Abstract：
:The vasoactive peptide urotensin-II (U-II) is best known for its ability to regulate peripheral vascular and cardiac contractile function in vivo, and recent in vitro studies have suggested a role for the peptide in the control of vascular remodeling by inducing smooth muscle proliferation and fibroblast-mediated collagen deposition. Therefore, U-II may play a role in the etiology of atherosclerosis. In the present study we sought to determine the expression of U-II in coronary arteries from patients with coronary atherosclerosis and from normal control subjects, using immunohistochemistry and in situ hybridization. In normal coronary arteries, there was little expression of U-II in all types of cells. In contrast, in patients with coronary atherosclerosis, endothelial expression of U-II was significantly increased in all diseased segments (P<0.05). Greater expression of U-II was noted in endothelial cells of lesions with subendothelial inflammation or fibrofatty lesion compared with that of endothelial cells underlined by dense fibrosis or minimal intimal thickening. Myointimal cells and foam cells also expressed U-II. In most diseased segments, medial smooth muscle cells exhibited moderate expression of U-II. These findings demonstrate upregulation of U-II in endothelial, myointimal and medial smooth muscle cells of atherosclerotic human coronary arteries, and suggest a possible role for U-II in the pathogenesis of coronary atherosclerosis.
journal_name
Peptidesjournal_title
Peptidesauthors
Hassan GS,Douglas SA,Ohlstein EH,Giaid Adoi
10.1016/j.peptides.2005.05.028subject
Has Abstractpub_date
2005-12-01 00:00:00pages
2464-72issue
12eissn
0196-9781issn
1873-5169pii
S0196-9781(05)00291-3journal_volume
26pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:Catestatin (CST) is an endogenous neuropeptide with multiple cardiovascular activities. The study is to investigate circulating CST levels in heart failure (HF) patients and to evaluate the role of CST as a biomarker for HF. Plasma CST concentrations were measured by enzyme-linked immunosorbent assay in 228 HF patient...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.05.003
更新日期：2013-08-01 00:00:00
abstract：:The bursa of Fabricius (BF) is acknowledged as central humoral immune organ unique to birds. Our purpose was to identify the potential function of a novel bursal-derived bioactive peptide. A bursal septpeptide (BSP-I), EPASGMM, first isolated from BF, reduced MCF and Hela tumor cells proliferation, and enhanced antitu...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.04.020
更新日期：2011-06-01 00:00:00
abstract：:Vestibular compensation is a process of CNS plasticity that is correlated to a return of resting activity in medial vestibular nucleus (MVN) neurons ipsilateral to a peripheral vestibular deafferentation. Systemic administration of melanocortin peptides accelerates the compensation process; the ACTH/MSH(4-9) analogue,...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(96)00021-6
更新日期：1996-01-01 00:00:00
abstract：:The binding of monoiodo 125I-Trp11-neurotensin to purified rat gastric fundus smooth muscle plasma membranes was characterized. Specific binding of ligand in subcellular fractions from rat fundus smooth muscle showed a distribution that paralleled that of several plasma membrane marker enzymes. 125I-Trp11-neurotensin ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90117-7
更新日期：1984-09-01 00:00:00
abstract：:The presence of alpha-hANP immunoreactive material in human heart and plasma was investigated with a specific and sensitive radioimmunoassay and immunohistochemical method. It was found that alpha-hANP immunoreactive staining of specific atrial granules was located around the nucleus of atrial cardiocytes. No immunore...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90057-4
更新日期：1986-01-01 00:00:00
abstract：:The opioid peptides, [3H]DAGO and [3H]DPDPE, bound to rat and guinea pig brain homogenates with a high, nanomolar affinity and to a high density of mu and delta receptors, respectively. [3H]DAGO binding to mu receptors was competitively inhibited by unlabelled opioids with the following rank order of potency: DAGO gre...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(89)90135-6
更新日期：1989-05-01 00:00:00
abstract：:In an attempt to establish the role of F8Famide in opioid activity modulation, we examined the effects of intracerebroventricular administration of the F8Famide analogs (1DME)Y8Fa and (3D)Y8Fa on intestinal transit in mice. (1DME)Y8Fa (0.88 to 22 nmol) inhibited intestinal transit as did F8Famide and morphine. An IP i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90108-s
更新日期：1993-07-01 00:00:00
abstract：:The present study investigated the effects of neuropeptide Y (NPY) on food intake and body temperature (Tbo) in free-feeding unrestrained rats following injection into the medial hypothalamic paraventricular nucleus (PVN) or the lateral perifornical hypothalamus (PFH). NPY (78-235 pmol) or saline was infused unilatera...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(95)00020-k
更新日期：1995-01-01 00:00:00
abstract：:Antisauvagine-30 (aSVG) is the only high-affinity antagonist for the corticotropin-releasing factor (CRF) type 2 (CRF(2)) receptor. A structure-activity relationship study was performed to pinpoint residues conferring aSVG's selectivity. The aSVG-analogues being N-terminally extended by one or two residues or containi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(02)00139-0
更新日期：2002-10-01 00:00:00
abstract：:Leukemia inhibitory factor (LIF) overexpression, induced by the intracerebroventricular (i.c.v.) injection of an recombinant adeno-associated viral vector encoding LIF (rAAV-LIF), resulted in a dose-dependent reduction in body weight (BW) gain, food intake (FI) and adiposity, evidenced by suppression of serum leptin a...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(02)00021-9
更新日期：2002-05-01 00:00:00
abstract：:TRH and PS-24 (a TRH peptidase resistant analogue) induce different effects on body temperature and motor activity in rats kept at 4 degrees C. PS-24 induced hypothermia, but TRH did not. PS-24 induced hypermotility, while TRH induced slight hypomotility. The thermal effect of TRH in hypophysectomized rats was similar...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(81)80024-1
更新日期：1981-07-01 00:00:00
abstract：:Female Zucker lean and obese rats were treated for 14 days with 3.5 micromol/kg oleoyl-estrone (OE) in liposomes (Merlin-2). After 0, 3, 6, 10, and 14 days of treatment, the rats were killed and hypothalamic nuclei (lateral preoptic, median preoptic, paraventricular, ventromedial and arcuate) were used for neuropeptid...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(98)00104-1
更新日期：1998-01-01 00:00:00
abstract：:A retrograde facilitation has been demonstrated in the one trial step-down inhibitory avoidance of melanin-concentrating hormone (MCH), when it was infused into rat hippocampal formation. Considering the high density of specific binding sites for the MCH peptide on the hippocampus and the participation of this structu...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(01)00591-5
更新日期：2002-01-01 00:00:00
abstract：:The presence of immunoreactive endothelin (IR-ET) in human saliva and rat parotid gland was investigated by radioimmunoassay. The IR-ET concentration (mean +/- SEM) in saliva taken from normal volunteers was 2.0 +/- 0.2 pmol/l (n = 15). The IR-ET concentration in rat parotid gland was 19.2 +/- 2.2 fmol/g wet weight (n...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(91)90151-e
更新日期：1991-07-01 00:00:00
abstract：:We screened nearly 1000 synthetic peptides and found that JAL-AK22 (KYEGHWYPEKPYKGSGFRCIHI), which is derived from the BoxA domain in the Tob1 protein, activates both unfolded and folded proMMP-7. Interestingly, the smaller derivative of JAL-AK22, termed JAL-TA9 (YKGSGFRMI) possessed auto-proteolytic activity and clea...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2019.03.005
更新日期：2019-06-01 00:00:00
abstract：:The distribution of somatostatin (SRIF) was examined in normal human forebrain, using thick vibratome cut sections. The unlabeled antibody enzyme method of immunocytochemistry revealed a widespread distribution of SRIF immunoreactive neurons and fibers throughout the septum, diencephalon and corpus striatum. Within th...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90109-9
更新日期：1986-09-01 00:00:00
abstract：:We investigated the plasma concentration of ghrelin peptide during pregnancy and lactation in rats. Plasma ghrelin levels on days 10 and 15 of pregnancy were significantly lower than those of the non-pregnant rats. Thereafter, the plasma ghrelin levels on day 20 of pregnancy sharply increased to levels comparable with...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.01.011
更新日期：2004-02-01 00:00:00
abstract：:High levels of neuropeptide Y (NPY) are found in the hypothalamus, median eminence, pituitary portal blood, and the pituitary in a number of species. Neuropeptide Y may influence the synthesis and secretion of a variety of hormones by interacting with specific receptors in the hypothalamus and/or the pituitary. To fur...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90090-6
更新日期：1994-01-01 00:00:00
abstract：:Irisin is a novel myokine and adipokine that has gained much attention recently due to its mechanisms of action. Irisin is secreted following proteolytic cleavage of its precursor fibronectin type III domain containing 5 (FNDC5). Following its release, irisin exerts its major action by increasing the expression of mit...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2018.03.018
更新日期：2018-06-01 00:00:00
abstract：:The ability of acute exercise to stimulate appetite and food intake depends on intensity, duration, and agouti-related protein (AGRP) levels. Fasting, as well as any negative energy balance, has been reported to increase AGRP expression in the arcuate nucleus (ARC) of the hypothalamus and other extra-hypothalamic tiss...
journal_title：Peptides
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.peptides.2007.02.004
更新日期：2007-05-01 00:00:00
abstract：:Recent refinements in methodology now permit the study of endogenous peptide hormones in their individual target cells. The investigations reported here deal with the question of whether endogenous ACTH can be detected in its target cells in the highly active adrenal gland of the normally lactating rat. This question ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(80)90062-5
更新日期：1980-10-01 00:00:00
abstract：:Selective GLP-1 secretagogues represent a novel potential therapy for type 2 diabetes mellitus. This study examined the GLP-1 secretory activity of the ethnomedicinal plant, Fagonia cretica, which is postulated to possess anti-diabetic activity. After extraction and fractionation extracts and purified compounds were t...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2016.01.015
更新日期：2016-04-01 00:00:00
abstract：:Ceratotoxin A (CtxA), a 36-residue alpha-helical cationic peptide isolated from the medfly Ceratitis capitata, exhibits strong antibacterial activity. To determine its mode of action against bacteria, we investigated the behavior of ceratotoxin A by incorporating it into planar lipid bilayers. Macroscopic and single c...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2003.09.015
更新日期：2003-11-01 00:00:00
abstract：:Humanin (HN) and HN-derivatives are a family of peptides first reported in the last decade with potent in vitro and in vivo neuroprotective activity, which is mediated through a not completely elucidated mechanism. Recently, our group has evaluated the effect of various HN-derivatives on the 3-quinuclidinyl benzilate ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.07.028
更新日期：2009-12-01 00:00:00
abstract：:Antimicrobial peptides (AMPs) and mucins are components of airway secretions and both contribute to the innate host defense system. At neutral pH, AMPs are positively charged, mucins negatively. It was the aim of the study to test whether these opposite charges result in interactions between AMPs and mucins. We measur...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.07.018
更新日期：2006-12-01 00:00:00
abstract：:Adrenocorticotropic Hormone (ACTH), Melanocyte-Stimulating Hormone (MSH), and related peptides have been shown to have several neurogenic effects: alteration of cerebral protein synthesis, RNA synthesis, protein phosphorylation, and neurotransmitter turnover. Furthermore, there appears to be an ACTH containing circuit...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(82)90101-2
更新日期：1982-05-01 00:00:00
abstract：:Two peptides, rHRnG and hproHRnG, which were encoded by the nucleotide sequences complementary to mRNA of rat hypothalamic gonadotropin-releasing hormone (GnRH) and human placental proGnRH(-3-13), respectively, were synthesized. A remarkable hydropathic anti-complementarity was observed in the N-terminal region betwee...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90144-0
更新日期：1986-11-01 00:00:00
abstract：:The interindividual variability of the hydrolysis of leucine enkephalin, and of the formation of its hydrolysis by-products has been studied in human plasma. In agreement with known data, the data obtained indicate that Leu-enkephalin is degraded by several enzymes, belonging to three classes: aminopeptidases, dipepti...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00129-0
更新日期：1997-01-01 00:00:00
abstract：:Hepcidin is a peptide hormone regulating iron metabolism, the dyshomeostasis of which has been implicated in dementia. Yet, data on hepcidin status in dementia are scanty, limited to Alzheimer's disease (AD) and inconsistent due to methodological problems with its determination using immunoassays and/or lack of homoge...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2019.170169
更新日期：2019-12-01 00:00:00
abstract：:It is well known that neuropeptide Y (NPY) and gamma-aminobutyric acid (GABA) exert antiepileptic effects in animal models. It has recently been shown that ghrelin neurons increase the activities of GABA and NPY in the brain. Therefore it can be said that ghrelin is an antiepileptic agent. In this study we aimed to in...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.04.003
更新日期：2007-06-01 00:00:00
