This report summarizes recent work on the chemistry and structure-activity relationships of crustacean chromatophorotropic pigment-dispersing hormones (PDHs) and the identification of structurally related peptides from insects. So far, the primary structures of crustacean alpha-PDH and beta-PDH and of a pigment-disper...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/0196-9781(88)90239-2
更新日期:1988-01-01 00:00:00
abstract::CART (cocaine- and amphetamine-regulated transcript) peptides are neuropeptides abundant in the central nervous system and periphery found to be involved in the regulation of food intake behavior and other physiological processes. Recently, we reported specific binding of (125)I-CART(61-102) to the rat adrenal pheochr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.07.022
更新日期:2007-10-01 00:00:00
abstract::In experimental models and in humans, somatostatin (SRIF) is able to contract certain vascular structures. The present experiments were designed to assess the capacity of SRIF to contract cultured rat aortic vascular smooth muscle cells (VSMC), and to analyze the possible mechanisms involved. Cells incubated with SRIF...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00083-2
更新日期:1999-01-01 00:00:00
abstract::Investigators studying the primary culprit responsible for Alzheimer disease have, for the past two decades, primarily focused on amyloid-beta (Abeta). Here, we put Abeta on trial and review evidence amassed by the prosecution that implicate Abeta and also consider arguments and evidence gathered by the defense team w...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(02)00069-4
更新日期:2002-07-01 00:00:00
abstract::We demonstrated the production and release of a peptide structurally identical with porcine and bovine VIP-28 in human neuroblastoma NB-OK-1 cell line. In the cells, VIP-like immunoreactive (IR-VIP) components of 8 K dalton (Kd), 11 Kd, 18 Kd and 30 Kd were also detected and the 8 Kd and 18 Kd components were apparent...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90199-2
更新日期:1984-03-01 00:00:00
abstract::The detection of the prodynorphin gene in anuran amphibians and lungfishes may indicate that this gene arose as a result of the duplication of the proenkephalin gene early during the divergence of the Sarcopterygii, or that this gene may predate the divergence of the ray-finned fish and the lobe-finned fish. The cloni...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.09.007
更新日期:2006-04-01 00:00:00
abstract::We have developed a radioimmunoassay for synthetic dynorphin B, a novel opioid tridecapeptide, which shares a common precursor molecule with dynorphin1-17 (= dynorphin A) and the neo-endorphins. The levels of immunoreactivity towards this peptide in rat brain and pituitary show a pattern quantitatively and qualitative...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90083-9
更新日期:1983-11-01 00:00:00
abstract::Arginine vasopressin (AVP), which is synthesized and secreted in the hypothalamic paraventricular nucleus (PVN), is the most important bioactive substance in the pain modulation. Our pervious study had shown that AVP plays an important role in pain modulation in caudate nucleus (CdN). The experiment was designed to in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.10.014
更新日期:2011-01-01 00:00:00
abstract::Pituitary cells from 14-day-old rats were separated by unit gravity velocity sedimentation, and a highly enriched population of gonadotrophs was established in reaggregate cell culture in serum-free and serum albumin-free defined culture media. The medium conditioned by these aggregates was concentrated, ultrafiltrate...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90217-8
更新日期:1994-01-01 00:00:00
abstract::Tachykinins are multifunctional neuropeptides that have been identified in vertebrates as well as invertebrates. The C-terminal FXGXRa-motif constitutes the consensus active core region of invertebrate tachykinins. In Drosophila, two putative G protein-coupled tachykinin receptors have been cloned: DTKR and NKD. This ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.06.014
更新日期:2007-01-01 00:00:00
abstract::The effect of synthetic human calcitonin gene-related peptide (hCGRP) on the isolated and electrically driven left atria of rats were investigated. The peptide at concentrations of 3 X 10(-9)-3 X 10(-7) M produced positive inotropic effects on the left atria in a dose-dependent manner. Verapamil (10(-5) M) and adenosi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90038-0
更新日期:1986-07-01 00:00:00
abstract::The distribution of somatostatin (SRIF) was examined in normal human forebrain, using thick vibratome cut sections. The unlabeled antibody enzyme method of immunocytochemistry revealed a widespread distribution of SRIF immunoreactive neurons and fibers throughout the septum, diencephalon and corpus striatum. Within th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90109-9
更新日期:1986-09-01 00:00:00