Abstract：
:High levels of neuropeptide Y (NPY) are found in the hypothalamus, median eminence, pituitary portal blood, and the pituitary in a number of species. Neuropeptide Y may influence the synthesis and secretion of a variety of hormones by interacting with specific receptors in the hypothalamus and/or the pituitary. To further define the function of NPY in the pituitary, we have examined the distribution of NPY immunoreactivity and NPY receptors in sections of human pituitary using immunohistochemical and autoradiographic techniques. Neuropeptide Y-immunoreactive varicose axons were seen throughout the neural lobe. A moderate number of NPY-immunoreactive cells were found in the anterior lobe. A very high level of [125I]PYY binding was seen in the neural lobe with low levels in the anterior lobe. The binding in the neural lobe was inhibited by NPY(13-36) at a Ki of 5.3 nM and [Leu31-Pro34]NPY at a Ki of 390 nM, indicating the receptor was the Y2 subtype. Therefore, neuronally released NPY may modulate human neural lobe function through a Y2 receptor.
journal_name
Peptidesjournal_title
Peptidesauthors
Gehlert DR,Gackenheimer SL,Millington WR,Manning AB,Chronwall BMdoi
10.1016/0196-9781(94)90090-6subject
Has Abstractpub_date
1994-01-01 00:00:00pages
651-6issue
4eissn
0196-9781issn
1873-5169pii
0196-9781(94)90090-6journal_volume
15pub_type
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