Abstract:
:Endothelin-1 may contribute to bronchial smooth muscle constriction and airway remodelling in asthma, where bronchial epithelial cells represent an important source of this peptide. We report here that asthmatic bronchial epithelial cells exposed to allergens in vitro induce the differentiation of airway fibroblasts into myofibroblasts, and that they do so through a granulocyte/macrophage colony-stimulating factor-mediated upregulation of endothelin-1 production. By this mechanism bronchial epithelial cells may participate in the genesis of bronchial subepithelial fibrosis, a process which contributes to airway narrowing in asthma.
journal_name
Peptidesjournal_title
Peptidesauthors
Sun G,Stacey MA,Bellini A,Marini M,Mattoli Sdoi
10.1016/s0196-9781(97)00194-0subject
Has Abstractpub_date
1997-01-01 00:00:00pages
1449-51issue
9eissn
0196-9781issn
1873-5169pii
S0196-9781(97)00194-0journal_volume
18pub_type
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