Abstract:
:Neurotensin(6-13) has been isolated and sequenced as the major form of neurotensin-like immunoreactivity (NTLI) in a human hepatic fibrolamellar carcinoma. Circulating NTLI in the patient, especially C-terminal, was very high. In additional studies, NT(6-13) was synthesized and compared with the purified tumor NTLI by HPLC analysis and by testing stability in plasma in vitro. These methods confirmed that the tumor NTLI was identical to NT(6-13). Since the metabolic clearance rate of synthetic NT(6-13) in sheep was 30-fold higher than NT(1-13), it suggests that the elevated plasma levels are the result of impaired clearance and/or markedly elevated production.
journal_name
Peptidesjournal_title
Peptidesauthors
Read D,Shulkes A,Fernley R,Simpson Rdoi
10.1016/0196-9781(91)90152-fsubject
Has Abstractpub_date
1991-07-01 00:00:00pages
887-92issue
4eissn
0196-9781issn
1873-5169pii
0196-9781(91)90152-Fjournal_volume
12pub_type
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