On the local cardiac renin angiotensin system. Basic and clinical implications.

abstract：:Energy homeostasis is controlled by a complex neuroendocrine system consisting of peripheral signals like leptin and central signals, in particular, neuropeptides. Several neuropeptides with anorexigenic (POMC, CART, and CRH) as well as orexigenic (NPY, AgRP, and MCH) actions are involved in this complex (partly redun...

journal_title：Peptides

authors： Hillebrand JJ,de Wied D,Adan RA

更新日期：2002-12-01 00:00:00

abstract：:Human Zonulin, related to the Zonula occludens toxin of Vibrio cholerae, regulates intestinal permeability and is induced in inflammatory disorders of the lower GI tract. Gastroesophageal reflux disease (GERD) is associated with an impairment of epithelial barrier function. Here, we studied expression of zonulin in th...

journal_title：Peptides

authors： Wex T,Mönkemüller K,Kuester D,Fry L,Kandulski A,Malfertheiner P

更新日期：2009-06-01 00:00:00

abstract：:We have developed a semi-intact preparation-consisting of an isolated oviduct with abdominal ganglia VII and VIII intact and attached-with which to characterize the effects on oviduct contraction, of peptides that are bath applied to CNS tissues. The work presented here offers a qualitative analysis of the central eff...

journal_title：Peptides

authors： Kwok R,Orchard I

更新日期：2002-11-01 00:00:00

abstract：:The effects of iontophoretically applied human pancreatic growth hormone-releasing factor (hpGRF), peptide histidine isoleucine (PHI-27), and somatostatin (SS) on the extracellular activity of single cells in the hypothalamus, thalamus, and cortex of the rat brain were studied in urethane-anesthetized, male rats. Neur...

journal_title：Peptides

authors： Twery MJ,Moss RL

更新日期：1985-07-01 00:00:00

abstract：:Metabolism of orphanin FQ/nociceptin (OFQ/N) was studied in the spinal cord of rats. The heptadecapeptide was efficiently cleaved by a neutral serine endopeptidase, thus releasing the major metabolite, OFQ/N(1-11), further truncated to the final product, OFQ/N(1-6). Biologic activity of this latter fragment was tested...

journal_title：Peptides

authors： Suder P,Kotlinska J,Smoluch MT,Sällberg M,Silberring J

更新日期：1999-01-01 00:00:00

abstract：:Pea albumin 1F (PA1F), a plant peptide isolated from pea seeds, can dramatically increase blood glucose concentration by subcutaneous injection with a dosage of 5 or 10 microg/g (body weight) in normal and type II diabetic mice (KK/upj-Ay). The voltage-dependent anion channel 1 (VDAC-1) has been identified as the PA1F...

journal_title：Peptides

authors： Dun XP,Li FF,Wang JH,Chen ZW

更新日期：2008-06-01 00:00:00

abstract：:High levels of neuropeptide Y (NPY) are found in the hypothalamus, median eminence, pituitary portal blood, and the pituitary in a number of species. Neuropeptide Y may influence the synthesis and secretion of a variety of hormones by interacting with specific receptors in the hypothalamus and/or the pituitary. To fur...

journal_title：Peptides

authors： Gehlert DR,Gackenheimer SL,Millington WR,Manning AB,Chronwall BM

更新日期：1994-01-01 00:00:00

abstract：:Unilateral intracerebroventricular (ICV) injections of a high dose of CCK7 have been reported to elicit barrel rotations accompanied by contralateral postural asymmetry; there was no spontaneous locomotor activity other than barrel rolling. The aim of the present study was to investigate the effects of lower doses of ...

journal_title：Peptides

authors： Morency MA,Ross GM,Hesketh D,Mishra RK

更新日期：1987-11-01 00:00:00

abstract：:We investigated basal motility and the motor effects of motilin, erythromycin, and prostigmine on segments of rabbit gastrointestinal tract removed from extrinsic neural and vascular pathway and immersed in an oxygenated organ bath. Motility was recorded by means of four strain gauges sutured on the serosal surface of...

journal_title：Peptides

authors： Marzio L,Grossi L,Martelli L,Falcucci M,Lapenna D

更新日期：1994-01-01 00:00:00

abstract：:In an immunohistochemical study, a specific antiserum raised against [D-Ala2]deltorphin-I (DADTI), a highly selective ligand for delta opioid receptors, was used to demonstrate immunoreactive structures in the rat retina. [D-Ala2]Deltorphin-I immunoreactivity occurred in a subpopulation of the retinal amacrine cells s...

journal_title：Peptides

authors： Abe H,Tooyama I,Renda T,Erspamer V,Kimura H

更新日期：1994-01-01 00:00:00

abstract：:Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) and Tac1 gene-encoded tachykinins (substance P: SP, neurokinin A: NKA) are expressed in capsaicin-sensitive nerves, but their role in nociception, inflammation and vasoregulation is unclear. Therefore, we investigated the function of these neuropeptides and th...

journal_title：Peptides

authors： Botz B,Imreh A,Sándor K,Elekes K,Szolcsányi J,Reglődi D,Quinn JP,Stewart J,Zimmer A,Hashimoto H,Helyes Z

更新日期：2013-05-01 00:00:00

abstract：:Binding studies have shown that [125I]NKA is a selective ligand of tachykinin septide-sensitive binding sites from membranes of the rat submaxillary gland. Indeed, this ligand bound with high affinity to a single population of sites. In addition, competition studies indicated that natural tachykinins and tachykinin-re...

journal_title：Peptides

authors： Beaujouan JC,Saffroy M,Torrens Y,Sagan S,Glowinski J

更新日期：1999-11-01 00:00:00

abstract：:Due to recent emergence of fungal pathogens resistant to current antifungal therapies, several studies have been focused on screening of plant peptides to find novel compounds having antifungal activities. Here, a novel antifungal plant peptide, with molecular mass of 1230 Da was purified from fruits of Trapa natans b...

journal_title：Peptides

authors： Mandal SM,Migliolo L,Franco OL,Ghosh AK

更新日期：2011-08-01 00:00:00

abstract：:The definitive function of pancreatic polypeptide in mammalian physiology remains unknown. The identification of specific PP target tissues should be helpful to further investigations into the possible regulatory actions of this peptide. An in vivo radioreceptor assay was used in the rat to locate potential binding si...

journal_title：Peptides

authors： Shetzline MA,Zipf WB,Nishikawara MT

更新日期：1998-01-01 00:00:00

abstract：:Liver-expressed antimicrobial peptide 2 (LEAP-2) is a 40-residue cationic peptide originally purified from human blood ultrafiltrate. The native peptide contains two disulfide bonds and is unique regarding its primary structure. Its biological role is not known but a previous study showed that chemically synthesized L...

journal_title：Peptides

authors： Hocquellet A,Odaert B,Cabanne C,Noubhani A,Dieryck W,Joucla G,Le Senechal C,Milenkov M,Chaignepain S,Schmitter JM,Claverol S,Santarelli X,Dufourc EJ,Bonneu M,Garbay B,Costaglioli P

更新日期：2010-01-01 00:00:00

abstract：:The purpose of this study was to investigate in the aged animal the functional interaction between cholecystokinin (CCK) and amino acid neurotransmitter activity in the frontal cortex, a structure of importance in age-related disabilities. Guide cannula for repeated push-pull perfusion were implanted bilaterally in th...

journal_title：Peptides

authors： Peinado JM,Myers RD

更新日期：1988-05-01 00:00:00

abstract：:For clinical use, it is essential to develop potent endomorphin (EM) analogs with reduced antinociceptive tolerance. In the present study, the antinociceptive activities and tolerance development of four potent EM-1 analogs with C-terminal oligoarginine-conjugation was evaluated and compared in the radiant heat paw wi...

journal_title：Peptides

authors： Yuan BY,Liu WZ,Wang XF,Zhang YZ,Yang DJ,Wang CL

更新日期：2018-08-01 00:00:00

abstract：:Gastric inhibitory polypeptide (GIP) is a 42 amino acid hormone secreted from intestinal K-cells in response to nutrient ingestion. Despite a recognised physiological role for GIP as an insulin secretagogue to control postprandial blood glucose levels, growing evidence reveals important actions of GIP on adipocytes an...

journal_title：Peptides

authors： Irwin N,Gault VA,O'Harte FPM,Flatt PR

更新日期：2020-03-01 00:00:00

abstract：:Endocrine tumor cells in culture and in vitro cleavage assays have shown that PC1 and PC2 are capable of processing pro-CCK into smaller, intermediate and final, bioactive forms. Similar studies have shown that PC5 has the ability to process a number of propeptides. Here, we use GT1-7 (mouse hypothalamic) and SK-N-MC ...

journal_title：Peptides

authors： Cain BM,Vishnuvardhan D,Beinfeld MC

更新日期：2001-08-01 00:00:00

abstract：:The distributions of neuropeptides in paraffin-embedded tissue sections (PETS) of the eyestalk, brain, and thoracic ganglia of the shrimp Penaeus monodon were visualized by imaging mass spectrometry (IMS). Peptide signals were obtained from PETS without affecting morphological features. Twenty-nine neuropeptides compr...

journal_title：Peptides

authors： Chansela P,Goto-Inoue N,Zaima N,Sroyraya M,Sobhon P,Setou M

更新日期：2012-03-01 00:00:00

abstract：:Bombyxin-IV, a molecular species of bombyxin, which is a member of insulin-like heterodimeric peptides of the silkworm Bombyx mori with prothoracicotropic hormone activity, was synthesized. The A- and B-chains of bombyxin-IV containing four and two Cys residues, respectively, were first synthesized separately by solid...

journal_title：Peptides

authors： Maruyama K,Nagasawa H,Isogai A,Tamura S,Ishizaki H,Suzuki A

更新日期：1990-01-01 00:00:00

abstract：:Humanin (HN) and HN-derivatives are a family of peptides first reported in the last decade with potent in vitro and in vivo neuroprotective activity, which is mediated through a not completely elucidated mechanism. Recently, our group has evaluated the effect of various HN-derivatives on the 3-quinuclidinyl benzilate ...

journal_title：Peptides

authors： Evangelou A,Zikos C,Benaki D,Pelecanou M,Bouziotis P,Papadopoulos M,Borovickova L,Vesela I,Elbert T,Kunesová G,Pirmettis I,Paravatou-Petsotas M,Slaninová J,Livaniou E

更新日期：2009-12-01 00:00:00

abstract：:Many mammalian brain-gut peptides are known to be represented in invertebrate nervous systems; we have now examined the possibility that an invertebrate neuropeptide occurs in vertebrates. Antisera were raised in rabbits to the molluscan neuropeptide. Phe-Met-Arg-Phe-NH2 (FMRFamide). The antiserum used for radioimmuno...

journal_title：Peptides

authors： Dockray GJ,Vaillant C,Williams RG,Gayton RJ,Osborne NN

更新日期：1981-01-01 00:00:00

abstract：:The binding activity of several galanin fragments and analogs was measured on specific receptors present in rat brain and the rat pancreatic beta cell line Rin m 5F. In both tissues it was observed that: 1) galanin(3-29), galanin(10-29) and [Ile2]-galanin were ineffective for inhibiting [125I] galanin binding and 2) a...

journal_title：Peptides

authors： Lagny-Pourmir I,Lorinet AM,Yanaihara N,Laburthe M

更新日期：1989-07-01 00:00:00

abstract：:The effect and mode of action of pituitary adenylate cyclase activating polypeptide (PACAP) were studied in rat ileal strips. PACAP relaxed, concentration dependently, rat ileum and was 50 times more potent than the structurally related vasoactive intestinal polypeptide (VIP). The inhibitory action of PACAP was not mo...

journal_title：Peptides

authors： Katsoulis S,Clemens A,Schwörer H,Creutzfeldt W,Schmidt WE

更新日期：1993-05-01 00:00:00

abstract：:Prolactin releasing peptide (PrRP) was originally reported to act in the anterior lobe of the pituitary gland to stimulate prolactin (PRL) release; however, numerous other pharmacologic actions of PrRP have been described. In the central nervous system PrRP inhibits food intake, stimulates sympathetic tone, and activa...

journal_title：Peptides

authors： Samson WK,Taylor MM

更新日期：2006-05-01 00:00:00

abstract：:Obestatin is produced in the stomach from proghrelin by post-translational cleavage. The initial report claimed anorexigenic effects of obestatin in mice. Contrasting studies indicated no effect of obestatin on food intake (FI). We investigated influences of metabolic state (fed/fasted), environmental factors (dark/li...

journal_title：Peptides

authors： Kobelt P,Wisser AS,Stengel A,Goebel M,Bannert N,Gourcerol G,Inhoff T,Noetzel S,Wiedenmann B,Klapp BF,Taché Y,Mönnikes H

更新日期：2008-06-01 00:00:00

abstract：:This report reviews the hypothesis that peptides play a role in appetite modulation, stressing that the available evidence is predominantly pharmacological and thus caution needs to be taken in assigning physiological significance at this time. Two peptide systems have been postulated--a peripheral satiety system, typ...

journal_title：Peptides

authors： Morley JE,Levine AS,Gosnell BA,Mitchell JE,Krahn DD,Nizielski SE

更新日期：1985-01-01 00:00:00

abstract：:LL-37 is the single cathelicidin host defense peptide in humans with direct antimicrobial and immunomodulatory activities. Specific regulation of LL-37 synthesis has emerged as a novel non-antibiotic approach to disease control and prevention. Short-chain fatty acids, and butyrate in particular, were found recently to...

journal_title：Peptides

authors： Jiang W,Sunkara LT,Zeng X,Deng Z,Myers SM,Zhang G

更新日期：2013-12-01 00:00:00

abstract：:A new series of analogues of the potent opiate-like peptides dermorphins (mainly tetra- and pentapeptides) were synthesized in order to better evaluate the structure-activity relationships. Relative potencies were referred to dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), the prototype of this class of frog skin pe...

journal_title：Peptides

authors： Melchiorri P,Erspamer GF,Erspamer V,Guglietta A,De Castiglione R,Faoro F,Perseo G,Piani S,Santangelo F

更新日期：1982-09-01 00:00:00