Abstract:
:The distribution of somatostatin (SRIF) was examined in normal human forebrain, using thick vibratome cut sections. The unlabeled antibody enzyme method of immunocytochemistry revealed a widespread distribution of SRIF immunoreactive neurons and fibers throughout the septum, diencephalon and corpus striatum. Within the septum SRIF neurons and fibers were observed in the medial and lateral septal nuclei, the nucleus of the diagonal band, the nucleus accumbens and the bed nucleus of the stria terminalis. SRIF neurons and fibers were found in several hypothalamic and anterior thalamic nuclei as well as all regions of the corpus striatum. An interesting collection of SRIF immunoreactive neurons and processes were observed forming a wide band extending anteriorly from the lateral preoptic area through the lateral hypothalamus and substantia innominata posteriorly. This report on the localization of immunoreactive SRIF in the human forebrain extends previous anatomical findings and lends morphological support to recent biochemical studies.
journal_name
Peptidesjournal_title
Peptidesauthors
Bennett-Clarke CA,Joseph SAdoi
10.1016/0196-9781(86)90109-9subject
Has Abstractpub_date
1986-09-01 00:00:00pages
877-84issue
5eissn
0196-9781issn
1873-5169pii
0196-9781(86)90109-9journal_volume
7pub_type
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