Abstract：
:We investigated basal motility and the motor effects of motilin, erythromycin, and prostigmine on segments of rabbit gastrointestinal tract removed from extrinsic neural and vascular pathway and immersed in an oxygenated organ bath. Motility was recorded by means of four strain gauges sutured on the serosal surface of the segment. During basal recording, clusters of duodenal contractions that propagated distally, resembling phase III activity of migrating motor complex, were seen. Motilin (10(-6) M) and erythromycin (10(-6) M) induced a propagated cluster of contractions similar to the phase III recorded during the basal period. Prostigmine (10(-6) M) induced a simultaneous increase in gastric and small intestinal motility. Atropine (10(-5) M) prevented the motor effect of motilin, erythromycin, and prostigmine. Thus, MMCs do not appear to require central input for initiation and propagation. Motilin and erythromycin stimulate MMCs through an enteric cholinergic mechanism; therefore, the previously reported smooth muscle receptors for both substances were not apparent in the ex vivo preparation.
journal_name
Peptidesjournal_title
Peptidesauthors
Marzio L,Grossi L,Martelli L,Falcucci M,Lapenna Ddoi
10.1016/0196-9781(94)90072-8subject
Has Abstractpub_date
1994-01-01 00:00:00pages
1067-77issue
6eissn
0196-9781issn
1873-5169pii
0196-9781(94)90072-8journal_volume
15pub_type
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