Abstract:
:The biological activities of alpha-MSH des-acetyl MSH, gamma-MSH and LPH37-58 were compared using the Anolis rate method of bioassay. Dose-response data showed LPH37-58 to be equipotent with alpha-MSH, but des-acetyl MSH and gamma-MSH were found to be much less active. The effect of LPH37-58 was additive to that of alpha-MSH, indicating that LPH37-58 is a full agonist of alpha-MSH. The lower potency peptides des-acetyl MSH and gamma-MSH reduced the effect of alpha-MSH and are, therefore, partial agonists of alpha-MSH. The action of MSH peptides in vivo may be modulated by interaction with agonists.
journal_name
Peptidesjournal_title
Peptidesauthors
McCormack AM,Carter RJ,Thody AJ,Shuster Sdoi
10.1016/0196-9781(82)90134-6subject
Has Abstractpub_date
1982-01-01 00:00:00pages
13-6issue
1eissn
0196-9781issn
1873-5169pii
0196-9781(82)90134-6journal_volume
3pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Osmotic stress stimulates the release of the avian hypothalamic neuropeptide arginine vasotocin (AVT) into the peripheral circulation. We conducted the present study to investigate the effects of salt-loading on AVT secretion and AVT gene expression in specific hypothalamic nuclei in chickens. White Leghorn chickens w...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00190-3
更新日期:1997-01-01 00:00:00
abstract::In this study we investigated the role that dopaminergic pathways play in the miotic effect exerted by neurotensin after intracameral administration. Neurotensin was injected into the anterior chamber (AC) at a dose of 30 micrograms to 4 groups of albino rabbits which had previously undergone the following treatment: ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90165-2
更新日期:1990-11-01 00:00:00
abstract::Of twelve dipeptides tested, only the Trp containing peptides Val-Trp and its reverse peptide Trp-Val showed a xanthine oxidase (XO) inhibitory activity. Studies with Val and Trp revealed that XO inhibition was mainly attributed to the Trp residue. No significant difference (P ≥ 0.05) was found for the XO inhibitory p...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.07.030
更新日期:2012-10-01 00:00:00
abstract::Five native pyrokinin-like peptides (Neb-PK-1, Neb-PK-2, Neb-PVK-1, [L9]Neb-PVK-2, [I9]Neb-PVK-2) identified in the neuropeptidome of the flesh fly Neobellieria bullata were compared for their quantitative and/or qualitative effects on puparium formation (pupariation). In a standard pupariation bioassay, both Neb-PVK-...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.08.023
更新日期:2006-03-01 00:00:00
abstract::The effect of EGF on the incorporation of [3H]TdR into DNA (DNA synthesis) was determined in the esophagus, liver, pancreas, and kidney in mice standardized to 12 hours (hr) of light alternating with 12 hr of darkness. A question asked was whether intraperitoneally administered EGF could alter the circadian patterns o...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90110-0
更新日期:1987-03-01 00:00:00
abstract::Mussels have diverse groups of cysteine rich, cationic antimicrobial peptides (AMPs) (defensins, mytilins, myticins, and mytimycin) that constitute an important component of their innate immune defence. Despite the identification and characterization of these AMPs in mussels, the underlying genetic mechanisms that mai...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.03.007
更新日期:2008-07-01 00:00:00
abstract::Trefoil factor family (TFF) 1, 2, and 3 is a mucin-associated protein involved in the maintenance of mucosal barrier and restitution of lining epithelial cells. In this study, the expression of TFF1, 2, and 3 and MUC mucins were examined immunohistochemically in hepatolithiasis and control livers. The expression of TF...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.12.023
更新日期:2004-05-01 00:00:00
abstract::The amino acid sequence of the vasoactive intestinal polypeptide (VIP) is well conserved between species. Thus, all mammalian VIPs isolated so far, except that of the guinea pig, have the same amino acid sequence. This study describes the isolation and primary structure of sheep brain VIP. The purification was followe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90184-7
更新日期:1990-07-01 00:00:00
abstract::Multiple-time regression analysis has been used to study the influx of radiolabeled peptides and polypeptides across the blood-brain barrier (BBB). This study used both tritiated and iodinated leptin to clarify several issues associated with these measurements. Recombinant murine leptin was radiolabeled with 3H by der...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00569-1
更新日期:2001-12-01 00:00:00
abstract::Melanin-concentrating hormone (MCH) is a potent orexigenic and sleep-promoting neuropeptide in mammals produced predominately by hypothalamic neurons which project to a wide variety of brain areas. Several MCH producing neurons contain MCH as the only neuropeptide, while others comprise cocaine- and amphetamine regula...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.11.002
更新日期:2018-01-01 00:00:00
abstract::A non-specific lipid transfer peptide (nsLTP) with antimicrobial activity was isolated from the mung bean (Phaseolus mungo) seeds. The procedure entailed aqueous extraction, ion exchange chromatography on CM-Sephadex and high performance liquid chromatography (HPLC) on POROS-HS-20. The peptide exhibited a molecular ma...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.06.004
更新日期:2004-08-01 00:00:00
abstract::Previous physiological studies have suggested central roles of brain natriuretic peptide (BNP). However, little information is available about the localization of BNP in the brain. In this study, we determined cDNA sequence encoding the entire coding region of prepro-BNP of Japanese and cynomologus monkeys, and then e...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.01.001
更新日期:2006-07-01 00:00:00
abstract::The binding activity of several galanin fragments and analogs was measured on specific receptors present in rat brain and the rat pancreatic beta cell line Rin m 5F. In both tissues it was observed that: 1) galanin(3-29), galanin(10-29) and [Ile2]-galanin were ineffective for inhibiting [125I] galanin binding and 2) a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90109-5
更新日期:1989-07-01 00:00:00
abstract::Honeybee stings are a severe public health problem. Bee venom contains a series of active components, including enzymes, peptides, and biogenic amines. The local reactions observed after envenoming include a typical inflammatory response and pain. Honeybee venom contains some well-known polycationic peptides, such as ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2014.07.004
更新日期:2014-09-01 00:00:00
abstract::We investigated the ability of sulfated cholecystokinin (26-33) (CCK-8) and cholecystokinin (30-33) (CCK-4) to induce taste aversion or avoidance conditioning (TAC) in a one-bottle testing paradigm after either intravenous (i.v.), intracerebroventricular (i.c.v.), or intraperitoneal (i.p.) administration. Significant ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00025-4
更新日期:1998-01-01 00:00:00
abstract::VIP stimulates adenylate cyclase activity of male and female rat anterior pituitaries and human prolactinomas, while dopamine inhibits the enzyme activity of female rat pituitaries and prolactinomas. A dopamine inhibited cyclase can be detected also in male rats provided the enzyme activity is increased by VIP. The an...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90172-4
更新日期:1984-11-01 00:00:00
abstract::The roles of thyrotropin releasing hormone (TRH) and oxytocin as central regulators of gastric motility were investigated. Picomolar (4 picomoles) quantities of TRH injected into the dorsal motor nucleus of the vagus (DMN) elicited a significant increase in gastric motility while the same quantity of oxytocin elicited...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90017-9
更新日期:1987-05-01 00:00:00
abstract::Thyroglobulin (Tg) is cleaved into several peptides during thyroid hormone synthesis, an oxidative process. P40, an iodinated C-terminal peptide from human Tg, has a molecular weight of about 40 kDa and contains two hormonogenic sites. P40 is the smallest peptide that is still recognized by monoclonal antibodies from ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.03.020
更新日期:2004-06-01 00:00:00
abstract::Angiotensin II (Ang II) uptake and transport across monolayers of bovine brain microvessel endothelial cells (BMECs) was demonstrated. Ang II transport was linear up to 2 h, saturable with a K(m) of 1.7 nM, and tended to be polarized with the apical-to-basolateral transport being greater. [3H]Ang II transport was foun...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00054-0
更新日期:1998-01-01 00:00:00
abstract::High levels of neuropeptide Y (NPY) are found in the hypothalamus, median eminence, pituitary portal blood, and the pituitary in a number of species. Neuropeptide Y may influence the synthesis and secretion of a variety of hormones by interacting with specific receptors in the hypothalamus and/or the pituitary. To fur...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90090-6
更新日期:1994-01-01 00:00:00
abstract::Suppression subtractive hybridization comparing brains from diapausing and nondiapausing pupae of the flesh fly, Sarcophaga crassipalpis, suggested that the gene encoding neuropeptide-like precursor 4 (Nplp4) was uniquely expressed during diapause. We have sequenced the full-length cDNA encoding Nplp4 and used Norther...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.10.008
更新日期:2009-03-01 00:00:00
abstract::Ghrelin is broadly expressed in myocardial tissues, where it exerts different functions. It also has been found to have a wide variety of biological functions on cell differentiation and tissue development. The aim of this study was to investigate the effect of ghrelin on human embryonic stem cell (hESC) differentiati...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.02.006
更新日期:2012-04-01 00:00:00
abstract::Neural input to distinct and separate populations of CRF-immunoreactive (ir) neurons in rat forebrain was investigated. The relationship of opiocortin and/or catecholamine fibers to different groups of CRF-containing neurons was elucidated using single and dual labeling immunocytochemical procedures. Antibodies to CRF...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90005-3
更新日期:1989-11-01 00:00:00
abstract::Recently two hypothalamic releasing factors have been isolated, sequenced and synthesized: corticotropin-releasing factor (CRF) from sheep and rat hypothalami; and growth hormone-releasing factor (GH-RF) from tumors in human pancreas (hpGH-RF) and from rat hypothalami (rhGH-RF). Their biological potencies were tested ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90282-1
更新日期:1984-01-01 00:00:00
abstract::CART (cocaine- and amphetamine-regulated transcript) peptides are neuropeptides abundant in the central nervous system and periphery found to be involved in the regulation of food intake behavior and other physiological processes. Recently, we reported specific binding of (125)I-CART(61-102) to the rat adrenal pheochr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.07.022
更新日期:2007-10-01 00:00:00
abstract::The multifunctional arthropod 'insect kinins' share the evolutionarily conserved C-terminal pentapeptide motif Phe-X1-X2-Trp-Gly-NH2, where X1=His, Asn, Ser, or Tyr and X2=Ser, Pro, or Ala. Eight different analogs of the insect kinin C-terminal pentapeptide active core in which the critical residues Phe 1, Pro3 and Tr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.07.034
更新日期:2008-02-01 00:00:00
abstract::The prothoracicotropic hormones (PTTH) are cerebral peptides that control insect postembryonic development by stimulating the prothoracic glands to synthesize ecdysteroids. Using immunoaffinity chromatography and SDS-PAGE, a 25.5 kDa big PTTH has been purified from Manduca sexta. Based upon SDS-PAGE and Western blot a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90142-4
更新日期:1993-05-01 00:00:00
abstract::The binding and internalization of a cytotoxic analogue of luteinizing hormone-releasing hormone (LH-RH), T-98 (agonist [D-Lys6]LH-RH linked to glutaryl-2-(hydroxymethyl)anthraquinone), by rat anterior pituitary cells was investigated. Analogue T-98 was bound to pituitary membrane binding sites for LH-RH with a high a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90024-8
更新日期:1994-01-01 00:00:00
abstract::During a systemic search for peptides that possess the C-terminal amide structure, a novel heptapeptide with isoleucine amide was isolated from bovine serum by sequential steps of reversed phase HPLC. Microsequence and amino acid analyses revealed the structure: Asp-Thr-His-Lys-Ser-Glu-Ile-NH2. Since this peptide has ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90031-j
更新日期:1991-03-01 00:00:00
abstract::Skh-AMP1 (GRTSKQELCTWERGSVRQADKTIAG) is an antifungal peptide isolated from Satureja khuzistanica which has been shown to have strong antifungal activity against Aspergillus and Candida species, but no obvious hemolytic effects or cell cytotoxicity in vitro. In the present study, Skh-AMP1 was synthesized, and its mode...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2019.170195
更新日期:2020-01-01 00:00:00