An in vitro investigation of the effects of the ACTH/MSH(4-9) analogue, Org 2766, on guinea pig medial vestibular nucleus neurons.

abstract：:Neurotensin(6-13) has been isolated and sequenced as the major form of neurotensin-like immunoreactivity (NTLI) in a human hepatic fibrolamellar carcinoma. Circulating NTLI in the patient, especially C-terminal, was very high. In additional studies, NT(6-13) was synthesized and compared with the purified tumor NTLI by...

journal_title：Peptides

authors： Read D,Shulkes A,Fernley R,Simpson R

更新日期：1991-07-01 00:00:00

abstract：:125I-Ang I binding to atypical sites on Mycoplasma hyorhinis-contaminated IEC-18 cell membranes increased with increasing pH and [NaCl] (ED50 at 500 mM; maximal 13-fold increase at 2 M NaCl). Alkali metal chlorides and sodium halides increased binding with rank orders of Na+ < K+ < Rb+ < Cs+ = Li+ and F- < Cl- < Br < ...

journal_title：Peptides

authors： Smith RD

更新日期：1999-01-01 00:00:00

abstract：:The effects of ICV administration of CGRP antiserum on active avoidance behavior were studied in rats. CGRP antiserum dilutions of 1:5, 1:10, 1:20, and 1:40 facilitated the extinction of active avoidance responses in a platform-jumping situation in the 3- and 6-h tests. In the 24-h test, only the CGRP antiserum diluti...

journal_title：Peptides

authors： Kovcs A,Telegdy G

更新日期：1994-01-01 00:00:00

abstract：:Cocaine- and amphetamine-regulated transcript peptide (CART) with its wide distribution in the brain of mammals has been the focus of considerable research in recent years. Last two decades have witnessed a steady rise in the information on the genes that encode this neuropeptide and regulation of its transcription an...

journal_title：Peptides

authors： Subhedar NK,Nakhate KT,Upadhya MA,Kokare DM

更新日期：2014-04-01 00:00:00

abstract：:Tachykinins are thought to be involved in extrinsic control of motility in the gastrointestinal tract. Using the isolated perfused porcine antrum with intact vagal innervation, we studied the effects of substance P, neurokinin A and capsaicin infusion, and electrical stimulation of the vagus nerves on antral motility ...

journal_title：Peptides

authors： Schmidt PT,Rasmussen TN,Holst JJ

更新日期：1997-01-01 00:00:00

abstract：:Two cDNAs, size 969 bp and 1146 bp respectively, encoding goldfish gamma-preprotachykinin (gamma-PPT) were identified. Both cDNAs contain the same 345 bp open reading frame. The deduced 114-amino acid gamma-PPT contains the sequence of substance P, carassin and neurokinin A. sequence analysis of the two cDNA 5'-untran...

journal_title：Peptides

authors： Lin XW,Peter RE

更新日期：1997-01-01 00:00:00

abstract：:Human beta-defensin 2 (hBD-2) is a 41-amino acid cationic peptide of the innate immune system that serves as antimicrobial molecule. We determined the bactericidal activity of synthetic hBD-2 against nosocomial strains belonging to eight different bacterial species and exhibiting various antimicrobial resistance pheno...

journal_title：Peptides

authors： Routsias JG,Karagounis P,Parvulesku G,Legakis NJ,Tsakris A

更新日期：2010-09-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) was recently found in myocardium at the mRNA and protein levels, but it is not known whether cardiomyocytes are able to produce CNP. The aim of this study was to determine the expression of CNP and its specific receptor NPR-B in cardiac cells, both in vitro and ex vivo. CNP, brain natr...

journal_title：Peptides

authors： Del Ry S,Cabiati M,Vozzi F,Battolla B,Caselli C,Forini F,Segnani C,Prescimone T,Giannessi D,Mattii L

更新日期：2011-08-01 00:00:00

abstract：:We have previously developed an in vitro model of rat brainstem explants. The latter release sizable amounts of calcitonin gene-related peptide (CGRP); basal release can be stimulated by such secretagogues as high KCl concentrations, veratridine or capsaicine. In this paradigm we investigated the activity of the analg...

journal_title：Peptides

authors： Greco MC,Lisi L,Currò D,Navarra P,Tringali G

更新日期：2014-06-01 00:00:00

abstract：:Cholecystokinin (CCK) and met-enkephalin (MEK) related peptides have been shown to alter feeding behavior subsequent to their injection into the peripheral circulation or directly into the brains of several species. To evaluate the potential role of endogenous brain pools of these peptides in feeding, groups of sheep ...

journal_title：Peptides

authors： Scallet AC,Della-Fera MA,Baile CA

更新日期：1985-09-01 00:00:00

abstract：:alpha-MSH immunoreactive peptides were fractionated and characterized in rat and human brain and rat pituitary by reversed phase high pressure liquid chromatographic techniques. alpha-MSH and deacetylated alpha-MSH were two major naturally existing peptides in both brain and pituitary gland. Subsequent experiments exa...

journal_title：Peptides

authors： O'Donohue TL,Handelmann GE,Chaconas T,Miller RL,Jacobowitz DM

更新日期：1981-10-01 00:00:00

abstract：:We have previously reported that hypoxia activates corticotrophin-releasing hormone (CRH) and the expression of its type-1 receptor (CRHR1) and induces disorders of the brain-endocrine-immune network. p53 is activated by hypoxia and involved in tumorigenesis and apoptosis. Whether CRHR1 regulates p53 transactivation t...

journal_title：Peptides

authors： Zhao Y,Wang MY,Hao K,Chen XQ,Du JZ

更新日期：2013-06-01 00:00:00

abstract：:To determine if different subtypes of mu-opioid receptors were involved in antinociception induced by endomorphin-1 and endomorphin-2, the effect of pretreatment with various mu-opioid receptor antagonists beta-funaltrexamine, naloxonazine and 3-methylnaltrexone on the inhibition of the paw-withdrawal induced by endom...

journal_title：Peptides

authors： Sakurada S,Hayashi T,Yuhki M,Fujimura T,Murayama K,Yonezawa A,Sakurada C,Takeshita M,Sato T,Zadina JE,Kastin AJ,Sakurada T

更新日期：2002-05-01 00:00:00

abstract：:Recent refinements in methodology now permit the study of endogenous peptide hormones in their individual target cells. The investigations reported here deal with the question of whether endogenous ACTH can be detected in its target cells in the highly active adrenal gland of the normally lactating rat. This question ...

journal_title：Peptides

authors： Nolin JM

更新日期：1980-10-01 00:00:00

abstract：:Kisspeptins are biologically active cleavage peptides of the KiSS-1 gene products with important roles in the suppression of tumor metastasis and in the reproduction. The aim of the present study is to clarify changes of the expression of kisspeptins and kisspeptin receptor in the kidney with and without chronic renal...

journal_title：Peptides

authors： Shoji I,Hirose T,Mori N,Hiraishi K,Kato I,Shibasaki A,Yamamoto H,Ohba K,Kaneko K,Morimoto R,Satoh F,Kohzuki M,Totsune K,Takahashi K

更新日期：2010-10-01 00:00:00

abstract：:Vasopressin is one of the key regulators of the body's water and solute balance. When this balance is pathologically disturbed, determination of serum vasopressin concentrations might be a helpful tool for guiding therapy. However, due to its instability and considerable association to platelets, reliable measurement ...

journal_title：Peptides

authors： Struck J,Morgenthaler NG,Bergmann A

更新日期：2005-12-01 00:00:00

abstract：:The effects of dipeptide cyclo-[His-Pro] (CHP), known to participate in the appetite behavior and food intake control, have been investigated using PC12 cells in culture as model system. We found that only in the presence of experimental conditions that cause cellular stress the cyclic dipeptide affect cellular prolif...

journal_title：Peptides

authors： Minelli A,Bellezza I,Grottelli S,Pinnen F,Brunetti L,Vacca M

更新日期：2006-01-01 00:00:00

abstract：:Neural membrane fractions, prepared from brain-subesophageal ganglion complexes of the adult lepidopteran Lymantria dispar, contain at least two peptidases capable of metabolizing locust adipokinetic hormone-I in vitro. The initial fragments, pGlu1-Leu2-Asn3 and Phe4-Thr5-Pro6-Asn7-Trp8-Gly9-Thr10, result from the act...

journal_title：Peptides

authors： Masler EP,Wagner RM,Kovaleva ES

更新日期：1996-01-01 00:00:00

abstract：:In the conscious dog migrating and nonmigrating colonic motor complexes (CMC) were recorded by means of chronically implanted strain gauge force transducers. Intravenous injection of a synthetic enkephalin analogue immediately induced a premature CMC at all three recording sites of the colon. Naloxone inhibited the en...

journal_title：Peptides

authors： Bickel M,Belz U

更新日期：1988-05-01 00:00:00

abstract：:In the Nucleus Ambiguus (NA) mu-receptors increased mean arterial pressure (MAP) and heart rate (HR) and kappa-receptors decreased MAP without altering HR. Mu-receptors in the Dorsal Motor Nucleus of the Vagus (DMV) increased MAP without changing HR whereas kappa-receptors in the DMV decreased HR without changing MAP....

journal_title：Peptides

authors： Hassen AH,Broudy EP

更新日期：1988-01-01 00:00:00

abstract：:We recently discovered that vascular responsiveness to adrenomedullin (AM), a vasoactive hormone, decreases after hemorrhage, which is markedly improved by the addition of its binding protein AMBP-1. One obstacle hampering the development of AM/AMBP-1 as resuscitation agents in trauma victims is the potential immunoge...

journal_title：Peptides

authors： Wu R,Dong W,Qiang X,Ji Y,Cui T,Yang J,Zhou M,Blau S,Marini CP,Ravikumar TS,Wang P

更新日期：2008-07-01 00:00:00

abstract：:Glucagon-related peptides such as glucagon, glucagon-like peptide-1, and oxyntomodulin suppress food intake in mammals and birds. Recently, novel glucagon-like peptide (GCGL) was identified from chicken brain, and a comparatively high mRNA expression level of GCGL was detected in the hypothalamus. A number of studies ...

journal_title：Peptides

authors： Honda K,Saneyasu T,Yamaguchi T,Shimatani T,Aoki K,Nakanishi K,Kamisoyama H

更新日期：2014-02-01 00:00:00

abstract：:This study aims to examine the antidepressant-like action of Ghrelin (Ghr), a hormone synthesized predominantly by gastrointestinal endocrine cells and released during periods of negative energy balance, in two behavioral models: tail suspension test (TST), a predictive model of antidepressant activity, and the olfact...

journal_title：Peptides

authors： Carlini VP,Machado DG,Buteler F,Ghersi M,Ponzio MF,Martini AC,Schiöth HB,de Cuneo MF,Rodrigues AL,de Barioglio SR

更新日期：2012-06-01 00:00:00

abstract：:In the adrenal gland all components of the renin-angiotensin system (RAS) are expressed in both the adrenal cortex and the adrenal medulla. In this review evidence shall be presented that a local secretory RAS exists in the adrenal cortex that stimulates aldosterone production and serves as an amplification system for...

journal_title：Peptides

authors： Peters J

更新日期：2012-04-01 00:00:00

abstract：:A pancreatic ductal carcinoma was established as a transplantable tumor line in an inbred strain of Syrian golden hamsters. Intracellular recordings of membrane potentials and input resistance were made from cultured cells obtained from the transplanted tumors using indwelling glass microelectrode. The mean value of t...

journal_title：Peptides

authors： Ueda N,Suzuki Y,Utsumi M,Obara T,Okamura K,Namiki M

更新日期：1984-03-01 00:00:00

abstract：:The use of protein A- and IgG-conjugated colloidal gold staining methods for the immuno-localisation of peptide hormones and neurotransmitters at light- and electron microscope level are described and discussed. Bright-field and dark-ground illumination modes have been used to visualise the gold-labelled antigenic sit...

journal_title：Peptides

authors： Varndell IM,Tapia FJ,Probert L,Buchan AM,Gu J,De Mey J,Bloom SR,Polak JM

更新日期：1982-05-01 00:00:00

abstract：:Injection of capsaicin into the hindpaw has been employed as a model of chemogenic nociception in mice. Intraplantar injection of nociceptin (30-240 pmol) produced a significant and dose-dependent antinociceptive activity in the capsaicin test. The nociceptin N-terminal fragments, (1-11) and (1-13), were also active w...

journal_title：Peptides

authors： Sakurada T,Komatsu T,Moriyama T,Sasaki M,Sanai K,Orito T,Sakurada C,Sakurada S

更新日期：2005-12-01 00:00:00

abstract：:Naltrexone, an opiate antagonist, was administered to young obese (ob/ob) and lean mice for five weeks. Animals had continuous access to food and received 10 mg/kg SC twice daily with equivalent volumes of saline given to controls. The effects on body weight, and pituitary and plasma levels of beta-endorphin-like mate...

journal_title：Peptides

authors： Recant L,Voyles NR,Luciano M,Pert CB

更新日期：1980-01-01 00:00:00

abstract：:D-Amino acid substitutions in the anti-inflammatory/antipyretic Ac-alpha-MSH(11-13)-NH2 tripeptide of Ac-alpha-MSH(1-13)-NH2 were made and the altered peptides were injected in mice treated with picryl chloride. Ear swelling, measured 3 and 6 h after application of the irritant, was reduced by IP injections of Ac-alph...

journal_title：Peptides

authors： Hiltz ME,Catania A,Lipton JM

更新日期：1991-07-01 00:00:00

abstract：:A putative genome duplication event within the Silurana lineage has given rise to the tetraploid Cameroon clawed frog Silurana epitropicalis (Fischberg, Colombelli, and Picard, 1982). Peptidomic analysis of norepinephrine-stimulated skin secretions of S. epitropicalis led to identification of 10 peptides with varying ...

journal_title：Peptides

authors： Conlon JM,Mechkarska M,Prajeep M,Sonnevend A,Coquet L,Leprince J,Jouenne T,Vaudry H,King JD

更新日期：2012-09-01 00:00:00