Abstract:
:The acute behavioral effects of some neurohypophyseal hormones after intracerebroventricular injection in mice were examined. The effects, consisting mainly of a dose-dependent stimulation of certain behaviors, were demonstrated in three different behavioral tests. The type of the induced behaviors was dependent on the experimental conditions: If the mice were placed into a cage after the injection of the peptides, excessive scratching and grooming behaviors were induced. If they were exposed to stressful environmental influences, however, escape-directed activity was markedly stimulated with only minimal elevation of scratching and grooming behaviors. Very low doses down to less than 1 nanogram per mouse were effective. The effects can be observed after central, but not after peripheral application of the peptides and are mediated by a mechanism that displays some degree of specificity. An activity unit for the behavior-altering potency of the peptides was defined. A role of neurohypophyseal hormones or related peptides in the regulation of motivation and behavioral arousal is suggested.
journal_name
Peptidesjournal_title
Peptidesauthors
Meisenberg Gdoi
10.1016/s0196-9781(81)80003-4subject
Has Abstractpub_date
1981-04-01 00:00:00pages
1-8issue
1eissn
0196-9781issn
1873-5169pii
S0196-9781(81)80003-4journal_volume
2pub_type
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