Abstract:
:Animal behavioral and neurochemical studies implicate dopaminergic systems in the neurological sequelae induced by estrogen. In the present study, we demonstrated for the first time that MIF-1, a neuropeptide unrelated to classical dopamine agonists, when given prior to, concurrently with, and after 17 beta-estradiol, antagonized significantly the estrogen-induced increase in the density of dopamine D-2 receptor both in the striatum and the mesolimbic area of male rat brain. The current findings have implications for the prophylactic and therapeutic potential for MIF-1 in extrapyramidal motor disorders caused by estrogen imbalance in humans.
journal_name
Peptidesjournal_title
Peptidesauthors
Rajakumar G,Chiu P,Chiu S,Johnson RL,Mishra RKdoi
10.1016/0196-9781(87)90127-6subject
Has Abstractpub_date
1987-11-01 00:00:00pages
997-1002issue
6eissn
0196-9781issn
1873-5169pii
0196-9781(87)90127-6journal_volume
8pub_type
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