Abstract:
:The aim was to study the effects of C-type natriuretic peptide (CNP) on mean arterial pressure (MAP) and the cardiovascular nitric oxide (NO) system in spontaneously hypertensive rats (SHR), and to investigate the signaling pathways involved in this interaction. SHR and WKY rats were infused with saline or CNP. MAP and nitrites and nitrates excretion (NO(x)) were determined. Catalytic NO synthase (NOS) activity and endothelial (eNOS), neuronal (nNOS) and inducible NOS (iNOS) were measured in the heart and aorta artery. NOS activity induced by CNP was determined in presence of: iNOS or nNOS inhibitors, NPR-A/B natriuretic peptide receptors blocker and Gi protein and calmodulin inhibitors. CNP diminished MAP and increased NO(x) in both groups. Cardiovascular NOS activity was higher in SHR than in WKY. CNP increased NOS activity, but this activation was lower in SHR. CNP had no effect on NOS isoforms expression. iNOS and nNOS inhibitors did not modify CNP-induced NOS activity. NPR-A/B blockade induced no changes in NOS stimulation via CNP in both tissues. Cardiovascular NOS response to CNP was reduced by Gi protein and calmodulin inhibitors in both groups. CNP interacts with NPR-C receptors, activating Ca-calmodulin eNOS via Gi protein. NOS response to CNP is impaired in the heart and aorta of SHR. Alterations in the interaction between CNP and NO would be involved in the maintenance of high blood pressure in this model of hypertension.
journal_name
Peptidesjournal_title
Peptidesauthors
Caniffi C,Elesgaray R,Gironacci M,Arranz C,Costa MAdoi
10.1016/j.peptides.2010.03.030subject
Has Abstractpub_date
2010-07-01 00:00:00pages
1309-18issue
7eissn
0196-9781issn
1873-5169pii
S0196-9781(10)00129-4journal_volume
31pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Experiments characterized the behavioral effects of bombesin (BN) administered systemically (1-8 micrograms/kg; IP) or centrally at the nucleus tractus solitarius (NTS) and the nucleus accumbens (NA) (0.0001-1.0 microgram/0.5 microliter). The role of dopaminergic system(s) in the mediation of BN-induced behavioral eff...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90249-5
更新日期:1988-01-01 00:00:00
abstract::Orexin (ORX) plays a critical role in reward-seeking behavior for natural rewards and drugs of abuse. The mesolimbic dopamine (DA) pathway that projects into the nucleus accumbens (NAc) from the ventral tegmental area is deeply involved in the neural mechanisms underlying reward, drug abuse and motivation. A recent st...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.10.023
更新日期:2011-02-01 00:00:00
abstract::Atrial dipeptidyl carboxyhydrolase readily converts one atrial natriuretic peptide, atriopeptin II (Ser103-Arg125 peptide), to another, atriopeptin I (Ser103-Ser123 peptide), by selective removal of the C-terminal dipeptide, Phe-Arg. The atrial peptides possess natriuretic, diuretic, smooth muscle relaxant, and cardio...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90077-6
更新日期:1989-01-01 00:00:00
abstract::Combined use of the intraaxonal retrograde transport of the fluorescent marker 'true blue' with substance P (SP) immunocytochemistry has been used to trace the nodose ganglion projections of SP-containing neurons of the aortic depressor nerve. It has been found that (1) SP immunoreactive (SP-I) cell bodies are clearly...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(80)90015-7
更新日期:1980-01-01 00:00:00
abstract::The release of peptides immunoreactive for a synthetic peptide (V-9-M) contained in the amino-terminal of pro-CCK was examined. The potassium-evoked release of V-9-M immunoreactive peptides from rat cerebral cortical slices in vitro was calcium dependent. Cholecystokinin-secreting rat medullary thyroid carcinoma cells...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90011-q
更新日期:1992-11-01 00:00:00
abstract::Angiotensin IV (Ang IV) is formed by aminopeptidase N from Ang III by removing the first N-terminal amino acid. Previously, we reported that Ang III has some cardioprotective effects against global ischemia in Langendorff heart. However, it is not clear whether Ang IV has cardioprotective effects. The aim of the prese...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2016.03.017
更新日期:2016-05-01 00:00:00
abstract::Acute treatment of rats with haloperidol results in a rapid and transient increase in striatal c-fos mRNA and Fos immunoreactivity. The induction of immediate early genes by haloperidol may be involved in the development of extrapyramidal side effects. L-Prolyl-L-leucyl-glycinamide (PLG, or MIF-1) has been observed to...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00194-1
更新日期:2000-02-01 00:00:00
abstract::Histidyl-proline diketopiperazine (cyclo(His-Pro), a metabolite of the neuropeptide thyrotropin releasing hormone, has been shown to possess intrinsic biological activities. The binding of this peptide to various tissue particulate preparations was investigated. While the peptide showed no apparent binding to particul...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90172-9
更新日期:1983-01-01 00:00:00
abstract::Age-related changes in NPY-driven angiogenesis were investigated using Matrigel and aortic sprouting assays in young (2 months.) and aged (18 months.) mice. In both assays, NPY-induced vessel growth decreased significantly with age. In parallel, aged mice showed reduced expression (RT-PCR) of Y2 receptors and the NPY ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00581-2
更新日期:2002-01-01 00:00:00
abstract::The neuropeptide calcitonin gene-related peptide (CGRP) may play a role in neurogenic inflammation, tissue remodeling of the uterine cervix, promoting vasodilation, parturition, and processing of sensory information in the spinal cord. CGRP-immunoreactive nerves of the cervix and spinal cord have been studied but cell...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00638-6
更新日期:2002-03-01 00:00:00
abstract::The secretin receptor is a member of a large family of G-protein-coupled receptors that recognize polypeptide hormone and/or neuropeptides. Charged, conserved residues might play a key role in their function, either by interacting with the ligand or by stabilizing the receptor structure. Of the four charged amino acid...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00122-9
更新日期:1999-01-01 00:00:00
abstract::The reperfusion injury salvage kinase (RISK) pathway is a fundamental signal transduction cascade in the cardioprotective mechanism of ischemic postconditioning. In the present study, we examined the cardioprotective role of oxytocin as a postconditioning agent via activation of the RISK pathway (PI3K/Akt and ERK1/2)....
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2016.10.001
更新日期:2016-12-01 00:00:00
abstract::Endothelin-1 may contribute to bronchial smooth muscle constriction and airway remodelling in asthma, where bronchial epithelial cells represent an important source of this peptide. We report here that asthmatic bronchial epithelial cells exposed to allergens in vitro induce the differentiation of airway fibroblasts i...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00194-0
更新日期:1997-01-01 00:00:00
abstract::The vasoactive peptide urotensin-II (U-II) is best known for its ability to regulate peripheral vascular and cardiac contractile function in vivo, and recent in vitro studies have suggested a role for the peptide in the control of vascular remodeling by inducing smooth muscle proliferation and fibroblast-mediated coll...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.05.028
更新日期:2005-12-01 00:00:00
abstract::Recently two hypothalamic releasing factors have been isolated, sequenced and synthesized: corticotropin-releasing factor (CRF) from sheep and rat hypothalami; and growth hormone-releasing factor (GH-RF) from tumors in human pancreas (hpGH-RF) and from rat hypothalami (rhGH-RF). Their biological potencies were tested ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90282-1
更新日期:1984-01-01 00:00:00
abstract::We have recently characterized bicarinalin as the most abundant peptide from the venom of the ant Tetramorium bicarinatum. This antimicrobial peptide is active against Staphylococcus and Enterobacteriaceae. To further investigate the antimicrobial properties of this cationic and cysteine-free peptide, we have studied ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2016.04.001
更新日期:2016-05-01 00:00:00
abstract::The synthesis is described of an analogue of the locust CRF-like diuretic peptide in which methionine in positions 1,3, and 13 is replaced by isosteric methyl-homoserine residues. This analogue has been tested for biological activity on Malpighian tubules in vitro, and feeding behavior in vivo. It is highly active in ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.09.010
更新日期:2003-10-01 00:00:00
abstract::Although the biological effects of adrenomedullin (AM) and PAMP have been reported extensively in animal studies and from in-vitro experiments, relatively little information is available on responses to the hormone administered to man. This review summarizes data from the few studies carried out in man. In healthy vol...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(01)00508-3
更新日期:2001-11-01 00:00:00
abstract::Generally, biomacromolecules, such as DNA, RNA, and proteins, cannot freely permeate into cells from outside the membrane. Protein transduction domains (PTDs) are peptides containing a large number of basic amino acids that can deliver macromolecules into living cells. Arginine-rich intracellular delivery (AID) peptid...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.06.006
更新日期:2009-09-01 00:00:00
abstract::We report herein the isolation and characterization of a novel glycine-rich antimicrobial peptide purified from the larvae of Drosophila virilis. A range of chromatographic methods was used for isolation and its antibacterial activity against Bacillus subtilis was employed to screen for the most active fractions. The ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.09.028
更新日期:2010-01-01 00:00:00
abstract::Because plasma levels of protein C (PC) or activated protein C (APC) are altered in certain diseases associated with vascular dysfunction, and APC has therapeutic potential in preventing microvascular coagulation in severe sepsis, potential vascular effects of PC and APC were compared to those of the vasoactive peptid...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00264-3
更新日期:2000-08-01 00:00:00
abstract::Three novel antimicrobial peptides designated ToAMP1, ToAMP2 and ToAMP3 were purified from Taraxacum officinale flowers. Their amino acid sequences were determined. The peptides are cationic and cysteine-rich and consist of 38, 44 and 42 amino acid residues for ToAMP1, ToAMP2 and ToAMP3, respectively. Importantly, acc...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.05.009
更新日期:2012-08-01 00:00:00
abstract::The cholecystokinin receptor-type 1 (CCK1R) is a G-protein coupled receptor localized in the animal gastrointestinal tract. Receptor activation by the natural peptide ligand CCK leads to a feeling of satiety. In this study, hydrolysates from soy and milk proteins were evaluated for their potential to activate the CCK1...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.11.019
更新日期:2012-03-01 00:00:00
abstract::Bradykinin-potentiating peptides (BPPs) are an important group of toxins present in Lachesis muta rhombeata venom. They act directly at renin-angiotensin-aldosterone system, through the inhibition of angiotensin-converting enzyme (ACE). This action may contribute to the hypotensive shock observed during the envenoming...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.01.015
更新日期:2018-04-01 00:00:00
abstract::The monoclonal antibody 2F5 recognizing the neutralizing epitope ELDKWA on the C-domain could neutralize 90% of the investigated HIV-1 isolates. Low levels of ELDKWA-epitope-specific antibodies were observed in HIV-1-infected individuals. To induce high levels of antibodies to ELDKW-epitope, C-domain peptide (P2) was ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00179-0
更新日期:2000-04-01 00:00:00
abstract::Neural input to distinct and separate populations of CRF-immunoreactive (ir) neurons in rat forebrain was investigated. The relationship of opiocortin and/or catecholamine fibers to different groups of CRF-containing neurons was elucidated using single and dual labeling immunocytochemical procedures. Antibodies to CRF...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90005-3
更新日期:1989-11-01 00:00:00
abstract::Although previous studies have implicated NPY in the etiology of experimental cancer anorexia, the results have been difficult to interpret. Studies have suggested that although NPY level and message were decreased in the dorsomedial hypothalamic area (DMA), they were elevated in the ventromedial hypothalamic area (VM...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.10.018
更新日期:2007-02-01 00:00:00
abstract::Melanocortins (MCs) are multifunctional peptide hormones that regulate a diversity of physiological functions. MCs have been implicated in sexual function in animals. We document here that a MC analog, Melanotan II (MTII), can enhance sexual function in human males (erectile activity) and females (increased levels of ...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2005.01.023
更新日期:2005-10-01 00:00:00
abstract::Sympathetic neurotransmitter neuropeptide Y (NPY) is associated with vascular remodelling, neointimal hyperplasia and atherosclerosis in experimental animal models and clinical studies. In order to study the role of sympathetic nerve-produced NPY in vascular diseases, transgenic mouse model overexpressing NPY in centr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.12.009
更新日期:2009-04-01 00:00:00
abstract::The presence of human melanin-concentrating hormone (MCH) was studied in the human brain by radioimmunoassay and immunocytochemistry. Immunoreactive MCH concentrations in the human brain ranged from 0.07 to 19.7 pmol/g wet weight. High performance liquid chromatography of the hypothalamus showed a large immunoreactive...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90158-d
更新日期:1993-05-01 00:00:00