Somatostatin as a mediator of the effect of neurotensin on pentagastrin-stimulated acid secretion in rats.

abstract：:In the last 10 years, saliva has been increasingly used as a diagnostic fluid and in predictions of disease progression. Leptin and ghrelin are synthesized in several tissues including the salivary glands. The action of ghrelin is antagonistic to that of leptin. This study was undertaken to measure and compare the sal...

journal_title：Peptides

authors： Aydin S,Halifeoglu I,Ozercan IH,Erman F,Kilic N,Aydin S,Ilhan N,Ilhan N,Ozkan Y,Akpolat N,Sert L,Caylak E

更新日期：2005-04-01 00:00:00

abstract：:Pretreatment with opioid antagonists enhances acquisition of Pavlovian fear conditioning. The present experiments attempted to characterize the type of opioid receptor responsible for this effect using a procedure that assessed the fear of rats to a chamber previously associated with electric shock (1 mA, 0.75 s). Fre...

journal_title：Peptides

authors： Fanselow MS,Kim JJ,Young SL,Calcagnetti DJ,DeCola JP,Helmstetter FJ,Landeira-Fernandez J

更新日期：1991-09-01 00:00:00

abstract：:The release of peptides immunoreactive for a synthetic peptide (V-9-M) contained in the amino-terminal of pro-CCK was examined. The potassium-evoked release of V-9-M immunoreactive peptides from rat cerebral cortical slices in vitro was calcium dependent. Cholecystokinin-secreting rat medullary thyroid carcinoma cells...

journal_title：Peptides

authors： Cao G,Beinfeld MC

更新日期：1992-11-01 00:00:00

abstract：:Studies were conducted in order to determine if selected neurons could be isolated from the brain using Sepharose-linked recognition complexes directed against or related to the biosynthetic/neurosecretory product of the desired neuronal population. Immunoreactive LRF neurons were precipitated when dispersed cells of ...

journal_title：Peptides

authors： Melrose PA,Knigge KM

更新日期：1985-03-01 00:00:00

abstract：:Opiate binding sites in five brain regions were labeled with the mu and delta markers, 3H-morphine and 3H-[D-Ala2,D-leu5]enkephalin, respectively. The highest densities of both 3H-morphine and 3H-DADLE labeled sites are found in striatum and frontal cortex. Hypothalamus and midbrain contain predominantly 3H-morphine l...

journal_title：Peptides

authors： Hewlett WA,Barchas JD

更新日期：1983-11-01 00:00:00

abstract：:A pancreatic ductal carcinoma was established as a transplantable tumor line in an inbred strain of Syrian golden hamsters. Intracellular recordings of membrane potentials and input resistance were made from cultured cells obtained from the transplanted tumors using indwelling glass microelectrode. The mean value of t...

journal_title：Peptides

authors： Ueda N,Suzuki Y,Utsumi M,Obara T,Okamura K,Namiki M

更新日期：1984-03-01 00:00:00

abstract：:Recent studies have provided evidence for the dense localization of atrial natriuretic factor (ANF) in the anteroventral third ventricle (AV3V) region of the rat brain. This area is currently thought to be involved in the regulation of blood pressure and fluid and electrolyte balance. To investigate whether ANF may pl...

journal_title：Peptides

authors： Sills MA,Nguyen KQ,Jacobowitz DM

更新日期：1985-11-01 00:00:00

abstract：:WH1fungin, a surfactin cyclopeptide from Bacillus amyloliquefaciens WH1, is firstly reported as a novel immunoadjuvant, which can markedly enhance the immune response when given in mixture with antigens. After intramuscular or subcutaneous immunization, WH1fungin can help to induce both of durable humoral and cellular...

journal_title：Peptides

authors： Gao Z,Wang S,Qi G,Pan H,Zhang L,Zhou X,Liu J,Zhao X,Wu J

更新日期：2012-11-01 00:00:00

abstract：:The localization of CCK8-, bombesin- and VIP-like immunoreactivities in the myenteric plexus of the guinea pig small intestine has been studied by radioimmunoassay of extracts of longitudinal muscle strips obtained with and without adherent myenteric plexus; concentrations were compared with those in other regions of ...

journal_title：Peptides

authors： Hutchison JB,Dimaline R,Dockray GJ

更新日期：1981-04-01 00:00:00

abstract：:Antibodies directed against amyloid beta protein (AssP) have been suggested to be effective in the treatment of Alzheimer's disease (AD). Here, we used in vivo and in vitro models to test some of the mechanisms by which antibodies may produce their effects. We found that the blood-to-brain uptake of murine AssP1-42 wa...

journal_title：Peptides

authors： Banks WA,Pagliari P,Nakaoke R,Morley JE

更新日期：2005-02-01 00:00:00

abstract：:Carnosine (beta-alanyl-L-histidine) is a dipeptide with antioxidant properties. Free radicals are involved in the pathogenesis of acute liver injury induced by thioacetamide (TAA). In this study, we investigated the effect of carnosine treatment on TAA-induced oxidative stress and hepatotoxicity. Rats were injected in...

journal_title：Peptides

authors： Mehmetçik G,Ozdemirler G,Koçak-Toker N,Cevikbaş U,Uysal M

更新日期：2008-03-01 00:00:00

abstract：:Guanylyl cyclases (GC) are widely distributed enzymes that signal via the production of the second messenger cGMP. The particulate guanylyl cyclases share a similar topology: an extracellular ligand binding domain and intracellular regulatory kinase-homology and cyclase catalytic domains. The natriuretic peptide recep...

journal_title：Peptides

authors： Schulz S

更新日期：2005-06-01 00:00:00

abstract：:By immunohistochemistry it was found that PHI- and VIP-like immunoreactivity (-IR) occurred in the same autonomic neurons in the upper respiratory tract, tongue and salivary glands with associated ganglia in rat, guinea-pig, cat, pig and man. VIP- and PHI-like immunoreactivity was also found in similar locations in th...

journal_title：Peptides

authors： Lundberg JM,Fahrenkrug J,Hökfelt T,Martling CR,Larsson O,Tatemoto K,Anggård A

更新日期：1984-05-01 00:00:00

abstract：:Neuronostatin is a 13-amino acid amidated peptide widely distributed in various organs including gastrointestinal tract. However, the effect of neuronostatin on gastrointestinal motility has not been well characterized. In the present work, effects of central administration of neuronostatin on gastric emptying and gas...

journal_title：Peptides

authors： Su SF,Yang AM,Yang SB,Wang NB,Lu SS,Wang HH,Chen Q

更新日期：2012-05-01 00:00:00

abstract：:Although several low amphipathic peptides have been known to exhibit antimicrobial activity, their mode of action has not been completely elucidated. In this study, using designed low amphipathic peptides that retain different alpha-helical content and hydrophobicity, we attempted to investigate the mechanism of these...

journal_title：Peptides

authors： Yamamoto N,Tamura A

更新日期：2010-05-01 00:00:00

abstract：:Are ACTH and insulin synthesized in tissues other than the pituitary and pancreas, respectively? ACTH and TSH are widely distributed in the rat brain but are restricted to the hypothalamic regions of the primate brain. It is concluded that these pituitary peptides are not synthesized in the brain in extrahypothalamic ...

journal_title：Peptides

authors： Yalow RS,Eng J

更新日期：1981-01-01 00:00:00

abstract：:The rat central and peripheral nervous system contains a widespread distribution of BPP-like immunoreactive neurons. Some of these neurons coexist with a catecholamine, probably mostly NE. This peptide appears to be releaseable by nerve stimulation. Catecholamine releasing agents such as reserpine do not appear to dep...

journal_title：Peptides

authors： Jacobowitz DM,Olschowka JA

更新日期：1982-05-01 00:00:00

abstract：:Amyloid deposition in Alzheimer fibrils forms neurotoxic senile plaques in a process that may be modulated by associated proteins. In this work we demonstrate the ability of laminin-1 and laminin-2 to inhibit fibril formation and toxicity on cultured rat hippocampal neurons. We confirm that the laminin-1-derived pepti...

journal_title：Peptides

authors： Morgan C,Bugueño MP,Garrido J,Inestrosa NC

更新日期：2002-07-01 00:00:00

abstract：:Previous studies have shown that the nervous system and other tissues of molluscs contain a number of peptides that potently excite molluscan hearts. Two such peptides, termed small cardioactive peptides A and B (SCPA and SCPB) are present in large quantities in the nervous system of Aplysia. These peptides are widely...

journal_title：Peptides

authors： Lloyd PE,Kupfermann I,Weiss KR

更新日期：1987-01-01 00:00:00

abstract：:The present status of our understanding of the feedback regulation of pancreatic secretion by peptide YY (PYY) released from the distal intestine is reviewed. Exocrine pancreatic secretion is primarily controlled by the cephalic (the vagus nerve), gastric (acid and pepsin secretion, and nutrients delivered into the du...

journal_title：Peptides

authors： Naruse S,Kitagawa M,Ishiguro H,Hayakawa T

更新日期：2002-02-01 00:00:00

abstract：:Several cardioactive peptides from the pulmonate snail Helix aspersa were tested for their effects on myocardial cAMP levels, but only the family of small cardioactive peptides (SCPs) were clearly effective. SCP increased cAMP in a dose dependent manner; the time course was phasic. The structure-activity relations of ...

journal_title：Peptides

authors： Reich G,Doble KE,Price DA,Greenberg MJ

更新日期：1997-01-01 00:00:00

abstract：:Angiotensin II (ANG II) receptors were present in the thymus of newborn rats (179 +/- 34 fmol/mg protein). In newborns, binding was predominantly localized in the trabecula, and was selectively displaced by the AT2 ligand CGP 42112A (83-85%) and to a lower extent by the AT1 antagonist losartan (15-17%), indicating a m...

journal_title：Peptides

authors： Corrêa FM,De Oliveira AM,Viswanathan M,Saavedra JM

更新日期：1994-01-01 00:00:00

abstract：:Native peptides can be regarded as surrogate markers for protease activity in biological samples. Analysis of peptides by peptidomics allows to monitor protease activity in vivo and to describe the influence of protease inhibition. To elucidate the potential of peptides as markers for in vivo protease inhibition we an...

journal_title：Peptides

authors： Tammen H,Hess R,Rose H,Wienen W,Jost M

更新日期：2008-12-01 00:00:00

abstract：:Kyotorphin is a unique biologically active neuropeptide (l-tyrosine-l-arginine), which is reported to have opioid-like analgesic actions through a release of Met-enkephalin from the brain slices. N-methyl-l-tyrosine-l-arginine (NMYR), an enzymatically stable mimetic of kyotorphin, successfully caused potent analgesic ...

journal_title：Peptides

authors： Neyama H,Hamada Y,Tsukahara R,Narita M,Tsukamoto K,Ueda H

更新日期：2018-09-01 00:00:00

abstract：:The decapeptide from the frog Hyla caerulea, caerulein (caerulein diethylammonium hydrate, ceruletide, CER) is chemically closely related to the C-terminal octapeptide of cholecystokinin (CCK-8). Like CCK-8, CER and some of its analogues produce many behavioural effects in mammals: inhibition of intake of food and wat...

journal_title：Peptides

authors： Zetler G

更新日期：1985-01-01 00:00:00

abstract：:Natriuretic peptide receptor C (NPR-C) is known to bind all natriuretic peptides with similar affinity. Given their biological role it is interesting that natriuretic peptides and their activated guanylate cyclases (NPR-A and NPR-B) are expressed in retinal amacrine cells. The purpose of this study is to examine the p...

journal_title：Peptides

authors： Abdelalim EM,Tooyama I

更新日期：2010-01-01 00:00:00

abstract：:ACTH-(1-24) inhibits the in vitro binding of the muscarinic antagonist [3H]QNB to membranes from rat brain. The magnitude of inhibition is dependent on the concentration of ACTH-(1-24). Kinetic analysis indicates a pure competitive inhibition which is suggestive of a reversible interaction of ACTH with muscarinic rece...

journal_title：Peptides

authors： Tonnaer JA,Van Vugt M,De Graaf JS

更新日期：1986-05-01 00:00:00

abstract：:The hypotensive effect of proadrenomedullin N-terminal 20 peptide (PAMP) was examined in conscious pregnant (8, 14, and 20 days of pregnancy) and nonpregnant rats. Intravenous administration of PAMP (3-60 nmol/kg) produced a dose-dependent depressor response in both pregnant and nonpregnant rats. However, the maximum ...

journal_title：Peptides

authors： Makino I,Makino Y,Kangawa K,Shibata K

更新日期：1999-12-01 00:00:00

abstract：:Parasitic worms come from two very different phyla-Platyhelminthes (flatworms) and Nematoda (roundworms). Although both phyla possess nervous systems with highly developed peptidergic components, there are key differences in the structure and action of native neuropeptides in the two groups. For example, the most abun...

journal_title：Peptides

authors： Day TA,Maule AG

更新日期：1999-01-01 00:00:00

abstract：:In the epileptic brain, hippocampal dentate granule cells become synaptically interconnected through the sprouting of mossy fibers. This new circuitry is expected to facilitate epileptiform discharge. Prolonged seizures induce the long-lasting neoexpression of neuropeptide Y (NPY) in mossy fibers. NPY is released spon...

journal_title：Peptides

authors： Nadler JV,Tu B,Timofeeva O,Jiao Y,Herzog H

更新日期：2007-02-01 00:00:00